DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and quo

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001004109.2 Gene:quo / 321031 ZFINID:ZDB-GENE-030131-9944 Length:1987 Species:Danio rerio


Alignment Length:2287 Identity:409/2287 - (17%)
Similarity:714/2287 - (31%) Gaps:814/2287 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PLMRKAYR--YEDSPW--QSSRRRDGHLLSSFRLWAEVFHVSASGAGTVK--WQQVSE----DLV 65
            |::..:|.  :.:| |  :.:..|.|:.||..        |.:|..|.||  |.:|:.    |..
Zfish   154 PILETSYPCIFTES-WLREINEGRQGNRLSRC--------VLSSDKGVVKVPWTEVANPEFLDRP 209

  Fly    66 PVNITCIQDSPEC---IFHITAYNSQVDKI-------------------------LDVRLVQPGT 102
            ..|:.  .||..|   ...:...|:::..|                         |.|:||:.|:
Zfish   210 KSNVW--PDSKPCSTATIRVRDLNTEISDIESKVVVDFLPLEMETRIVPAIDGLALSVQLVESGS 272

  Fly   103 RIGQASECF---------VYWKDPMTNDTWGLNFTSP-----IDAKQF---RECCSPS------- 143
            |:.:.::..         |.|..|   :||....|..     :|..:|   :|...|:       
Zfish   273 RLVKVNQAHTISSFAGKPVGWVSP---NTWDSRQTQELEGEYVDLLEFNKEKETLVPNKIAMPMK 334

  Fly   144 ---FKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQ-EPQCTCMSAEQY-ARLRTDP 203
               ||..|.|        .|..|..|.......:....||.:.| :|...|...:.| |.||...
Zfish   335 PLGFKLVRTA--------QPSSKSNVSICGVDCNPNKQPSEIMQHDPDSKCRYRQSYMAALRNPV 391

  Fly   204 RVRGSSTLPRNVGSHRITDVDGQQQ---VGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQM 265
            ....:|.||  ......||. |:.:   .|.|..:....|:.::      |...|| ||..|.|.
Zfish   392 NFERASMLP--CLDETRTDA-GKAEPSCEGYGVGLRLQPSSCMF------GQTPNQ-ADRNPMQS 446

  Fly   266 -----------KGGQQDRQDVAN---SGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAA 316
                       |...|..|:|.:   |..|.::|...:|.: ........|:|.....|..|...
Zfish   447 FENSAQQKQSPKNSTQPSQNVPHDRKSRENADSPDQHMTQL-ITSMVQARQHHKSFLTGQPDLPQ 510

  Fly   317 CQMDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDF-----GDDMTRDAH----------S 366
            ..:        ||:|   |......|.:::    .|...|     |....:..|          .
Zfish   511 TVL--------GTKA---LPDKRHPCLNNA----IRQDSFHMRISGQKHAKTQHLPKMGLRALPD 560

  Fly   367 HDMHQHNV---------INNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNY 422
            |..|:|:.         |.::..:.|..||                 .|..|..|....|...:.
Zfish   561 HGGHRHDANLCLQGFSPIQHSQNQPTHITE-----------------QTPQPQISQNPFRNENSL 608

  Fly   423 YNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPP 487
            .:.|......|            .|.|.|....::...:  |:.|:|| .|.|.::.:..:...|
Zfish   609 LDCNVFCDDRH------------CGRGPGSPVQVIKGKS--RSKSRSS-LSVSETARQCLQSNKP 658

  Fly   488 RN-----LYLELERERSCIEG--------SP----PSD--NVMFDNQCYATTPSSSNGNSDQDQS 533
            .|     :|.|:......|.|        ||    |.:  .|....:..|..   .||...|...
Zfish   659 TNRSHSDVYPEIIPMLPAIHGIKHTADLVSPKLNRPQEARKVSLSGKAGAPV---VNGVELQKLQ 720

  Fly   534 YGQQQSSGQHPQQQQG-----PPQRSSRHQ-----------------------HHHQQAPNVTP- 569
            :..|.::||...:.||     .|...|..|                       .:...:|.|:| 
Zfish   721 HSDQPTTGQSVTEIQGIYISQDPTIKSLLQLGIICLPGGRDRAGRAVVEVYGGRNGWISPQVSPL 785

  Fly   570 -----------TPGSPTSRLLL-----------------------EYEMHLRNTLAKGMDAES-- 598
                       .|.|....|.|                       |..:|..:|:...:|.::  
Zfish   786 ELCRLLLYLHSIPRSEVRELGLTVVIDSRKCPLTSVFYKSLLMVQEQALHAVHTILMLVDKDANP 850

  Fly   599 ---------YSLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPN----------------AK 638
                     ..:.|....|.::::..:....|.||     :|....:                |.
Zfish   851 RPEKHPGLQIDVVTSLKALHKTVDGHQLTSDLSGS-----FPYSHEDWLQFHQKLSLFQIELEAA 910

  Fly   639 SSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGE 703
            ||.|    |..:..:..|..|..:     |....|:| :|...:..|.|...........:.:..
Zfish   911 SSLL----HTAIRRLDVKRTDTAK-----DVQSCIQE-QRSSMKMVLEDTRLVALQREGGAILAR 965

  Fly   704 SARAQ-WFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSAR 767
            ..|.: .|.||:.:|....::      ..:..|:..|.|..       .::.:.||         
Zfish   966 MRREESRFAHSEDFRDSLESV------TCLYDQVEESVHTL-------VMKSNQSL--------- 1008

  Fly   768 ADSLEQRAEFI-----RQDSLRS-EYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSL 826
                 |..|.:     .||||.: :...|.|.|.....:...|.|..::     .:...|.:..|
Zfish  1009 -----QHLEHVLLLRETQDSLHTIQKWCDAEERLWQKDKDDAEKTLQKI-----QQRLQDTQTLL 1063

  Fly   827 TTAVSDEDDGESVMASPYKAKATGT---AASSFNC--TG-AVRKAGFLSVKKWLLRKKHQIELAR 885
            ..|..:::.| .::....:.|:.||   ...:|.|  || ..|..|||     |..::.:.:|  
Zfish  1064 RQAKENKERG-MLLIKDVERKSKGTHYPETDAFRCYTTGFKTRMTGFL-----LKAEERKSDL-- 1120

  Fly   886 KRGWKGYWVCLKGTTLL----------------FYPCDSR----EGRSVEAAPKHLIIVDGAIMQ 930
            :.....|..|.:.::|:                ...|.|.    |.|....:|:|......|:::
Zfish  1121 QTSVDLYRFCEEASSLVKECMEYLDHMKSSNSPMSVCWSSLHAFEQRFQHFSPQHFQDRSAALLE 1185

  Fly   931 PIPEHPKRDYIFCLSTAFGDAYLFQAPC---QVELENWVNSIH--------------SACAAAFA 978
            .:|     |.|:..:..       |..|   :..|...:.:.|              |......|
Zfish  1186 RLP-----DGIWMWNAV-------QTQCRDIRQRLSEILQAAHTHKDSQDEAQLNPVSGQTQNRA 1238

  Fly   979 RHRGKTGTLHLLQE-EIFRLEKAIESDHKLKHMAELQQSV-VTDQETRHQIQTQILQWEENLERL 1041
            ..:|...||..||. |..:.|:.:.|....:..:.:|||| .|:|||||..:|:        ::|
Zfish  1239 AEQGDNETLTYLQSAEGSKFEQVMTSSVHEQSASRIQQSVECTEQETRHLHETK--------DKL 1295

  Fly  1042 HCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLA 1106
            |             .:..:.|..:  :|..:..:.|:.|..                        
Zfish  1296 H-------------NASSMHNEST--SHAQQSVQCTVQKAS------------------------ 1321

  Fly  1107 GRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACA 1171
                      ||..:|:.|...||..:|....:::  |...|.  :|.:|.:..::..       
Zfish  1322 ----------MLQETNNTSRNPSMHKDSASHIQES--VQCTDQ--NTSHLHEPQAISH------- 1365

  Fly  1172 RRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEF--------------VEVCMK-IL 1221
                :|.:        |.:::|::...|.:|.:......|:|              .|.|:: ..
Zfish  1366 ----HPSD--------RKLKEHHHKHSHSDDDLRKSGRIHKFGQTAHYKVFIRSQSAESCLRGYR 1418

  Fly  1222 YQVELQRT-TLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIV 1285
            |.:.|.:| ......|.|:|. |.....:.|..|...|....|..:.......|..:...:.|..
Zfish  1419 YNIPLCKTDAAASCVGASLEG-LSSELNQHDSFCSSASGFSQKCSSDCGSEDHGSGVRCSDNAFT 1482

  Fly  1286 SDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITG 1350
            .           |||.                              ||.|          |.|  
Zfish  1483 K-----------QEES------------------------------VCKP----------ECI-- 1494

  Fly  1351 LIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEI 1415
                                                                            :
Zfish  1495 ----------------------------------------------------------------L 1495

  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            ||                      ::|||          ||::::.||:.||:.||:.|..::|:
Zfish  1496 EN----------------------TSTAL----------KLQRIMQELLQTEQEYVRALAYVVEN 1528

  Fly  1481 YLEPMKRETFLSN--AEINALFGNIHEIVTF-QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFA 1542
            |:..::|.....:  .:...:|||:.::..| |..|:|.||..|: :|               |:
Zfish  1529 YMPELERPDVPQDLRGQRGLIFGNLEKLRDFHQHHFIQELELCLE-KP---------------FS 1577

  Fly  1543 IGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQR 1607
            :|..||.:...|.||:.:..:..:::.:|.    .|. ::|...:....:.:..|.|||:||:||
Zfish  1578 VGRCFLKHKESFGLYALYSKNKPRSENLLI----QHG-KDFFKQKQQLLKDALDLSSYLLKPVQR 1637

  Fly  1608 ILKYPLLLQQMRNLTD--TRAD-EHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQK 1669
            |.||.||||.:....:  |.|: :...:..||..::....|.|.:..:.:.||.  |...::..:
Zfish  1638 ISKYSLLLQDLLRECECVTNAELQRTEIHTALNIIQFQLRHGNNLLAMDDIYGC--DVNLKEQGQ 1700

  Fly  1670 SCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGV 1734
            ..:|                    .:||...:| .:.:...|:|:..::|     .:.:|..:| 
Zfish  1701 LIRQ--------------------DEFLLTFRK-KKCYRHIFLFQDLILF-----SKTRKTDVG- 1738

  Fly  1735 SSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADF 1799
                  |:..|  |:.....:::.:..:|.   ||...:|:...|    |:::..|||..::.:.
Zfish  1739 ------NDTYI--YKQSFKTSDIGMTHNSG---DSGLCFEIWFRR----RKTQDTYVLQAASREV 1788

  Fly  1800 RNAFLKTIRQII-RESVRNMSIPM----------KNF----------------------GG---- 1827
            :.::.:.:.:|: .:::.|..|.|          |.|                      ||    
Zfish  1789 KESWTRDLERILWEQAIHNREIRMQERVFMGIGHKPFMDIKPSEMAISDRAINCVLTGRGGVSVL 1853

  Fly  1828 ---SSGSVSGHSSQGMGS-----MGYPGNSQTL-----------------------ERPKQQITI 1861
               |.||.||.||.|..|     .|.|..|...                       :......|:
Zfish  1854 RLNSIGSASGTSSSGSQSSCSSGWGSPSTSAVCPVGGDDVRYIQETSGILEEDDLDQESGNHSTL 1918

  Fly  1862 VHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGH--THGQQMQPAGFR 1924
            |..|.:.|:......:..||..::    :.|  :.:..|..:|..| ...|  |..|....:|.:
Zfish  1919 VASSESSGESVSCFSTSAHSCSSV----IGG--DCEHTPSELGKQH-KQDHLKTTNQTRDQSGSK 1976

  Fly  1925 GRSKTVGDVTEI 1936
            .:| ::|..||:
Zfish  1977 VQS-SIGKSTEV 1987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674 32/169 (19%)
PH1_Tiam1_2 860..985 CDD:269937 27/162 (17%)
PH 873..974 CDD:278594 20/137 (15%)
TIAM1_RBD 1141..1219 CDD:176413 13/91 (14%)
PDZ_signaling 1221..1308 CDD:238492 16/87 (18%)
RhoGEF 1456..1647 CDD:238091 52/196 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 28/183 (15%)
PH 1693..1812 CDD:278594 21/119 (18%)
quoNP_001004109.2 SMC_N <894..>1314 CDD:330553 93/504 (18%)
RhoGEF 1507..1680 CDD:306973 51/193 (26%)
PH_puratrophin-1 1673..1808 CDD:270062 27/178 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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