DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and itsn1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_005171028.1 Gene:itsn1 / 368504 ZFINID:ZDB-GENE-030616-226 Length:1751 Species:Danio rerio


Alignment Length:1399 Identity:258/1399 - (18%)
Similarity:448/1399 - (32%) Gaps:483/1399 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   654 RDKERDRDRDGYYSDRNELIRERERERD--------------------------RGYLSD----- 687
            |:.||.|..:...:.|.||:.:|.||::                          .|.|.|     
Zfish   438 RELERQRQLEWERTRRQELLTQRNREQENIVLLKARKKTLEFELEALNDKKSQLEGKLQDIRSRL 502

  Fly   688 ----HNSSFSNSRCASCIGE-SARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWD 747
                |....:|......|.| ::..|..:.|..|               :::.||   .|:...|
Zfish   503 SIQRHEIETTNKTRELRIAEITSLQQQLQESQQW---------------LSRLIP---DKQCLND 549

  Fly   748 SLPSLRQDS----SLN--------------------DSGYKSARA-----DSLEQRAEFIRQDSL 783
            .|..::|:|    |||                    |:..|..|:     |:...:.:.:|:...
Zfish   550 QLKQVQQNSLHRDSLNSLQRAIEMKESTKQQLKEQLDAVEKETRSKLLEIDAFNTQLKELREIHN 614

  Fly   784 RSEYLSDRESRYGIVQ----QASIESTDSRMCYLTSSEISD---DDRM----------SLTTAVS 831
            :.:....:|....|.|    :.||:|.|||:.. |...:|.   ||.:          :..:.||
Zfish   615 KQQRQKQKELEADITQPSHDRKSIDSQDSRLSG-TDDGVSPAWRDDGLGKAPTPPVSQAWMSRVS 678

  Fly   832 DED--------DGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRG 888
            :|:        |..|.:.:.:.......|.|.::....:..:||         .:.::::...|.
Zfish   679 EEENHSRAEIQDNLSKLFTQHPQAGKIQAQSPWSMADKIPVSGF---------NQEKVKVVYYRA 734

  Fly   889 WKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYL 953
                          .||.::|....:...|..:::|.|                           
Zfish   735 --------------MYPFEARSHDEITIHPGDIVMVKG--------------------------- 758

  Fly   954 FQAPCQVELENWVNSIHSACAAAFARH-RGKTGTL------HLLQEEI---FRLEKAIESDHKL- 1007
                      .||:...:......... :||||..      .:.:.|:   .|...|..|..|| 
Zfish   759 ----------EWVDESQTGEPGWLGGEIKGKTGWFPANYAEKIPESEVPLSLRASAASSSAPKLG 813

  Fly  1008 KHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSR 1072
            .||:....|...         |.||.                   .|.:...:..|.|.......
Zfish   814 SHMSSASSSTTA---------TPILP-------------------VSTEPASIAPPSSAPPPTGP 850

  Fly  1073 PTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGA-------TKRRPPMLSRSNSGSSRRSM 1130
            .:.::       :.||..|......||  |:.:..:.:       |:...|.||..:.|..|:  
Zfish   851 ASSSS-------SASSNWADFSTTWPS--NSAVEKQDSDGWDAWPTQPTQPSLSVPSGGQIRQ-- 904

  Fly  1131 QMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNY 1195
                    ...|..|....:..:..|.....||...|.|     |.|.    |.||    ::|..
Zfish   905 --------RSAFTPATLSGSSPSPVLGQGEKVEGLQAQA-----LYPW----RAKK----DNHLN 948

  Fly  1196 FVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQ--MWGF--------------------- 1237
            |  ::||:|                        |.|||  ||.|                     
Zfish   949 F--NKNDVI------------------------TVLEQQDMWWFGEVQGQRGWFPKSYVKLISGP 987

  Fly  1238 -----SVEA--------------------ELIENAERQDELCCYVSRVEDKSVAMH------NGI 1271
                 |:|:                    ||.| .:..:....|.|:   :.|||:      .|.
Zfish   988 VRKSMSIESGSSDSPPSVKRPSPSLNKPTELGE-GQNSNSNSMYPSK---EYVAMYTYESNEQGD 1048

  Fly  1272 I---KGDEIMVI-------NGAIVSDLDMM---YLESVLQEEQSL-SMMMRSSRTEPPDLVGIMR 1322
            :   :||.|.|.       .|.:...:.:.   |::.  :|.:.| |.....|..:.|:      
Zfish  1049 LTFQQGDVITVTKKEGDWWTGTVSGKIGVFPSNYVKP--KESEGLGSAGKTGSLGKKPE------ 1105

  Fly  1323 VTDDMIDSLVCPPPPTDPPVMSEEMIT---GLIV------PAPGWNGTSK--------------- 1363
                 |..::.|...|     ..|.:|   |.::      |...|.|..:               
Zfish  1106 -----IAQVIAPYTAT-----GAEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1160

  Fly  1364 -DLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRT------SSFEIENLLKT 1421
             .|.||....:..|. .:|..:....||..|       :|:...|::.      ...:|.|:|..
Zfish  1161 VKLLSPSTSKTTPTD-PNPPKLPTPNAVCQV-------IGMYDYTAQNDDELPFGKGQIINVLSR 1217

  Fly  1422 AEQETRKSSPTGSVTSSVS-----TTALTPSRQ----------LTDAEKLRK-VVMELVDTERTY 1470
            .:.:..|....|||....|     ||...||:|          ||..|:.|: .:.||:.||..|
Zfish  1218 EDPDWWKGELNGSVGLFPSNYVKLTTDTDPSQQWCADLHLLDMLTPVERKRQGYIHELIVTEENY 1282

  Fly  1471 VKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQ 1535
            |..|..:.|.:.:|:.....|:..|:..:|.|..|:.....:.|:.|.....:..:         
Zfish  1283 VNDLQLVTETFQKPLLESDLLTEKEVAMIFVNWKELTMCNIKLLKALRVRKKMSGE--------- 1338

  Fly  1536 FRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEF-----LAARNPKQQHSS 1595
             |..:..||......:.|.:.|..||:.......::  .:....:.||     ..|.:|:.: ..
Zfish  1339 -RMPVKMIGDILTAQLPHMQPYIRFCSCQLNGATLI--QQKTDEVPEFKDFVKRLAMDPRCK-GM 1399

  Fly  1596 TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR--------- 1651
            .|.|:|:||:||:.:|||:::.:...|.....:|.||..||:..|::...:||..|         
Zfish  1400 PLSSFLLKPMQRVTRYPLIIKNILENTPESHPDHSHLRLALEKAEELCSQVNEGVREKENSDRLE 1464

  Fly  1652 ---IHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVF 1713
               .|.:...:.:.|......:|     |.|...|:.|.         |.|.|...||:.  |:|
Zfish  1465 WIQAHVQCEGLSEQLVFNSVTNC-----LGPRKFLHSGK---------LYKAKSNKELYG--FLF 1513

  Fly  1714 KSAVVFLCKERLRQKKKLMGVSSK----NATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWE 1774
            ...::      |.|..|.:|.|..    :|.:.::...|:..|.:.||.|:..:....|.. ::.
Zfish  1514 NDFLL------LTQIIKPLGSSGTDKVFSAKSHLQYRMYKTPIFLNEVLVKLPTDPSGDEP-IFH 1571

  Fly  1775 LIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIR 1808
            :.|:        ::||.:...:.:.|.|:::.|:
Zfish  1572 ISHI--------DRVYTIRAESINERTAWVQKIK 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 13/125 (10%)
PH 873..974 CDD:278594 9/100 (9%)
TIAM1_RBD 1141..1219 CDD:176413 17/77 (22%)
PDZ_signaling 1221..1308 CDD:238492 27/154 (18%)
RhoGEF 1456..1647 CDD:238091 45/196 (23%)
PH2_Tiam1_2 1650..1823 CDD:269957 33/175 (19%)
PH 1693..1812 CDD:278594 25/120 (21%)
itsn1XP_005171028.1 EH 15..112 CDD:197477
EH 26..91 CDD:238009
EH 215..293 CDD:197477
EH 226..292 CDD:238009
CENP-F_leu_zip 475..611 CDD:287450 24/153 (16%)
RILP-like <546..645 CDD:304877 20/98 (20%)
SH3_Intersectin1_1 731..790 CDD:212920 13/109 (12%)
INTAP 790..932 CDD:293223 32/188 (17%)
SH3_Intersectin1_2 932..983 CDD:212922 19/89 (21%)
SH3 1034..1085 CDD:302595 10/50 (20%)
SH3_Intersectin1_4 1102..1166 CDD:212926 11/79 (14%)
SH3_Intersectin1_5 1188..1241 CDD:212928 11/59 (19%)
RhoGEF 1272..1452 CDD:279015 44/192 (23%)
PH_ITSN 1478..1609 CDD:270084 31/151 (21%)
PH 1495..1601 CDD:278594 26/129 (20%)
C2_Intersectin 1612..1746 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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