DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and akt2l

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_021334818.1	Gene:	akt2l / 403146	ZFINID:	ZDB-GENE-040121-5	Length:	625	Species:	Danio rerio

Alignment Length:	710	Identity:	125/710 - (17%)
Similarity:	216/710 - (30%)	Gaps:	212/710 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   868 LSVKK--WLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAP-KHLIIVDGAIM 929
            |||.|  |||::...|:..|.|    |::.....:.:.|. :..|......|| .:..:.:..:|
Zfish     4 LSVVKEGWLLKRGEYIKTWRPR----YFILKSDGSFIGYK-EKPELTDQSCAPLNNFSVEECQLM 63

  Fly   930 QPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARH-------------- 980
            :.....|....|.||.........|......|.:.|:.:|........||.
Zfish    64 KTERPRPNTFMIRCLQWTTVIERTFHVDSSDERDEWMRAIQMVANGLQARDVDEPMEIKYSSPSD 128

  Fly   981 ----------------------------RGKTGTLHLLQE---------EIFRLEKAIESDHKLK 1008
                                        :|..|.:.|::|         :|.|.|..|..| ::.
Zfish   129 ALEDMEMCLSKSSSRVTMNDFDYLKLLGKGTFGKVILVREKASGMYYAMKILRKEVIIAKD-EVA 192

  Fly  1009 HMAELQQSVVTD----QETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTH 1069
            |       .||:    |.|||...|.:....:..:||        |::.     |..|...|..|
Zfish   193 H-------TVTESRVLQNTRHPFLTTLKYAFQTHDRL--------CFVM-----EYANGGELFFH 237

  Fly  1070 VSRP---TKNTLNKLGVFTVSSF---HA-FICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSR 1127
            :||.   :::.....|...||:.   |: .:..|...|.|.:|...|..|.....|.:  .|.:.
Zfish   238 LSRERVFSEDRARFYGAEIVSALDYPHSQNVVYRHLKLENLMLDNDGHIKITDFGLCK--EGITD 300

  Fly  1128 RSMQMNSRDEPEKTFKVAMPDNAYST--------VYLRDAMSVEEFLASACARRNLNPMEHFVRV 1184
            .:........||......:.||.|..        |.:.:.|         |.|......:| .|:
Zfish   301 EATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM---------CGRLPFYSQDH-ERL 355

  Fly  1185 KKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAER 1249
            .::..||:..:         ...|..|      .:.|....|::...:::.|...:|
Zfish   356 FEQIVMEEIRF---------PRSLSTH------ARALLTGLLRKEPKQRLGGGPDDA-------- 397

  Fly  1250 QDELCCYVSRVEDKSVAMHNGI--IKGDEIM------VINGAIVSDLDMMYLESVLQEEQSLSMM 1306
                         :.|.||...  ::.|:::      .....:.|:.|..|.:.        ...
Zfish   398 -------------RDVMMHKFFSGVQWDDVLQKKLLPPFKPQVTSETDTRYFDD--------EFT 441

  Fly  1307 MRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSE-----------------EMITGLIVP 1354
            .:|....|||.:....|              .:|.|:.:                 ||:.|.:
Zfish   442 AQSITVTPPDKLSCQDV--------------EEPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL-- 490

  Fly  1355 APGWNGTSKDLYS---PEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFE-- 1414
             |.:|...:.|:.   .|....|.|...|..::.:.|.:......:.||...||...|.|.|.
Zfish   491 -PFYNQDHEKLFELILMEDIKFPRTLSADAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFTGI 554

  Fly  1415 ------IENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTER 1468
                  .:.|:...:.:....:.|.......:...:|    :|..||..:..|:.:|.||
Zfish   555 DWQDVYDKKLIPPFKPQVSSETDTRYFDEEFTAQTIT----ITPPEKFDEDGMDCMDNER 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	27/161 (17%)
		PH	873..974	CDD:278594	20/101 (20%)
		TIAM1_RBD	1141..1219	CDD:176413	13/85 (15%)
		PDZ_signaling	1221..1308	CDD:238492	11/94 (12%)
		RhoGEF	1456..1647	CDD:238091	4/13 (31%)
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
akt2l	XP_021334818.1	PH_PKB	4..111	CDD:269947	24/111 (22%)
		PKc_like	153..462	CDD:328722	69/399 (17%)
		PKc_like	<423..551	CDD:328722	27/152 (18%)
		S_TK_X	553..621	CDD:214529	10/62 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910