DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF37

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_011535944.1 Gene:ARHGEF37 / 389337 HGNCID:34430 Length:686 Species:Homo sapiens


Alignment Length:888 Identity:173/888 - (19%)
Similarity:287/888 - (32%) Gaps:326/888 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1380 DPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTAL 1444
            :||.||..              |..:|:||:.|         .::|.|.|.              
Human     8 EPADMAKH--------------GADEPSSRSGS---------PDREGRASE-------------- 35

  Fly  1445 TPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTF 1509
              .|.|...   |..|.||:|||.:|: |:..|....:....::  |...:::.||.||.:|:..
Human    36 --DRSLLHQ---RLAVRELIDTEVSYL-HMLQLCASDIRSRLQQ--LPQGDLDVLFSNIDDIIKV 92

  Fly  1510 QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF-KLYSSFCASHSKAQKVL-- 1571
            ..:||.:|:|:...|.:            .:..:|:.||.:.... ::|..:|||:.:|..::  
Human    93 NSRFLHDLQETASKEEE------------QVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDT 145

  Fly  1572 ---HPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLC 1633
               .|....| :|..:.|..| |..||.|...|:.|:|||.:||||||::...|...|..:..|.
Human   146 YRKEPELQRH-IQGIVEAVVP-QAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQ 208

  Fly  1634 EALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLG 1698
            .|:..::.|..:||| .::.:|..:                         .|..||.|.:.:.|.
Human   209 RAVSALQDVNTNINE-YKMRKEVAS-------------------------KYTKVEQLTLRERLA 247

  Fly  1699 KIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQV-LIPVTEVQVRAS 1762
            :|    ..|.:                          ||..|...::::.:. |||.||    ..
Human   248 RI----NTHTL--------------------------SKKTTRLSQLLKQEAGLIPRTE----DK 278

  Fly  1763 SAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQII--RESVRNMSIP---- 1821
            ...|::..|.|.           |..|..|.|:.|    |:|..::..:  |....|:.||    
Human   279 EFDDLEERFQWV-----------SLCVTELKNNVA----AYLDNLQAFLYFRPHEYNLDIPEGPA 328

  Fly  1822 -----------MKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKS 1875
                       ::.|......:.|...|.:.|:     ::.|..|:..|            ||: 
Human   329 VQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSL-----AKALLGPQNLI------------KKR- 375

  Fly  1876 GSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHY---ASGHTHGQQMQPAGFRGRSKTVGDVTEIT 1937
                       .|.|...:..::....||.|.|   |:.||: |.:       .|..|.::    
Human   376 -----------LDKLLDFERVEEKLLEVGSVTYQEEAARHTY-QAL-------NSLLVAEL---- 417

  Fly  1938 CSSPEPHQQQQQ------------QQQQQQQLMQQGHAHAHPHPHPHPREP-------------- 1976
               |:.:|...|            |:...:|::|:........||.|..||              
Human   418 ---PQFNQLVMQWLGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTS 479

  Fly  1977 -------------PPPPIRQPHLHHHSSDIE----RIDPGTKSEGEED-SQQGTIRPKATLGRTP 2023
                         .|||..||.|......::    |..||...:...: |..||:          
Human   480 NQLRSFQETFEKVQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTL---------- 534

  Fly  2024 NHLTLSTTSTLSV----GSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQV 2084
             .|||.....:::    .:.|:..|.:..:.....|.|.....|....|...||..::       
Human   535 -DLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQA------- 591

  Fly  2085 AASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPR-QSPRQSPRQSPKQDI--EVIEIF- 2145
                                             .|:..|| .:|..||...|....  :||..: 
Human   592 ---------------------------------GLNKDPRCLTPEPSPALVPSIPTMNQVIAAYP 623

  Fly  2146 ----ESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNP 2184
                .|....|.|.|.|.::              :.:|:..||
Human   624 FVARSSHEVSLQAGQPVTIL--------------EAQDKKGNP 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 54/196 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 30/190 (16%)
PH 1693..1812 CDD:278594 21/121 (17%)
ARHGEF37XP_011535944.1 RhoGEF 45..223 CDD:279015 54/194 (28%)
BAR_DNMBP 275..463 CDD:153273 46/250 (18%)
SH3_ARHGEF37_C1 521..574 CDD:212733 10/63 (16%)
SH3_ARHGEF37_C2 617..673 CDD:212874 10/50 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3224
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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