DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and plekhg4

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_009301619.1 Gene:plekhg4 / 326099 ZFINID:ZDB-GENE-030131-4824 Length:2630 Species:Danio rerio


Alignment Length:2457 Identity:478/2457 - (19%)
Similarity:809/2457 - (32%) Gaps:763/2457 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 DSPWQSSRRRDGHLLSSFRLWAEVFHVSASGAGTVK-------------WQQVSEDLVPVNITCI 72
            :.|.::|  :||..:|.       |||......|::             ::....|...|:.|.:
Zfish   545 NEPVKTS--QDGEPVSR-------FHVDHKPVSTLQPDSQPVITSVNEPFRTSQPDNKSVSTTQL 600

  Fly    73 QDSPECIFHITAYNSQVDKILD-------VRLVQPGT---RIGQASECFVYWKDPMTNDTWGLNF 127
            ...|   ..::.:|.|..|.::       |:..||.|   ||.|      :...|::|...|   
Zfish   601 DSKP---VSVSQHNKQESKSVNTSVDNEPVKTSQPDTESLRISQ------FDSKPVSNSQLG--- 653

  Fly   128 TSPIDAKQF-RECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQEPQCTCM 191
            :..:..||. .|..|.....::..|::...:....|....|.:.|.::|     .|..||..|..
Zfish   654 SKQVSIKQLVNEIFSTPQPDNKSVSTTQLERKLVCGSQDNKQESKSVNT-----LVDSEPVKTSQ 713

  Fly   192 SAEQYARL-RTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVA------- 248
            :..:..|: :.|.:...:|.|            || :||...::|:.:.||...||.:       
Zfish   714 TDTELLRISQFDSKPVSNSQL------------DG-KQVSISQLVNEIFSTPQPDNKSVSPTQLD 765

  Fly   249 --------------------SGGPGTNQGADTLPRQMKGGQQDRQDVANSGVN------------ 281
                                ...|.....|||.|  :|..|.|...|:||.::            
Zfish   766 SKLVSTLQDKQESKSVNNSIDNEPVKTSQADTEP--LKRSQFDSNPVSNSQLDGKQVSISQLVNE 828

  Fly   282 -TNTP-----GVIVTGV-GNVG--SDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQ 337
             .:||     .|..|.: ||:.  |.:..:....||. :..|.:...|.:..|:...|....||.
Zfish   829 IFSTPQPDNKSVSTTQLDGNIDRTSQLDSKQESVSQT-DSKPVSISPDNEPVKTSQPQLESTLHP 892

  Fly   338 SVGTCTSS---SKGTGTRNKD---------FGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMN 390
            :....:.|   ::...|...|         :.:|...|.:: |:.......:|....|...::..
Zfish   893 NSKQASMSQLVNEHIQTSQPDLKPVSIAQLYSEDAKPDGYA-DVKPITTELDNGLVSTSQPDNQP 956

  Fly   391 VDTSTLKRMLKPMPSTESP---VTSPEMGRRRYNYYNANAAQTLGHP----PHMHQHGMAMGMGG 448
            |||          |..|..   :|.|| |......|..|...:...|    .|:.|..:      
Zfish   957 VDT----------PQAECTTVNITLPE-GNPNDTSYIVNLPLSTSQPNSKTVHVEQADI------ 1004

  Fly   449 GGGGGHHIMNNNTMGRASSQSSRFS---GSRSSHEIGRGY-------PPRNLYLELERER-SC-I 501
                       |.:..:..::...|   ...:|.::...|       |...:..|.:..| :| :
Zfish  1005 -----------NVINTSQPETEMLSCVLERENSEQVSPAYIELIVSDPYAEVRCESKELRVNCDL 1058

  Fly   502 EGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHP-----QQQQGPPQRSSRHQ--- 558
            |||..|.|   :....|.|.:.|..:.:|....|........|     :|....|.....||   
Zfish  1059 EGSCGSQN---NRASLAETVAESVSSQNQIDQTGNSLYQIHKPIHTPSEQMHDLPTIKEDHQTFS 1120

  Fly   559 ---HHHQQ-----APNVTPTPGSPTSRLLLEYEMHLRNTLAKG--------------------MD 595
               |:..:     :|......||.|:.|..|:...:..|...|                    ::
Zfish  1121 SSSHNTNESVGDLSPIAEEDGGSVTAALYSEHVALVSVTTVPGESPVTLISQGQVGTESPEDRIN 1185

  Fly   596 AESYSLHTFEALLSQSMENL------EFAESLPGSNQRSPYP-------LRRPNAKSSTLPLPPH 647
            .....|.|.|....|::..:      |..|....|.......       .|:...::|...|...
Zfish  1186 QTEVELQTKEERAVQNVAGMPPCKGAEMVEKKSSSEAEIKTDENDVVAVCRQEEVETSQTGLVDA 1250

  Fly   648 RPLSTIRDKER-----DRDRDGYYSDRNELIRERE------RERDRGYLSDHNSSFSNSRCASCI 701
            .|.|.::.:|.     :.|.....|.:.:.:.|.|      ||:: ..::.::.:...|.|:..:
Zfish  1251 TPKSDVQVQEEVSSPVETDEKKQTSVQEKGVEEEEVKAKTVREQE-AIVTSNSENRVQSACSEVL 1314

  Fly   702 GESARAQWFRHSDGWRSGSSTIGSGSGH------------GMMTQQIPGSGHKRSPWDSLPSLRQ 754
                            ..:|.:.:.:||            |.:|::..|.|.:..        ||
Zfish  1315 ----------------DPASDVPNTNGHMHAQDTPTTELKGQITKEEDGKGAEEK--------RQ 1355

  Fly   755 D----SSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTS 815
            :    ||:|.|            :.|..:|..:.|.:....|       ||..:..||.:|:|::
Zfish  1356 EDEIASSVNGS------------QKEHQQQADMDSSFHQQEE-------QACSQKVDSTVCHLSA 1401

  Fly   816 SEISDDDRMSLTTAVSDEDDGESVMASPYKAKA----TGTAASSFNC-TGAVRKAGFLSV----- 870
            ...|:|     .:||..........|.|.|:||    ....:|...| ||...|:|...|     
Zfish  1402 KTESED-----PSAVPSPQPPVDHRAQPVKSKAHDINPDVLSSGVLCLTGTRDKSGHALVTVTMR 1461

  Fly   871 -KKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPE 934
             ..||....:..||.|               ::.|.|.:.  |...:|....::||.....|:|.
Zfish  1462 NTVWLNPNCNSGELVR---------------IMVYFCSTL--RKEVSALGLTVLVDARRCSPVPA 1509

  Fly   935 HPKRDYIF------CLSTA--FGDAYLF-----QAPCQVELENWVNSI----------------- 969
            ..|...|.      |:.|.  ..|..|.     .:..||||...:.|:                 
Zfish  1510 LFKAFNILQEAMPGCIHTVLLLADRDLALRMEKTSSIQVELLTSLKSLYKHVDVSQLPTEFEGTF 1574

  Fly   970 ---HSACAAAFARHRGKTGTLH------LLQEEIFRLEKAI------ESDHKLKHMAELQQSVVT 1019
               ||:..:  .|.|.:..|.|      |||..|.:||..:      |:...|....||.::|:.
Zfish  1575 PYAHSSWVS--FRMRLEQLTSHCEDAVSLLQNTISKLESTVLPPTAEEAQLLLCKYRELMRTVLE 1637

  Fly  1020 DQETRHQIQTQILQWEENLERLHCEQFRLRC---YMASLQS-GELPNPKSLLTH----------- 1069
            |...   ::.| |:....|.||..|:..:..   |..:::| |.|.|....|.|           
Zfish  1638 DSRL---VRLQ-LEGGAALSRLRKEETSVSLTEDYRDAIESAGRLYNQVDELVHRLVMLSNKCTQ 1698

  Fly  1070 ------------------------VSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNL-LAGRG 1109
                                    |......||::| ..::...|     ...|:.... .|...
Zfish  1699 ELEFIMEFKSLEEGFKEVSQWIEEVGESRLQTLSEL-EDSLEQLH-----HKQSIFREFYTAAYE 1757

  Fly  1110 ATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRD----AMSVEEFLASAC 1170
            ..|....:|.|........|.::...:...::|.|.:.|.:......:|    .:.:.||...| 
Zfish  1758 HCKSGEALLKRLEKWEDVSSAELQVYEVKVRSFWVHLRDFSQRVEDTKDKIDKTVQLYEFFDKA- 1821

  Fly  1171 ARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDL--IENYLHNH------EFVEVCMKILYQVELQ 1227
            ....|..|.|...|    .|||.......::.:  :|.|...|      .|.|  ||.| ..||:
Zfish  1822 YEWALEGMRHLACV----SMEDCGMSEKCQSVITCLETYRSQHPPIPDAHFQE--MKDL-AGELK 1879

  Fly  1228 RTTLEQMWGF--SVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDM 1290
            .....:.|.|  |...|..:..|::.|:.....|..|......:...:..::             
Zfish  1880 SEQGLKQWKFAWSKCQETKQMFEKKLEMALRSRRDSDSKSVRSDSSRRNSDV------------- 1931

  Fly  1291 MYLESVLQEEQSLS-----------------MMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPP-- 1336
                |...:|:|.|                 :...||.:..|.....:|:  |..|::..|..  
Zfish  1932 ----STKHQERSSSISFSCRKAFGGAWGRDRLSSHSSTSSTPSSPSGIRL--DARDTVRTPTGSP 1990

  Fly  1337 -------PTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQL------ 1388
                   |...||.|..:...:        .|.:...||.||...:||   |:..:.|.      
Zfish  1991 YSIEHRIPHSTPVRSHRLTRSI--------STDESPQSPHAEGLASTS---PSGTSVQTNRRVLR 2044

  Fly  1389 ---AVGGVGGVVVGGLG-----VAKPTSR--TSSFEIENL-LKTAEQETRKSSPT-------GSV 1435
               :....|...|...|     :::|..|  |..| |:.| :.:.|...|..||.       .|:
Zfish  2045 KTQSFDTAGSEPVSQYGTCQRTLSEPARRGNTGVF-IKGLEVSSTEVIDRPYSPRLPPIHGWSSI 2108

  Fly  1436 TSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSN--AEINA 1498
            .:..|.:....:|  :...|||.:|.|:|.|||.||:.|..::::|...|:|.....:  .:.:.
Zfish  2109 DAHRSGSPAPETR--SKGSKLRHIVDEMVTTEREYVRSLRYIIDNYFPEMERAVLPQDLRGKRSV 2171

  Fly  1499 LFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCA 1562
            :|||:.::|.|..| ||:.||...: .|  .:..||             ||.:.:.|.||:.:..
Zfish  2172 IFGNLEKLVDFHSQYFLKELESCCN-HP--LRVSHC-------------FLRHQDQFSLYALYSK 2220

  Fly  1563 SHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQM-RNLTDTRA 1626
            :..|:..:| .:.||:    |...:..:......|.|||:|||||:.||.|||:.: :.:::.:.
Zfish  2221 NKPKSDTLL-ASHGNN----FFKHKQMELGDKMDLASYLLKPIQRMSKYALLLKDLIKEVSEVQE 2280

  Fly  1627 DEHVHLCEALKGMEKVAEHINE---MQRIHE------EYGAIFDHLFRQHQ-------KSCKQPI 1675
            .|..:|..|.:.::....|.|:   |..|.:      |.|    .|.||.:       |.|::.:
Zfish  2281 QELTYLRAAAEMVKFQLRHGNDLLAMDAIRDCDVNLKEQG----QLVRQDEFTISYGRKKCQRHV 2341

  Fly  1676 DLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNAT 1740
            .|.. ||:.:...:         :|:.||:::.....||:|.|              |::..:..
Zfish  2342 FLFE-DLVLFSKPK---------RIEGGLDVYIYKHSFKTADV--------------GMTETSGE 2382

  Fly  1741 NEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEK--VYVLSNSTADFRNAF 1803
            |.   :|:::                      |        .:||:.|  .|:|.:||||.::|:
Zfish  2383 NS---LRFEI----------------------W--------FRRRTSKNQTYILQSSTADIKHAW 2414

  Fly  1804 LKTIRQII-RESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGY----PGNSQTLERPKQQITIVH 1863
            ...|.:|: :::.||..|.|:..          .|.|:|:..:    |.::...:|....|....
Zfish  2415 TCDIARILWQQATRNKEIRMQEM----------VSMGVGNKPFLDIKPSDAAINDRAIDYIMKGR 2469

  Fly  1864 GSHTL----------GKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQM 1918
            |:.|.          ..|.|::......:|.    .:||...:..|   :|.::.   |.:..|.
Zfish  2470 GARTRASIAVSLFDHSNPFKRAAVNTPVSGT----PVSGGPSSSTL---LGPLNL---HMYSSQS 2524

  Fly  1919 QPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQ 1983
            ..||.|   ..:|                                               |.|.:
Zfish  2525 LLAGER---PLIG-----------------------------------------------PCIEE 2539

  Fly  1984 PHLHHHSSDIERIDPG--TKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLS-VGSTGSQARL 2045
            ..|.|.:|.    .|.  |:|.|                        |::..|| .||:||.:..
Zfish  2540 DELEHETSS----QPSMTTESSG------------------------SSSHCLSGSGSSGSDSGC 2576

  Fly  2046 IQSSHPPA-SYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSG 2096
            :.|..|.| |.:|        .||.:|...| |.....|....||....|:|
Zfish  2577 VSSHLPEALSEEP--------SSPCDSSCYS-SITSPTQEKPCFNSQYISAG 2619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674 26/132 (20%)
PH1_Tiam1_2 860..985 CDD:269937 32/163 (20%)
PH 873..974 CDD:278594 26/133 (20%)
TIAM1_RBD 1141..1219 CDD:176413 19/89 (21%)
PDZ_signaling 1221..1308 CDD:238492 15/105 (14%)
RhoGEF 1456..1647 CDD:238091 55/194 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 37/188 (20%)
PH 1693..1812 CDD:278594 23/121 (19%)
plekhg4XP_009301619.1 COG5099 467..>912 CDD:227430 80/408 (20%)
SEC14 1433..1573 CDD:238099 31/156 (20%)
BAR <1707..>1807 CDD:299863 14/105 (13%)
RhoGEF 2130..2302 CDD:279015 53/192 (28%)
PH_puratrophin-1 2294..2430 CDD:270062 38/196 (19%)
PH 2319..2414 CDD:278594 29/155 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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