DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Arhgef6

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_008771873.1	Gene:	Arhgef6 / 363509	RGDID:	1359674	Length:	789	Species:	Rattus norvegicus

Alignment Length:	655	Identity:	141/655 - (21%)
Similarity:	230/655 - (35%)	Gaps:	186/655 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1281 NGAIVSDLDMMYL----ESVLQEEQ-------SLSMMMRSSRT------EPPD------------ 1316
            ||.::..|....|    |...||.|       :::..::...|      ||.|
  Rat    61 NGVVLCKLISRLLPGSVEKYCQEPQTEADCIDNINDFLKGCATLQVEVFEPDDLYSGANFSKVLN 125

  Fly  1317 -LVGIMRVTDDMIDSLVC------------------PPPPTDPPVMSEEMIT--------GLIVP 1354
             |:.:.:.|:|.:....|                  ..|.|.|...|||...        .|||.
  Rat   126 TLLAVNKATEDQLSERPCGRSSSLSATTSSQTNPQAAVPSTTPEQQSEEKAAEMTENGSHQLIVK 190

  Fly  1355 AP-GWNGTSKD---------LYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSR 1409
            |. .:..|::|         :|....|.                     ||...|.|     ..|
  Rat   191 ARFNFKQTNEDELSVCKGDIIYVTRVEE---------------------GGWWEGTL-----NGR 229

  Fly  1410 TSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHL 1474
            |..|. .|.::..:...|..||  .......|..||.:....       |:..::|||:.|.|.|
  Rat   230 TGWFP-SNYVREIKPSERPLSP--KAVKGFDTAPLTKNYYTV-------VLQNILDTEKEYAKEL 284

  Fly  1475 NNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNV 1539
            .:||..||.|::....||..|...|.||..|:.|||:...|.|||             |.:....
  Rat   285 QSLLVTYLRPLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEE-------------CSKSPEN 336

  Fly  1540 LFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVL--HPNEGNHALQEFLAARNPKQQHSSTLESYL 1601
            ...:|...|..:.||| :|.::||:|..|..||  |.::    |:.|:..:.........|.:.|
  Rat   337 QHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDD----LERFMENQGASSPGILILTTSL 397

  Fly  1602 IKPIQRILKYPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFR 1665
            .||..|:.||..|||:: |::.||..| |..:.:|:...:.:.....::::..:
  Rat   398 SKPFMRLEKYVTLLQELERHMEDTHPD-HQDILKAIIAFKSLMGQCQDLRKRKQ----------- 450

  Fly  1666 QHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMC--------FVFKSAVVFLCK 1722
            ...:...:||....||     .::.|....|:.::   :..|..|        .:|.|.::.|
  Rat   451 LELQILSEPIQAWEGD-----DIKTLGNVIFMSQV---VMQHGACEEKEERYFLLFSSVLIML-- 505

  Fly  1723 ERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQV-RASSAKDMDSHFLWELIHLRSQLQRRS 1786
                           :|:..:....||..:|:..:.| |....:..|..|  |:      .....
  Rat   506 ---------------SASPRMSGFMYQGKVPIAGMVVTRLDEIEGNDCTF--EI------TGSTV 547

  Fly  1787 EKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQT 1851
            |::.|..|:..||:. :::.:.::.:......|:...    ||.|.|.|||  ..|.|.|..  .
  Rat   548 ERIVVHCNNNQDFQE-WMEQLNRLTKGPASCSSLSKT----SSSSCSTHSS--FSSTGQPRG--P 603

  Fly  1852 LERPK 1856
            ||.|:
  Rat   604 LEPPQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492	8/37 (22%)
		RhoGEF	1456..1647	CDD:238091	58/194 (30%)
		PH2_Tiam1_2	1650..1823	CDD:269957	26/181 (14%)
		PH	1693..1812	CDD:278594	20/127 (16%)
Arhgef6	XP_008771873.1	CH	29..129	CDD:214479	13/67 (19%)
		RhoGEF67_u1	139..184	CDD:293221	7/44 (16%)
		SH3_alphaPIX	186..242	CDD:212993	16/82 (20%)
		RhoGEF	266..443	CDD:238091	58/201 (29%)
		PH_Cool_Pix	474..572	CDD:269932	20/126 (16%)
		PH	491..572	CDD:278594	17/106 (16%)
		RhoGEF67_u2	598..691	CDD:293220	5/13 (38%)
		betaPIX_CC	694..780	CDD:293131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910