DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and RhoGEF3

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster


Alignment Length:2399 Identity:457/2399 - (19%)
Similarity:742/2399 - (30%) Gaps:919/2399 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 LVQPGTRIGQASECFV--YWKDPMTNDTWGLNFTSP--IDAK-----QFREC----CS---PSFK 145
            |..||.|...|.:.|:  :.:...:|    ::.|.|  :.:|     |..|.    ||   ||.:
  Fly  1616 LTDPGRRSDLARKSFILQHQQQHQSN----ISMTEPKFVGSKVEELIQRNEARLSGCSIRYPSLR 1676

  Fly   146 FSRKASSSYSLKLDP---------PGKGKVKAKR---KPLSTPASPSRVRQEPQCTCMSAEQYAR 198
            ...:.       :||         ||...||...   .||:...||....|:   ...||.:..|
  Fly  1677 PGHRI-------IDPQLANILNERPGFLPVKGPTDLDSPLTPILSPPPAFQD---NSRSARRQER 1731

  Fly   199 LRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPR 263
             |...|.:|...||  |.......:|.|..: :|.....|.|.|...:.....| |:...:|..|
  Fly  1732 -RNPGRQQGPLPLP--VPFRSEPQMDPQNPI-NGSAKGMVFSRSFEYDTRRHTP-TDNYVETFSR 1791

  Fly   264 QMKGGQQDRQDVAN--------------SGVNTNTPGVIV---TGVGNVGS-------------- 297
            ...|...||  :.|              |.:..|:|..:.   :|.|:.||              
  Fly  1792 SFDGNLSDR--LLNLAVLAGQRERSPNFSTLTGNSPNYLTKRESGGGSSGSLRSRDSSPKYLHPQ 1854

  Fly   298 ------------------------------------------DMCGQNHVG--SQVGNDDPAACQ 318
                                                      ...|::...  |:||:..|....
  Fly  1855 ATTAYLNAAVKEAPPVYSVPTGSQAKYSPRSRFERTTERSKTHALGRSRKSQFSRVGSAGPLIAH 1919

  Fly   319 -----------MDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNK-DFGDDMTRDAHSHDMHQ 371
                       ...|.|||          |.:.:|.|.::...:.:: |..|....|..|...|:
  Fly  1920 PNTANVGVSRFRSFDTSKS----------QRLNSCDSGARSDLSNDELDNEDGGLNDFLSAGSHK 1974

  Fly   372 HNVINNNT-----------RRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNA 425
            ...|..::           |..|....|.:..||:|::.....|  ||...:||..|::      
  Fly  1975 FPKIGTSSVSVSPFKMQRQRSLTPDRNDSHSSTSSLRKQRSNTP--ESRSLTPEERRKK------ 2031

  Fly   426 NAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNL 490
                           |..:.:||            ....:||:|:.|.| |..|:          
  Fly  2032 ---------------GSQLSLGG------------ARQSSSSRSNTFEG-RQRHD---------- 2058

  Fly   491 YLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSS 555
                       :.:||:           .:.|||:.:....:|:.....:|              
  Fly  2059 -----------DKTPPN-----------ISRSSSSSSYSGGESHEPLNGTG-------------- 2087

  Fly   556 RHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAE-----SYSLHTFEALLSQSMENL 615
                    :..|||:.||.::       .|.|...||..:.|     |.||...|...:::.:::
  Fly  2088 --------STTVTPSAGSGST-------SHRRALTAKQAEQEHRIRRSRSLQLTERSPNRAHKSI 2137

  Fly   616 EFAESLPGSNQRS---PYPLRR--------PNAKSS--------TLPLPPHRPLSTIRDKERDRD 661
            ....:|. ..|||   ||...|        |..::|        ..|.||:   |::|       
  Fly  2138 VNVGALV-PQQRSVGVPYQQSRVPGGGVFPPTIRTSPAGAKIHVNSPAPPN---SSVR------- 2191

  Fly   662 RDGYYSDRNELIRERERERDRGYLSDHNSSFS-------NSRCASCI---GESARAQWFRHSDGW 716
                       :|..|.::.|.:..|:| :||       :||.|...   |:|...|..|.....
  Fly  2192 -----------VRHNETDKARSFDFDYN-NFSRGGGAKGSSRTAHTSGSGGDSGSNQNLRVERES 2244

  Fly   717 RSGSSTI----------GSGSGHGM-MTQQIPGSGHKRSPWDSLPSLRQDSS-LNDSGYKSARA- 768
            ||....|          .:||..|: ..|....||.......|...||:.:| ::.||.:::|: 
  Fly  2245 RSFDDEICEAVLNNNNGSNGSVSGLRFLQPATDSGQVSMASTSSSRLRKSNSPVSASGMEASRSP 2309

  Fly   769 -------DSLEQRAEFIRQDSLRSEY---LSDRESRYGIVQQASI------ESTDSRMCYLT--- 814
                   ::|.|:|   ||......|   |.|.|..|.:::::.|      :|.|..:..:.   
  Fly  2310 QSSGSSTNNLHQQA---RQSGSPQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNR 2371

  Fly   815 -------SSEI---SDDDRM------------SLTTAVSDEDD----------GESVMASPYKAK 847
                   :||:   |::.|:            ||..:....||          |:.:...|....
  Fly  2372 ETINSGGNSELNFMSNETRIYEHPTTVLKSQRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQP 2436

  Fly   848 ATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKG-TTLLFYP-CDSRE 910
            .:.:..:.|..|...:.                              |.|. .|..::| |.:.:
  Fly  2437 RSSSVKAEFLTTATTKS------------------------------CTKTLDTCDYWPRCAACQ 2471

  Fly   911 GRSV--------EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELE---- 963
            .:||        .|:.|.|.::|.  :||          ...|....:......|....||    
  Fly  2472 HKSVSGELKKGPSASGKPLTVLDN--VQP----------HVTSVIVNEDNAVPGPQLRSLEKSNP 2524

  Fly   964 NWV---NSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRH 1025
            :|.   :.|.|.|...     .:|.|.|...:|      |.|.|..::.        |...::|.
  Fly  2525 SWTFLCSGIASICQPV-----QQTETDHSTAQE------AAEEDIVIRK--------VKPNKSRR 2570

  Fly  1026 QIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFH 1090
            ..:::.|. ...|.||         |:|.     :|.|.|             |::|  |.|.  
  Fly  2571 TGRSRSLP-SVMLRRL---------YLAG-----MPKPGS-------------NEMG--TTSD-- 2603

  Fly  1091 AFICARSPSLLNNLLAGRGATKRRPPMLSR----------SNSGSSRRSMQMNSRDEPEKTFK-- 1143
               ||  .||...:.|....|...|.:..:          :|:|||..|..:....:.::|..  
  Fly  2604 ---CA--ASLSQQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRTLNNF 2663

  Fly  1144 -------------VAMPDNA--YSTVYLRDAMSVEEFLASACA-------------RRNLNPMEH 1180
                         .|:.:||  ..|.......|:...:.:..|             :....|:  
  Fly  2664 NNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTASDPGSEAGDTSSGKYRFGPL-- 2726

  Fly  1181 FVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIE 1245
            ..|..|.|....:|     |.|...:....           .|:||::   ::.:..:..|    
  Fly  2727 IWRSSKERRKTKYN-----RRDKCNSGDSG-----------IQIELEQ---DEQYSRATMA---- 2768

  Fly  1246 NAERQDEL--------CCYVSRVEDKSVAMHNGIIKGDEIM---VINGAIVSDLDMMYLESVLQE 1299
             ..||||.        .|.|:..:.:::...|. .|...|:   ::...|...|::.  ||...|
  Fly  2769 -VSRQDEPRAFALTNGSCGVALSKMRAIRRTNS-AKASSILGPFIVKTKIAKHLNIG--ESDKAE 2829

  Fly  1300 EQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMIT--------------- 1349
            .::...:...|.::|..|........|:.||      .:|....:||.|:               
  Fly  2830 RKAPESLPTRSLSQPNGLESYGMGRPDLEDS------DSDSVASNEEAISFYPTTYAEVLYNFTA 2888

  Fly  1350 ----------GLIVP------APGWNGTSK--------DLYSPEAESSPATSFV----------- 1379
                      |:::.      .|.|.|..|        |:..||....| ..||           
  Fly  2889 GGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFP-KEFVRIIHCPETDNF 2952

  Fly  1380 --------DPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENL-LKTAEQETRKSSPTGSV 1435
                    |.||.....|....|.|.|.....|:.|..|.:.:..|: |...|.....|:|:...
  Fly  2953 FIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDF 3017

  Fly  1436 TSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPM-KRETFLSNAEINAL 1499
            .:....:.:.          .|..|.||:|||..|||.|..:.:.||..| ||....|...|..:
  Fly  3018 VAQPDHSTII----------RRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLI 3072

  Fly  1500 FGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASH 1564
            |.||..|..|||:||:.|...::..                 .:...||.....|..||::|.::
  Fly  3073 FSNITAIYKFQRKFLEALRRGIEQN-----------------QVAKVFLKMHKGFLCYSTYCNAY 3120

  Fly  1565 SKAQKVLHPNEGNHALQEFLA-ARNPKQQHSSTLESYLIKPIQRILKYPLLLQQM---------- 1618
            .:|...|...:.....:..|. .|..:......|.::|:.|:|||.:|||.|.::          
  Fly  3121 PRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAK 3185

  Fly  1619 -RNLTD-------TRADEHVHLCE------------ALKGMEKVAEHINEMQRIHEEYGAIFDHL 1663
             .|.||       |...|.:.:.|            ||:.|..:.|.:||.:| |.|       .
  Fly  3186 EGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKR-HSE-------T 3242

  Fly  1664 FRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQK 1728
            ..:||.|                      ..:|     ||..||     ..||..||..:..|||
  Fly  3243 IARHQAS----------------------FQNF-----KGPPLH-----LHSARFFLQVDATRQK 3275

  Fly  1729 KKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWE---------LIHLR----- 1779
            :.|.     |::..:.:...|::....::..|        |||:::         ::::|     
  Fly  3276 QNLW-----NSSYTLFLFDNQLVYCKRDIIKR--------SHFIYKGRIFLDRCRVVNVRDGKMF 3327

  Fly  1780 -----SQLQRRSE---KVYVLSNSTADFRNAFLKTI---RQIIRESVRNMSIPMKNFGGSSGSVS 1833
                 :.|:..||   |.|..|..:|:.::.||.|:   ||               |||.:..||
  Fly  3328 GHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ---------------FGGKALYVS 3377

  Fly  1834 GHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADD 1898
            ..:       |:..|.:  |||        |.:               :...|||       |.|
  Fly  3378 EMT-------GFEYNYE--ERP--------GDY---------------SDQSDYD-------AQD 3403

  Fly  1899 LPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHA 1963
            .       ..|:|.|.|:...|   ...:|:...:.|..     |.:.|.:.             
  Fly  3404 F-------ELATGVTSGESSLP---ESPAKSTSRLCETL-----PKKSQSRD------------- 3440

  Fly  1964 HAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTL 2028
                                               |..|  .|:||                 .:
  Fly  3441 -----------------------------------GISS--AENSQ-----------------IV 3451

  Fly  2029 STTSTLSVGST--GSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVA 2085
            :||||.|:|..  |:..|..:|::...|..|.     .|||.|.....:|:.|.|.::|
  Fly  3452 TTTSTGSLGRRHFGNWFRKPKSANCTPSQSPT-----HKPSFDADATLTEARVAAMELA 3505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674 15/62 (24%)
PH1_Tiam1_2 860..985 CDD:269937 21/141 (15%)
PH 873..974 CDD:278594 20/117 (17%)
TIAM1_RBD 1141..1219 CDD:176413 14/107 (13%)
PDZ_signaling 1221..1308 CDD:238492 18/97 (19%)
RhoGEF 1456..1647 CDD:238091 58/222 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/197 (19%)
PH 1693..1812 CDD:278594 32/143 (22%)
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 10/66 (15%)
RhoGEF 3031..3235 CDD:279015 57/220 (26%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 39/199 (20%)
PH <3285..3363 CDD:278594 15/85 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
32.840

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