DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Y105E8A.25

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001300405.1 Gene:Y105E8A.25 / 3564893 WormBaseID:WBGene00013682 Length:1619 Species:Caenorhabditis elegans


Alignment Length:1898 Identity:339/1898 - (17%)
Similarity:613/1898 - (32%) Gaps:581/1898 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 STPASPSRVRQEPQCTCMSAEQYARLRTDP-----RVRGSSTLPRNVGSHRITDVDGQQQVGSGK 233
            |.|..||....||              .||     .:...|:.||...::.:|.           
 Worm    10 SLPPLPSSPPPEP--------------VDPTRITFTLSNESSSPRYEFNNLVTS----------- 49

  Fly   234 VVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSD 298
                 ||.|.:    |..|.|:.|...||        ||:.....|.:..|...|          
 Worm    50 -----SSPSYF----SYQPYTSPGIYLLP--------DREQQPYFGADFQTESSI---------- 87

  Fly   299 MCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDFGDDMTRD 363
                    |......|....|.::    |..::|||..:.|   |..|.....       |...:
 Worm    88 --------SWNSPTSPPPPPMIVE----EEMRSGGGTARPV---TPRSIANSL-------DSLSE 130

  Fly   364 AHSHDMHQHNVIN-NNTRRKTKSTEDMNVDT------STLKRMLKPMPSTESPVTSPEMGRRRYN 421
            ...|..|..:|:| |:...:::|..|:...|      .:|:.     .|.::.||:...|     
 Worm   131 CAQHHHHHSDVVNANSNSDRSRSLGDLLAATMQDGNDDSLRN-----GSYDTLVTTTTKG----- 185

  Fly   422 YYNANAAQTLGHPPHMHQHGMAMGMGG----GGGGGHHIM-NNNTMGRASSQSSRFSGSRSSHEI 481
                                     ||    |.|||..:| ..:.|......:|  |.|...|.|
 Worm   186 -------------------------GGLTDSGIGGGLLLMKGEDEMDIMDDHNS--SSSPDHHRI 223

  Fly   482 GRG--------YPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQ- 537
            ...        |||.: :...:....  .||.||    :.|:......|:..|:|..|:.:... 
 Worm   224 PTDISSPDSFTYPPVS-FTSYDPVNG--SGSVPS----YSNENTNPLDSTPRGHSADDRKHSDLP 281

  Fly   538 --QSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYE---MHLRNTLAKGMDAE 597
              ....:|.||....|     :.|:...:.:|.| ..:|..|.::|:.   :|..:..:..:...
 Worm   282 AISEESEHEQQSIHIP-----YNHYPPHSSSVGP-GAAPAVREVVEHTYPMVHCNSAPSNTVFNS 340

  Fly   598 SYSLH----------TFEALLSQSMENLE------FAESLPGSNQRSPYPLRRPNAKSSTLPL-- 644
            ....|          |.....|:.:||::      |.:....:|..|      .:.|.:||..  
 Worm   341 DRIAHRRVVSDDVTETTRLKRSEELENMDKVGRISFEKRSASTNHLS------KSRKGATLVFHN 399

  Fly   645 PPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLS-------------DHNSSFSN-- 694
            .|:....|..::|.:...|||..|...||.|:....:|..::             |::|:.::  
 Worm   400 DPNEKDETDDEEEYEDAADGYSKDNEMLILEKSGGEERYRMASVKKKNGSPLRHFDNHSNLTSIS 464

  Fly   695 ---------SRCASCIGESARAQWFRHSD-GWRSGSSTIGSGSGHGMMT-QQIPGSGHKRSPWDS 748
                     .|..|.:..::|:...|.:| .|:......|. .||.|.: |.:|..       |:
 Worm   465 STEPPPVRLPRRVSAVSSTSRSSPQRATDQSWKDKMPPFGI-VGHSMYSPQSLPSR-------DA 521

  Fly   749 LPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDR--ESRYG----IVQQASIES-- 805
            :|....|.|...||..|....|..|.:..:....      .|.  :|||.    :.:..||.|  
 Worm   522 IPRTPFDGSTISSGASSNIGGSQRQFSHEVTSPD------GDETPDSRYSTSSRLYENHSISSPT 580

  Fly   806 -------TDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVR 863
                   ||..|   ..|||..:.|:|::::::.|..    .:.|.|:::.|...|||     ||
 Worm   581 ALLAAELTDDLM---PLSEICKNHRLSISSSINTEHS----QSPPPKSQSGGAPNSSF-----VR 633

  Fly   864 KAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTL----------LFYPCDSREGRSVEAAP 918
            :    |::|  :.|:..:..:...|.:|    |:..:|          .|.....|.....::..
 Worm   634 R----SLRK--IMKRGSVSTSALGGDEG----LRNGSLKRRASNVSSSFFASAQERLRPRAKSLK 688

  Fly   919 KHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAP-CQVELENWVNSIH----------SA 972
            |          |.|.::.|::.....:..||:.:..:.| .:..|.:.::.:.          .:
 Worm   689 K----------QRIGKNAKKEKSGSDTFTFGNLFRKKPPTSRPNLADIISDLDQRSTTGGRGGGS 743

  Fly   973 CAAAFARHRGKTGTLHLLQ-----EEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQIL 1032
            .:|.....|..:.|:..:.     :.....:.|...|....|::.:   |.......|...:..|
 Worm   744 LSAGATNRRSTSATILPMSSAGGCDPTTPFDSACSLDGLPDHISRM---VSPSDSPHHATSSSTL 805

  Fly  1033 QWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARS 1097
            ....::..|:.:..|:........:.|..:......|.:..||....:..:|.:.......||..
 Worm   806 NGANSMSSLYVQLDRIYGKHDLFANDEYQSWHEKYRHNTLSTKQVKKQDAIFELYLMEKRHCANI 870

  Fly  1098 PSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRD--EPEKTFKV--------AMPDNAYS 1152
            ..||:..       :||  ||..:.  .:::.|.:...|  ||...|.:        .|.:| |.
 Worm   871 AFLLHGY-------RRR--MLDENI--ITKQDMDVLIPDVLEPLLIFHLNVLERITARMKEN-YE 923

  Fly  1153 TVYLRDAMSVE--------------------------EFLASACARRNLNPMEHFVRVKKRRDME 1191
            ...:.|.:|.|                          :.|......:|....|.|.:........
 Worm   924 VGTISDIISEELAIDGGQHTKLCCDAYTDFGVAKERSDVLYHHLMNKNAKFAEFFKKTYSEETFY 988

  Fly  1192 DHNYFVP----------HRNDLIENYLHN-------HEF----VEVCMKILYQVE--LQRTTLEQ 1233
            .|..|.|          ..:.|:|..|.|       |:.    :|...|..::::  |....:..
 Worm   989 KHYDFRPLITKIIGRATKYSLLLETILKNEQPFSEYHDLTKTALETARKFAHKIDGNLSMAHMSM 1053

  Fly  1234 MWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIK-------------------GDEIMV 1279
            .|     .||....:.......|||   |.|||  |..|:                   |:.::.
 Worm  1054 KW-----EELKAQIDSSSATTLYVS---DPSVA--NATIRYTFDLDSLNSATNRKLVHLGEALIK 1108

  Fly  1280 I---------------NGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLV-----GIMRVT 1324
            |               :|..|...|..|:  ||.::..:.::.:|||    .|:     |:|.| 
 Worm  1109 IPVNPVGSGGGTHSSSSGKQVDKKDQCYI--VLFDDIIVILIRKSSR----QLIFMQDQGVMPV- 1166

  Fly  1325 DDMIDSLVCPPPPTDPPVMSEEMITG---LIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAA 1386
                .||:.........:|   :|:|   ::........|.:..:....|.:|..  |.|..:  
 Worm  1167 ----QSLLIRTAARGHSIM---LISGAKPVLFEISFHTSTDRKKWVTLLELAPKN--VPPEGI-- 1220

  Fly  1387 QLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLT 1451
            ::..|...||:...:...:........|:|.:..|                           :|.
 Worm  1221 RITTGDADGVLRDRVAAQQDAEDKWLKELEAIFDT---------------------------RLP 1258

  Fly  1452 DAEKLRKVV---MELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEI----VTF 1509
            :.|.|.|.:   :|..|..|   :|::||      |.|..|.:||....|:.|...|:    |..
 Worm  1259 EEEALAKYLETRLEFFDNVR---EHVSNL------PFKTRTDISNRIREAVKGRFRELRRARVIP 1314

  Fly  1510 QRQFLQNLEESLDLEPDFNKFEHCGQFRNVL---------------FAIGSAFLYYVNHFKLYSS 1559
            ..:.::.:.||.|.:. ::.|:......:||               .|...|....:..|     
 Worm  1315 LNRLVERITESRDADL-WSYFDEKADAADVLEKSSDLSEDSDNSGDSAARGAKPRRIQTF----- 1373

  Fly  1560 FCASHSKAQKVLHPNEGNHALQEFLAARNPKQQH-----------------------SSTLESYL 1601
                |..:|:....| |..|::..|:..|..::|                       |||.:   
 Worm  1374 ----HGTSQQPGSSN-GGGAIESILSENNGIRRHTTVPRMNSDGGSGSSSSAAAAAGSSTTD--- 1430

  Fly  1602 IKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHL-FR 1665
                    :.|        :.|..|.:..::..:.:|..: ....:|:.|  :.||.:...| .|
 Worm  1431 --------RIP--------IPDDVAFDEENISASAQGSAR-GRGDSELDR--KTYGEMLSDLPIR 1476

  Fly  1666 QHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKK 1730
            |..::.:...:|               |.:.:...|:...|.....:.||....|  ||:|....
 Worm  1477 QTMRARRASTNL---------------IKEVISLRKENHLLKNDNALTKSRCALL--ERVRGGGA 1524

  Fly  1731 LMGVSSKNATNEVEIIR----------YQVLIPVTEV--QVRASSAKDMDSHFLWELIHLRSQLQ 1783
            :|..::....:.:|::|          .:||....|:  :.:|..|::.:....|..:..|| ::
 Worm  1525 MMTSTATAVDDSMEMLRKKEKEIRELQQKVLADRDELAEKQKAIDAQEEEIQTKWAALQARS-IE 1588

  Fly  1784 RRSEKVYVLSNST 1796
            ::...::|.|:|:
 Worm  1589 QQQSPMHVRSSSS 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 21/145 (14%)
PH 873..974 CDD:278594 15/121 (12%)
TIAM1_RBD 1141..1219 CDD:176413 20/132 (15%)
PDZ_signaling 1221..1308 CDD:238492 21/122 (17%)
RhoGEF 1456..1647 CDD:238091 41/235 (17%)
PH2_Tiam1_2 1650..1823 CDD:269957 30/160 (19%)
PH 1693..1812 CDD:278594 23/116 (20%)
Y105E8A.25NP_001300405.1 RhoGEF 852..1043 CDD:238091 34/202 (17%)
PH_16 1095..1211 CDD:375371 22/129 (17%)
OmpH <1540..>1591 CDD:214922 9/51 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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