DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Mcf2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_008771798.1 Gene:Mcf2 / 317598 RGDID:1566098 Length:1110 Species:Rattus norvegicus


Alignment Length:1360 Identity:255/1360 - (18%)
Similarity:431/1360 - (31%) Gaps:487/1360 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   879 HQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLII----VDGAIMQPIPEHPKRD 939
            |::.:|.|.| |.| :||.              ::|..|...|::    ::..:||        |
  Rat    77 HRVRIAEKYG-KNY-LCLL--------------QAVFLAETGLLLQLKDINHFLMQ--------D 117

  Fly   940 YIFCLSTAFG--DAYLFQAP--CQ---------VELENWVNSIHSACAAAFARHRGKTGTLHLLQ 991
            ..| ||...|  :|::...|  |.         .::.|::.||        ||..|......:: 
  Rat   118 IAF-LSGGRGRDNAWIITFPENCNFRCIPEEVIAKVLNYLTSI--------ARQSGSDSRFTII- 172

  Fly   992 EEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCE---QFRLRCYMA 1053
                 |::.:::...||  ..||:...:.....|.:  .:|:....|:|...:   :|....:|.
  Rat   173 -----LDRRMDTWSSLK--ISLQKISASFPGNLHLV--LVLRPTSFLQRTFTDIGFRFSQEDFML 228

  Fly  1054 SLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHA-FICARSPSLLNNLLAGRGAT-KRRPP 1116
            .|....|.:...|||::.  .|....:|| .|:...|: :|      :..|.:.....| |....
  Rat   229 KLPVVMLSSVSDLLTYID--DKQLTPELG-GTLQYCHSEWI------IFRNAIEKFAVTVKEMAQ 284

  Fly  1117 MLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHF 1181
            ||....:                :..:..:||         |..|:||.||....|.:|...: .
  Rat   285 MLQSFGT----------------ELAETELPD---------DIPSIEEILAGRAERYHLLKND-L 323

  Fly  1182 VRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFV-------EVCMKILYQVELQRTTLE------- 1232
            ..|.|...:...|..||   |..||...:||..       :...|:|.||....|..:       
  Rat   324 TTVTKEGKVLLMNLQVP---DTEENLSSSHECPQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQ 385

  Fly  1233 -------QMWGFSVE-AELIENAE----RQDEL-------------CCYVSRVEDKSVAMHNGII 1272
                   |:|.|..| .|::...|    :|.||             ...:..::|||..:   :.
  Rat   386 LKMEQYLQLWKFEQEFQEVVTQVEFLLSQQRELGDVTGNLAQVKQRLKKIEILDDKSQEL---LA 447

  Fly  1273 KGDEIMVINGAIVS-------DL------DMMYLESVLQEEQSLSMMMRSSRT------------ 1312
            || .|::::|..::       ||      ::.||..:|..| ..|..::.|||            
  Rat   448 KG-RIVILHGHKLASNHHYALDLICQRCNELRYLSDILVNE-IRSKRIQLSRTFKMHRLLQQARQ 510

  Fly  1313 ------------------EPPDLVGIMRVTDDMI------------------DSLVCPPPPTDPP 1341
                              ...|....::..|:.:                  |.|:.|.......
  Rat   511 CCDQGECLLANRGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIENLQFEFDVLLSPELKAQMK 575

  Fly  1342 VMSE--EMITGLIVPAPGWNGTSKD---------LYSPEAESSPATSFVDPAAMAAQLAVGGVGG 1395
            .:..  |.|..:..........|||         :.:||:.....|.|..|..:       |:| 
  Rat   576 NIQRKLENIRSVFENQQNAYKISKDRPEGAVQRMIPAPESVMRARTIFFSPKHV-------GIG- 632

  Fly  1396 VVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKL---- 1456
                          .|.|:...:....::..|:.....:|  .|..|..:..:......||    
  Rat   633 --------------YSFFQACKIFSKVKKSWRQIQAQSNV--KVQATQDSQEKNFDQPPKLDSSL 681

  Fly  1457 ----RKVVMELVDTERTYVKHLNNLLEHYLEPMKR-------ETFLSNAEINALFGNIHEIVTFQ 1510
                ..|:.||:.|||.||:.|..:|..|...|..       ...|.|.: :.||||:.||..|.
  Rat   682 DILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKK-DVLFGNMAEIYEFH 745

  Fly  1511 RQ-FLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPN 1574
            .. |:..||:..| .|:               .:|..||.....|::|:.:|.:..:::.:..  
  Rat   746 NNIFMSRLEDCSD-APE---------------RVGPCFLERKEDFQMYAKYCQNKPRSELIWR-- 792

  Fly  1575 EGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGM 1639
              .::...|......|.:|...|:|||:||:|||.||.|||:::...: ...:....|.|||..|
  Rat   793 --KYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYS-KEGEGTTKLKEALDSM 854

  Fly  1640 EKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPI----DLSPGDLLYYGGVE-WLNISDFLGK 1699
            .::.:.:|:                ..||.:....:    ||  |.::..|... |:.......|
  Rat   855 LELLKSVND----------------SMHQTAINGYVGNMNDL--GKMILQGAFSVWVGHRKGATK 901

  Fly  1700 IK-----KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQV 1759
            :|     |.::.|  .|:::.||:| ||.|.         .|....:......::..:.:.|..:
  Rat   902 MKDFARFKPMQRH--LFLYEKAVMF-CKRRF---------ESGEGADRYPSYSFKHCLKMEEAGI 954

  Fly  1760 RASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKN 1824
            ......|.....:|         ....|::|::.....|.:..:||.||.|:.:           
  Rat   955 TEHVKGDNRKFEIW---------YGEKEEIYIVQAPNIDVKMLWLKEIRNILLK----------- 999

  Fly  1825 FGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDN 1889
                                    .|.|...|.|                            .|.
  Rat  1000 ------------------------QQELLTAKTQ----------------------------QDQ 1012

  Fly  1890 LSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQ 1954
            ||   :.|.|||                                            |||..::|:
  Rat  1013 LS---DQDQLPP--------------------------------------------QQQNAEKQE 1030

  Fly  1955 QQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATL 2019
            :.|:....|.|                                     |.|:.|....:|..|.|
  Rat  1031 ETLLNAVEAGA-------------------------------------EVEQASAMMEVREAALL 1058

  Fly  2020 GRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEV 2079
            .:...:.|  |.:.:...:.|:.|   .:.||..|..|  ..|.|:   |.|::.|.|||
  Rat  1059 VQAEANCT--TWNGMLPCTEGTAA---TAEHPCNSLSP--NSDNGE---DRSQMRSMSEV 1108

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 27/122 (22%)
PH 873..974 CDD:278594 24/111 (22%)
TIAM1_RBD 1141..1219 CDD:176413 20/84 (24%)
PDZ_signaling 1221..1308 CDD:238492 27/131 (21%)
RhoGEF 1456..1647 CDD:238091 55/206 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 30/182 (16%)
PH 1693..1812 CDD:278594 23/123 (19%)
Mcf2XP_008771798.1 SEC14 119..259 CDD:214706 33/161 (20%)
SPEC 399..590 CDD:295325 30/195 (15%)
RhoGEF 685..862 CDD:238091 54/198 (27%)
PH-like 869..1000 CDD:302622 28/188 (15%)
PH 884..997 CDD:278594 24/133 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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