DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Plek

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001020921.1	Gene:	Plek / 364206	RGDID:	1308269	Length:	350	Species:	Rattus norvegicus

Alignment Length:	148	Identity:	38/148 - (25%)
Similarity:	58/148 - (39%)	Gaps:	35/148 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 KRG-----WKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGA-IMQPIPEHPKRDYIFCL 944
            |:|     ||..||.|....:.||.      :..:..||.:|.:.|: :..|..:..||.::..:
  Rat    13 KKGSVFNTWKPMWVVLLEDGIEFYK------KKSDNNPKGMIPLKGSTLTSPCQDFGKRMFVLKI 71

  Fly   945 STAFGDAYLFQAPCQVELENWVNSIHSA--C---AAAFARHRGK----------TGTLHLLQEEI 994
            :|.....:.|||....|.:.||..|..|  |   ...|||...:          .|.|:|..::
  Rat    72 TTTKQQDHFFQAAYLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKD- 135

  Fly   995 FRLEKAI-----ESDHKL 1007
              .||.|     |.|.|:
  Rat   136 --PEKGIKELNLEKDKKV 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	29/119 (24%)
		PH	873..974	CDD:278594	26/98 (27%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Plek	NP_001020921.1	PH1_Pleckstrin_2	3..110	CDD:270113	26/102 (25%)
		PH	6..101	CDD:278594	25/93 (27%)
		DEP_PLEK1	125..223	CDD:239892	9/30 (30%)
		PH2_Pleckstrin_2	239..346	CDD:270114
		PH	245..347	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910