Protein Alignment sif and Arhgef19

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_001102162.1
• Gene: Arhgef19 / 362648
• RGDID: 1304766
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 132/609 - (21%)
• Similarity: 219/609 - (35%)
• Gaps: 198/609 - (32%)

  Fly  1312 TEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMS-----------------EEMITGL-------- 1351
            ||||  :|::.....:....:|...|. |..:|                 .|::|.|
  Rat   236 TEPP--MGLLETGQAVQGQALCAQEPR-PQELSGNTRGGLEAQERRRFSASELMTRLHSSLRLGR 297

  Fly  1352 -----IVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGV-GGVVVGGLGV-AKPTSR 1409
                 .:.:....|..::...|..|...|.:.:|..::.|.:.:..| ||:|...|.. .|||..
  Rat   298 STAPRALTSGSGAGVIREGKLPGREPRRAETRMDSVSLPAPVDLNEVQGGLVEPRLDTNDKPTQD 362

  Fly  1410 TSS--------FEIENLL------KTAEQETRKS-------------------------SPTGSV 1435
            |:|        |.:.::|      ..:.:|.|:.                         ||:.|.
  Rat   363 TNSATERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDGAEGAEEGPGPPRANLSPSSSF 427

  Fly  1436 TSSVSTTALTPS--RQLTDAE-------------KLRKVVMELVDTERTYVKHLNNLLEHYLEPM 1485
            .:..||...|.|  :.:.|..             ||::...||:.:|.:|:..|:..:.|:|..:
  Rat   428 RAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSV 492

  Fly  1486 KRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKF-------EHCGQFRNVLFAI 1543
            :....|...:...||..:.|:.:...:||.:||:.  ||.|..:|       .||..||.|
  Rat   493 ELSECLGTQDKQWLFSKLPEVKSTSERFLHDLEQR--LEADVLRFSVCDVVLHHCPAFRRV---- 551

  Fly  1544 GSAFLYYVNH----FKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKP 1604
               :|.||.:    .:.|......:.|...:|...|.:...|     |.|       |.|:||.|
  Rat   552 ---YLPYVTNQAYQERTYQRLLLENPKFPGILARLEESPVCQ-----RLP-------LTSFLILP 601

  Fly  1605 IQRILKYPLLLQQMRNLTD---------TRA----DEHVHLCEA-LKGMEKVAEHINEMQRIHEE 1655
            .||:.:..:|::.:...|.         |:|    .|.|..|.| ::.|::..|.|:..::||.|
  Rat   602 FQRVTRLKMLVENILKRTTPGSQDEDMATKAFSALKELVQECNASVQSMKRTEELIHLSKKIHFE 666

  Fly  1656 YGAIFD------HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIK---KGLELHAMCF 1711
             |.||.      .|.|..:.....|:..:|.                 .|:|   |.:.||
  Rat   667 -GKIFPLISQARWLVRHGELVELAPLPAAPP-----------------AKLKLSSKAVYLH---- 709

  Fly  1712 VFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLI--PVTEVQVRASSAK--DMDSH-F 1771
            :|...:       |..::|.:|             ::.|.:  .:.|:|||..|.|  .:..| |
  Rat   710 LFNDCL-------LLSRRKELG-------------KFAVFVHANMAELQVRDLSLKLQGIPGHVF 754

  Fly  1772 LWELIH---LRSQLQRR----SEK 1788
            |..|:|   .|.||..|    |||
  Rat   755 LLRLLHGQRARHQLLLRARTESEK 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	52/215 (24%)
		PH2_Tiam1_2	1650..1823	CDD:269957	38/160 (24%)
		PH	1693..1812	CDD:278594	28/111 (25%)
Arhgef19	NP_001102162.1	RhoGEF	468..645	CDD:279015	48/197 (24%)
		PH_ephexin	666..792	CDD:269929	36/155 (23%)
		PH	679..786	CDD:278594	32/141 (23%)
		SH3	805..859	CDD:302595

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910