DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and akap13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_009296114.1 Gene:akap13 / 327519 ZFINID:ZDB-GENE-030131-6253 Length:2553 Species:Danio rerio


Alignment Length:2557 Identity:487/2557 - (19%)
Similarity:835/2557 - (32%) Gaps:752/2557 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 VKAKRKPLSTPASPSRVRQEPQCTCMSAEQYAR----------LRTDPRVRGSSTLP-------- 212
            :.||:   ...:.|.:.:||.|..|....:..:          |:.....:....||        
Zfish   418 ISAKQ---GVASQPDKGKQEEQEACQKRSETEKDYNTESGNLGLQDMGHAQSQGLLPTETGQPTQ 479

  Fly   213 RNVGSHRITDV--------------DGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPR 263
            |.|.|...|||              ...|::.|  ..||:||.:|..|....|....|    ||.
Zfish   480 REVESEGSTDVCWRGDLPEEREGDMSSNQEIDS--YSSALSSHNLEGNSQHDGETEPQ----LPT 538

  Fly   264 QMKGGQQD-----------------RQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGN 311
            |...|..:                 .:|...|.......|::.|..||:.....|.....:.:..
Zfish   539 QCSEGTDEAKLTLIQVNSEVTLSIRSEDTVISDSVDKPHGLLETETGNLSEHTKGNTESAADLVA 603

  Fly   312 DDPAACQ------MDMDLSKS---EGTQAGGGLH---QSVGTCTSSSKGTGTRNKDFGDDMTRDA 364
            ||.:..|      ::.||.:|   ....|.|.:|   |.:.....:|...|.....|.:.     
Zfish   604 DDASVKQNSGFSVLEGDLLESLSLRPNMAPGPVHKVQQGLSPVPETSSHVGPALDPFSET----- 663

  Fly   365 HSHDMHQHN---------------VINNNT----------------------------------- 379
             :....|.|               .:||:|                                   
Zfish   664 -TESFQQPNQSTQLLETALECEDVSLNNSTGDINAIAGVSVDISAEVSLCQNEGCPPDGSKEEVA 727

  Fly   380 -----------RRKTKSTEDMNV-DTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNA------- 425
                       ..:.:|.||:.| |.|.|....:|...:..|:.|....|..:....:       
Zfish   728 PSERIPDLKELTEEPESVEDIIVSDVSDLDDKSQPFEESSLPIDSECFIRGDFQNDESTVQSSEC 792

  Fly   426 -----NAAQTLGH---PPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSR----------- 471
                 |....||.   ...:.|...::.:       ..::.....|.|::::.:           
Zfish   793 TGGDINVGTLLGEEEATEKIEQPDSSLKL-------VELIPEEYTGDATNENKKIEPEEQSILLP 850

  Fly   472 -FSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYG 535
             ..|.....::....|.:...::...|.:..:...||:  :.:|.|     :.||.:....:|..
Zfish   851 TLQGESGFKDVATEEPVQEREIDSTSEETISDLPDPSE--ITNNDC-----AESNAHCQLSESSK 908

  Fly   536 QQQSSGQHPQQ-------QQGPPQ---RSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTL 590
            :..::...|.:       ....||   ..||            |:.|.....:.:..|:.:.:  
Zfish   909 ESANTSSEPAECVNDLDLSCALPQTEIEGSR------------PSEGPLIDGVTICAEIPIDD-- 959

  Fly   591 AKGMD-AESYSLHTF-EALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTI 653
             ||:| |.:.|..|. |..||..|:... ...|..|:...|.     ||.|||..|.  .||...
Zfish   960 -KGVDMATNMSKTTISEDCLSSPMDTTS-CSVLESSSMSDPL-----NASSSTAELT--SPLDIN 1015

  Fly   654 RDKERDRDRDGYYSDRNELIRERE-----------RERDRGYLSDHNSS---FSNSRCASCIGES 704
            ....:|.:........|.|..|..           .:.....|.:|:.:   .|..:|...|.:.
Zfish  1016 SGLHQDLEHTSPVDIDNGLPEEPPPSDTPDCLNGLHQDSPDSLMEHSGTPQPCSEEQCVDQITDD 1080

  Fly   705 ARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSG--HKRSPWDSLPSLRQDSSLND--SGYKS 765
            :              :|...:..||...:..|..|.  |:.:.........|||.|.:  |...|
Zfish  1081 S--------------TSAEDAADGHQDSSVDIANSEAIHRETETFYSVDASQDSVLQEKKSSSVS 1131

  Fly   766 ARADSLEQRAEFIRQ--------------DSLRSEYLSDRESRYGIVQQASIESTDS-RMCYLTS 815
            :...||....|.||.              |||.|:.|.: :|.:....:.||..|.. .|.|.:|
Zfish  1132 SEIPSLTPSPESIRHKESPSTMRGSASDGDSLFSQDLGE-DSVFNNKAEDSITITSGVSMSYSSS 1195

  Fly   816 SEISDDDRMSL-TTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLS---VKKWLLR 876
            :    ||..|| ||..:.:...|:..:.|::.:.|.|.||..  |....|...|:   .:..:||
Zfish  1196 T----DDSSSLGTTCATPQTGTEAPASDPFQEQPTSTGASGE--TEEEEKKDRLTEVPERSAILR 1254

  Fly   877 KK-HQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDY 940
            .. ..:...|:..| |....|.|.|.:          |..:|      ..|.:.:....| :|..
Zfish  1255 TTIRSLSPFRRHSW-GPGKNLAGETEM----------SQRSA------AQGEVERRSVGH-RRSM 1301

  Fly   941 IFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDH 1005
            .:|.|..            :..||...:..|......|..  |.|...|:|:.:.      ||..
Zfish  1302 SWCPSVV------------LRSENDEMNERSYSLEGLAPE--KEGRKSLVQQRVG------ESSQ 1346

  Fly  1006 KLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGE--LPNPKSLLT 1068
            :.|..:::      ::|.|..: ..:.:.|:..:...|.....:   .|:|||.  :|:.:.:||
Zfish  1347 EPKCPSKV------EKEDRGSL-VSLTEEEQESDLGDCSSLGSQ---KSIQSGRRCVPHSQPILT 1401

  Fly  1069 HVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRR-------PPMLSRSNS--- 1123
            .               :||     :.|.|...|:.:  ||...|||       .|||.:|.:   
Zfish  1402 K---------------SVS-----MVAISQKDLDAM--GRLRPKRRISFSFSISPMLPKSKTLFS 1444

  Fly  1124 -GSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEE----------------------F 1165
             |||       |.||.|.....:....:.|..|   ::|.|:                      :
Zfish  1445 LGSS-------SSDEEEAVRLSSFTGTSGSLEY---SISEEDPGPLRSDSEGKIGGTKVSRTFSY 1499

  Fly  1166 LASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEV----------CMKI 1220
            |.|..:::|....|.....::.||.:|..          ....:.|.|..|          |.|:
Zfish  1500 LKSKMSKKNKQEKEKEKNKERERDAKDKE----------RRASNGHLFTTVMTVPTIPCHQCNKL 1554

  Fly  1221 LYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIV 1285
            :       .|.:.:...:..|::.:..:....:|..|...:.|.                     
Zfish  1555 I-------NTKDSILCTNCNAQVHKGCKESLPVCAKVKMKQQKQ--------------------- 1591

  Fly  1286 SDLDMMYLESVLQEEQSLSMMMRS----SRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEE 1346
                   .::|.....:.|:.:||    :|..|...:.|   .||.       |.|..||..|..
Zfish  1592 -------QQTVTDSASTPSVTLRSKTLPARDRPWSTISI---PDDQ-------PAPLAPPRKSPS 1639

  Fly  1347 MITGLIVPAPGWNGTSKDL----YSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPT 1407
            .|...     ..|..||.:    .:.:.:.:|...|:..:..:..              ..:|.|
Zfish  1640 SIMSF-----NSNPLSKSMSINNIAGQMDDTPLKKFLSQSTDSLH--------------KTSKVT 1685

  Fly  1408 SRTSSFEIE-------NLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQL-TDAEKLRKVVMELV 1464
            ..|.|...|       .|:...|.:. |.....|.:.:|....|   :|| .|..|.:.|:.||:
Zfish  1686 ESTESLTDEGTEMMDSQLMGEFEADA-KELEADSYSFTVDKKFL---KQLKKDVIKRQDVIYELI 1746

  Fly  1465 DTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNK 1529
            .||..:|:.|..:.:.|.:.:.||..|....:..:|..:.:::....||..:|   |:.:.:...
Zfish  1747 QTEMHHVRTLKIMADVYSKGLLREVQLEAQTVEKMFPMLDDVLDLHTQFFSHL---LERKKESGS 1808

  Fly  1530 FEHCGQFRNVLFAIGSAFLYYVNHF---------KLYSSFCASHSKA---QKVLHPNEGNHALQE 1582
            .|. |.|  |:..||...   |:.|         |:|..||..|::|   .|.||..:  ...|.
Zfish  1809 QEE-GGF--VIQRIGDVL---VSQFSGSSAERMKKVYGKFCGRHNEAVNFYKELHTKD--KRFQA 1865

  Fly  1583 FLAAR--NPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEH 1645
            |:..:  :|..:..|..|..|: ..|||.|||:|||::...|....::|..:.:.||.:::|...
Zfish  1866 FIKKKMSSPVVRRLSIPECILL-VTQRITKYPVLLQRILQHTKENEEDHADVSQGLKLVKEVIAA 1929

  Fly  1646 INEMQRIHEEYGAIFDHLFRQHQKSCKQ--------PIDLSPGDLLYYGGVEWLNISDFLGKIKK 1702
            ::.....||:...:.:...|...||..:        ..||..|..|.:.|.  |.:.:..|::| 
Zfish  1930 VDNKVNEHEKKKRLKEVYSRTDNKSIMRMKSGQMFAREDLLRGRKLIHDGP--LQLKNSAGRLK- 1991

  Fly  1703 GLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDM 1767
              ::.|:  :.:..:|||   :.:.:|.:.....:.:|    :|..|.|| |.||      |.:.
Zfish  1992 --DVQAL--LLRDVIVFL---QEKDQKYIFASLDQRST----VISLQKLI-VREV------ANEE 2038

  Fly  1768 DSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSV 1832
            .:.||     :.:.:: :.|.|.|.::|..: ||.::    |:|:|:::::             :
Zfish  2039 KALFL-----ITAGIE-KPEMVEVYTSSKEE-RNTWM----QLIQEAMQSI-------------L 2079

  Fly  1833 SGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEAD 1897
            |..|.:.....|.|..::. :|..|:|.:           |:...|.|..   |...|:..:|..
Zfish  2080 SISSRERDDDEGVPSENEE-DRRLQEIKV-----------KEFRDQLHKR---DEQILTLLEEKV 2129

  Fly  1898 DL---------PPSVGVVHYASGHTHGQQMQPAGFRGR---SKTVGDVTEITCSSPEPHQQQQQQ 1950
            .|         |...|:                  |.|   ..|..|||.     .||..::..:
Zfish  2130 KLFRDMCDCGAPDETGL------------------RNRMLFRATTDDVTR-----GEPIMKEALK 2171

  Fly  1951 QQQQQQLM---------QQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEE 2006
            :.:..|::         |:|...|.....|...|      .......|..:|.:...|.:.|.||
Zfish  2172 EVETLQVLVNDSLGGAVQEGVCAAGHVTLPRRAE------TFGGFDSHQMNISKSKDGDREELEE 2230

  Fly  2007 DSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDES 2071
                     .|.|.||.:...|..||..:                     |:|:....    :|.
Zfish  2231 ---------SAELRRTESDSVLKKTSKTN---------------------PLLLVRRN----NEQ 2261

  Fly  2072 ELESESEVH------AAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQS 2130
            .|:|.:.:|      .|.|...         ..|..|.|.....||        |||...|....
Zfish  2262 VLQSVAHLHDLLNTLQAVVVQQ---------DTFIEDQRHAHPSSR--------HPSISSSTSSL 2309

  Fly  2131 PRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMD 2195
            ...|.:..    .:.|.|.:|....|:..|.    |.|.:::.|.:.|.|.....||      .:
Zfish  2310 SSTSSRPS----SLIEQEKQRSLEKQRQEVA----SLQKQQAAHAEERRRREKQWET------RE 2360

  Fly  2196 KHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQ---TIVENTQQ 2257
            |.|:..|.:            ::|..|:|   |..|....:.:|...|...|.|   ..:.::|:
Zfish  2361 KELTQREMQ------------IQSQEEEA---QRRARQLEEEKQELQSKKEEYQRDLARLRDSQK 2410

  Fly  2258 TVVVDIESPSRPATESDSTGNTT---GPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSP 2319
            .:..:.|...|.|.|...|...|   .||..|.|.|:.::|.|        :|:...::..:.||
Zfish  2411 RLEREREQVQREADELKLTEEVTKNRSPSTTSEDSTKFQSTGS--------LDRDPSEMELSSSP 2467

  Fly  2320 E-----RPASTKVKGGRRQIYISPDRCKSQGSS-----PVRIIKIKSPRTSLSDQGKRLSVCSSR 2374
            .     ....:|.||.....:.|....|||.|.     |.|::::..|:.....:.|:      .
Zfish  2468 SARDFLSRMDSKRKGKNLNPFSSNSSQKSQNSEAQSQMPSRLLQLAKPKEKKDKKKKK------G 2526

  Fly  2375 DNSQDRLSAGRRTPSPRRSSEG 2396
            ...|.:.:..:.|..|..:.:|
Zfish  2527 KGQQSQTADSQSTVVPGATPDG 2548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/128 (17%)
PH 873..974 CDD:278594 18/101 (18%)
TIAM1_RBD 1141..1219 CDD:176413 15/109 (14%)
PDZ_signaling 1221..1308 CDD:238492 7/86 (8%)
RhoGEF 1456..1647 CDD:238091 53/204 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/180 (21%)
PH 1693..1812 CDD:278594 25/118 (21%)
akap13XP_009296114.1 C1 1535..1579 CDD:197519 7/50 (14%)
RhoGEF 1738..1931 CDD:238091 53/204 (26%)
PH-like 1975..2077 CDD:302622 30/133 (23%)
PH 1975..2075 CDD:278594 30/131 (23%)
DUF4200 2328..2427 CDD:290574 26/123 (21%)
CASP_C <2377..2488 CDD:285395 27/121 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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