DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Ect2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001102017.2	Gene:	Ect2 / 361921	RGDID:	1308524	Length:	913	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	181/924 - (19%)
Similarity:	317/924 - (34%)	Gaps:	249/924 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1131 QMNSRDEP--EKTFKVA-MPDNAYSTVYLRDAMSVEEFLASACARRN---------------LNP 1177
            :..|.|.|  |..|.|. ...:.::.:|..|...|...:...||:..               ||.
  Rat   115 EFGSLDSPEFENIFVVTDFQTSVFNDLYKADCRIVGPPVILNCAQMGEPLPFSCRPLYCTSMLNL 179

  Fly  1178 MEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNH--EFVEVCM---KILYQVELQRTTLEQMWGF 1237
            :..|...:|:.::......|.|...:|....::.  ..|..|.   |....|.|....:...|
  Rat   180 VLCFTGFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPIMRPGW-- 242

  Fly  1238 SVEAELIENAERQDELC-CYVS---RVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQ 1298
                 :.|..||::|.| |...   |.|.|.....:.|:.                  :|....:
  Rat   243 -----IYEAWERRNEQCFCAADDDFRNEFKVPPFQDCILS------------------FLGFSDE 284

  Fly  1299 EEQSLSMM--MRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPP----VMSEEMITGLIVPAPG 1357
            |:.|:..|  |:.....|   ||..|.|..::|.......|.:|.    |:.:|...|.| ....
  Rat   285 EKHSMEEMTEMQGGTYLP---VGDERCTHLIVDENTVKELPFEPSKKLFVVKQEWFWGSI-QMDA 345

  Fly  1358 WNGTSKDLY----SPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENL 1418
            ..|.:..||    :||.:.|                        |..|.::.|.|......::..
  Rat   346 RAGETMYLYEKANTPELKKS------------------------VSLLSLSTPNSNRKRRRLKES 386

  Fly  1419 LKTAEQET-------RK---------------------------SSPTGSVTSSVSTTALTPSRQ 1449
            |....:||       ||                           .:|.....||.|:|.:.|.:.
  Rat   387 LAQLSRETDLSPFPPRKRPSAEHSLSIGSLLDISNTPDSSIHYGETPKSCAKSSRSSTPVPPKQS 451

  Fly  1450 LTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRE-----TFLSNAEINALFGNIHEIVTF 1509
            ..     .:|..||..||..||..|..:::.:..|::.|     ..|:..||..:||:|.:|...
  Rat   452 AR-----WQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDV 511

  Fly  1510 QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYY-----------VNHFKLYSSFCAS 1563
            ..:...:||   ||..::::..          :||..||.|           ||.|::.......
  Rat   512 HMKIKDDLE---DLIANWDESR----------SIGDIFLKYSKDLVKTYPPFVNFFEMSKEMIIK 563

  Fly  1564 HSKAQKVLHPNEGNHALQEFLAARNPKQQ-HSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRAD 1627
            ..|.:...|         .||.....|.: ...:|...||:|:||:....|||..::..|.....
  Rat   564 CEKQKPRFH---------AFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENP 619

  Fly  1628 EHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLL-----YYGG 1687
            :...|.:|:..:::|..||||.:|..|....|||.::.         :|..|.:||     ....
  Rat   620 DKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYE---------VDGCPANLLSSHRSLIQR 675

  Fly  1688 VEWLNISDFLGKIKKGLELHAMCFVFKSAVVFL---CKERLRQKKKLMGV--SSKNATNEVEIIR 1747
            ||.:::.:           |. |...:...:||   |.|..|::.|::|.  |..:.|.....::
  Rat   676 VETVSLGE-----------HP-CDRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHDRTRPPASLK 728

  Fly  1748 YQVLIPVTEVQVRASSAKDMDSHFLWELI--------HLRSQLQRRSEKV-----------YVLS 1793
            :..|:|:::::......:..|.|..:.|:        ::....|..||::           :|.:
  Rat   729 HIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVAN 793

  Fly  1794 N-STADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQ 1857
            . ..||..|....|..:....:.::|...:..   :|.::...|.:...:..:   |:|   ||:
  Rat   794 TICKADAENLMYVTDPESFEVNTKDMDSTLSR---ASRAIKKTSKKVTRAFSF---SKT---PKR 849

  Fly  1858 QITI-VHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLP-PSVGVVHYASGHTHGQQMQP 1920
            .:.: :..||:      ..|....|:|.:....||.:.....:| ||:..:             |
  Rat   850 ALRMALSSSHS------SEGRSPPSSGKLAVSRLSSTSSLAGIPSPSLVSL-------------P 895

  Fly  1921 AGFRGRSKTVGDVT 1934
            :.|..||.|:...|
  Rat   896 SFFERRSHTLSRST 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	16/98 (16%)
		PDZ_signaling	1221..1308	CDD:238492	17/92 (18%)
		RhoGEF	1456..1647	CDD:238091	48/207 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	36/202 (18%)
		PH	1693..1812	CDD:278594	24/143 (17%)
Ect2	NP_001102017.2	PTCB-BRCT	179..242	CDD:289507	10/62 (16%)
		BRCT	266..341	CDD:278934	18/95 (19%)
		RhoGEF	456..640	CDD:279015	49/205 (24%)
		PH_Ect2	631..804	CDD:269936	39/193 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910