DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and CG15611

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_611189.2	Gene:	CG15611 / 36930	FlyBaseID:	FBgn0034194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	102/551 - (18%)
Similarity:	192/551 - (34%)	Gaps:	160/551 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1321 MRVTDDMIDS-----LVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVD 1380
            :.:.||..|:     :|...|..:.|::..:        :|.         ||.|.:.|.:....
  Fly    33 LHILDDNADNGKSIDVVDKAPAKECPLLESQ--------SPS---------SPIATTLPKSQASS 80

  Fly  1381 PAAMAAQLA-VGGVGGVVVGGLGVAKPTSRTSS--FEIENLLKTAEQETRKSSPTGSV----TSS 1438
            ...:..|:: :....|:.:..:.....|:..||  :...|...:....|......|..    ..:
  Fly    81 NGKLEKQISLLDSDSGISLSSINTCSTTAANSSPTYRAPNGFHSFPSHTLSFETLGDEYHEDEDT 145

  Fly  1439 VSTTALTPSRQ--LTDAEKLRKVVMELVDTERTYVKHLNNLLEHY-----LEPMKRETFLSNAEI 1496
            :|...|.|..|  :..::|:..::.||:.||..||.:|...:.:|     :|.:. |......:.
  Fly   146 LSLENLFPCDQTEIYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKDVEDLP-EALSGETKQ 209

  Fly  1497 NALFGNIHEIVTF-QRQFLQ-NLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSS 1559
            ..|.|||.||:.. :::.|. .|....||:..|::|               |..:..|.|..|.|
  Fly   210 KMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEF---------------AAHFEKNSFYCYVS 259

  Fly  1560 FCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRN---- 1620
            |......:.::...|      :.:|.....:.:....::|:|::||||:.:|||||||..:
  Fly   260 FTMGKKSSMQLRQDN------RLWLQTYQTQIKDKLGIDSFLVQPIQRLTRYPLLLQQFISEFYK 318

  Fly  1621 --------LTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDL 1677
                    ||        .:|:....|.:..:.:|:.:.|
  Fly   319 SGISCKPVLT--------AVCKLETRMRRALDVVNQAEEI------------------------- 350

  Fly  1678 SPGDLLYYGGVEWLNISDF--LGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNAT 1740
                    ..:|.||..|.  ||..::..|..|..|.        .:::.|.|
  Fly   351 --------PNIEELNELDVLQLGNFRRATEFDAQHFP--------TRKKYRSK------------ 387

  Fly  1741 NEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLK 1805
                :..:...:..|||:.:..:.:   .|:.||.:.|:..|..      |.||:.        |
  Fly   388 ----VFLFDRCLVCTEVRKKRLAYR---QHYNWEHVELQRPLDS------VSSNAN--------K 431

  Fly  1806 TIRQIIRESVRNMSIPMK----NFGGSSGSV 1832
            .|..::::.....|:..|    :|..:..||
  Fly   432 IINLLVKQEEGGSSVGSKREEYSFMAAEASV 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	47/209 (22%)
		PH2_Tiam1_2	1650..1823	CDD:269957	26/174 (15%)
		PH	1693..1812	CDD:278594	21/120 (18%)
CG15611	NP_611189.2	RhoGEF	167..313	CDD:238091	43/167 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6240
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.790