DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and plekha1a

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_998601.1	Gene:	plekha1a / 406745	ZFINID:	ZDB-GENE-040426-2780	Length:	401	Species:	Danio rerio

Alignment Length:	401	Identity:	78/401 - (19%)
Similarity:	120/401 - (29%)	Gaps:	134/401 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2185 TETDATARFMD---------KHLSDLEQ---ENLTDGT--------CDIV-AYMESLREKAFDPQ 2228
            |:..:...:||         ||:..|..   ..::|.|        |.:: |.|.....:|.|.|
Zfish    34 TQQGSLLWYMDNPQNLPVGAKHVGFLSLTYISKVSDATKQRPKAEYCFVINAGMRKYFLQANDQQ 98

  Fly  2229 DLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEE 2293
            ||.|                  .|........:.:...|.| ..|:|...|:     :|::.:..
Zfish    99 DLVE------------------WVNALNNATKITVPKSSDP-VHSESQKLTS-----NGNKKQVP 139

  Fly  2294 ATTSSLASHIVVIDKKV----------DKIFKAKSPERPASTKVKGGRRQIYISPDRCKSQGS-- 2346
            ..|..:|...||...:.          :|:...|.|..|.....:.|:.|..|....|..||:
Zfish   140 YKTEIIAGVAVVTQTQQVGEVGHSVAGEKLGLRKPPNHPPYLHTRAGQDQAVIKAGYCVKQGALM 204

  Fly  2347 ------------------------SPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGR-- 2385
                                    .|:|||.:|...   ..|..:.|....|||..:.::..|
Zfish   205 KNWKRRYFVLEQNSMSYFKSDLEKEPLRIILLKEVH---KVQECKHSEIMMRDNLFEVVTTSRTF 266

  Fly  2386 ------------------------RTPSPRRSSE----GGGILKHTTGPDPGILKPPSSPAKSKS 2422
                                    |.|....:||    |....:..||   .::...:|||.|..
Zfish   267 FVQADSPEEMHGWIKAISGAIVAQRGPGRSAASEHIVGGSCFYRQHTG---SVIPWTASPAVSGH 328

  Fly  2423 PDRSCLKKGGPSHVCSVETLSPRVS---------PRGSMDHLSPDRGMTS-SSCLRHSPRSSFDS 2477
            |:|....:.|.......|..:|..|         |...:.|.||.|..:| ..|....|:...|
Zfish   329 PERHGPARPGMGQRALHEPAAPAPSTRPPVIARDPPVQVTHESPWRRRSSMGMCDAPLPQLDLD- 392

  Fly  2478 HGESDHNLDVP 2488
                  |.|:|
Zfish   393 ------NADLP 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
plekha1a	NP_998601.1	PH1_TAPP1_2	1..118	CDD:270089	18/101 (18%)
		PH	10..112	CDD:278594	18/95 (19%)
		PH2_TAPP1_2	184..297	CDD:270090	19/115 (17%)
		PH	191..287	CDD:278594	15/98 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910