Protein Alignment sif and CG30456

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_611188.3
• Gene: CG30456 / 36929
• FlyBaseID: FBgn0050456
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 119/592 - (20%)
• Similarity: 209/592 - (35%)
• Gaps: 204/592 - (34%)

  Fly  1296 VLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNG 1360
            :.||..||.::  .:|..|       ...|...|.   ..||..||       ..:.:|..|..|
  Fly   139 IKQERHSLKLL--ENRRHP-------SFEDQSEDH---HTPPATPP-------RRIRLPGLGSRG 184

  Fly  1361 TSKDLYSP-----------EAESSPATSFVDPAAMAAQ--LAVGGVGGVVVGGLGVAKPTSRTSS 1412
            :|:....|           |.|....:.|...:..||:  |.|.....||        |:...:.
  Fly   185 SSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVV--------PSEEVAD 241

  Fly  1413 FEIENLLKTAEQETRKSSPTGSVTSSVSTTAL----------------TPSR------------- 1448
            .:::      :|:.::     |:::..|..||                ||.|
  Fly   242 SKVD------QQQVQR-----SISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLV 295

  Fly  1449 -------QLTDAEK-------------LRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETF--- 1490
                   |..|.|:             :..::.||:.||..||.:|...:|:|....:|:..
  Fly   296 GKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLG 360

  Fly  1491 LSNAEINALFGNIHEIVTFQR-QFLQNLEES-LDLEPDFNKF-----EHCGQFRNVLFAIGSAFL 1548
            |...:.: |||||.:|..|.| :||..|:.: .||:..|::|     :||
  Fly   361 LRGKKYD-LFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHC--------------- 409

  Fly  1549 YYVNHFKLYSSFCASHSKAQKV--LHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKY 1611
                 |..|..|..:..|:.|:  |:.|        :..:...::.....:.|:|::||||:.:|
  Fly   410 -----FYGYVIFTMNKQKSLKLCDLYKN--------YFTSIRLERDDKLGINSFLVQPIQRMARY 461

  Fly  1612 PLLLQQMRNLTDTRADEHV-----HLCEALKGMEKVAEHINEMQRIHEEYGAIFD-HLFRQHQKS 1670
            ||||.|..|......|..:     ..|...|.:..:....||.:.|::    |.| |.|.
  Fly   462 PLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEIIND----IVDCHEFN----- 517

  Fly  1671 CKQPIDLSPGDLLYYGGVEWLNISDFL---GKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKL- 1731
                        :||.| ::..:::|.   .|:|:  ...:..|:|...:::   ..::.|..|
  Fly   518 ------------VYYQG-KFRKVNEFQVLDHKLKR--SYRSKVFIFDKCIIY---TEIKGKNLLF 564

  Fly  1732 --------MGVSSKNAT----------NEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHL 1778
                    :|:|:|..:          .|.|.....|     ::.:.....:||.:::..|   .
  Fly   565 HGRYPCEHIGISAKTKSFTLYYERRKQQECEFTADPV-----QIAIWLDLIRDMINNYANE---E 621

  Fly  1779 RSQLQRR 1785
            |.:||.|
  Fly   622 RQKLQER 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492	4/11 (36%)
		RhoGEF	1456..1647	CDD:238091	51/207 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	28/159 (18%)
		PH	1693..1812	CDD:278594	20/115 (17%)
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	47/172 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840