DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Plek2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001107652.1	Gene:	Plek2 / 314260	RGDID:	1305786	Length:	353	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	98/464 - (21%)
Similarity:	160/464 - (34%)	Gaps:	148/464 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   862 VRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDG 926
            |.|.||      |:::.|.:     ..||..|..|:..|||:|..:.  ||.| ..||..|::||
  Rat     5 VLKEGF------LVKRGHIV-----HNWKARWFILRQNTLLYYKLEG--GRRV-TPPKGRIVLDG 55

  Fly   927 -AIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLL 990
             .|..|..|:..|..:..|.|.....|..:|..:.|.:.|...|..|.      |.|:.|.:..|
  Rat    56 CTITCPCLEYENRPLLIKLKTRTSTEYFLEACSREERDAWAFEITGAI------HAGQPGKIQQL 114

  Fly   991 QEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASL 1055
                          |.||:..:|..::     :.|:|          ::::|           ..
  Rat   115 --------------HILKNSFKLSPNI-----SLHRI----------VDKMH-----------DT 139

  Fly  1056 QSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSR 1120
            .||..|:|       :....:|..|  .|..||...::      :.:|..|.|........||..
  Rat   140 SSGLRPSP-------NMEQGSTYKK--TFLGSSLVDWL------ISSNFAASRLEAVTLASMLME 189

  Fly  1121 SN--SGSSRRSMQ-MNSRDEPEK---------TF------KVAMPDN-AYSTVYLRDAMSVEEFL 1166
            .|  .....|||. :.|.|..|:         ||      ||:..:. :.||:.|...:..:.:|
  Rat   190 ENFLRPVGVRSMDAIRSGDLAEQFLDDSTALYTFAESYKKKVSSKEEISLSTMELSGIVVKQGYL 254

  Fly  1167 ASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTL 1231
            :....:|....:..||   .|:|....:|:.|.:.|                            .
  Rat   255 SKQGHKRKNWKVRRFV---LRKDPAFLHYYDPSKED----------------------------N 288

  Fly  1232 EQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGI---IKGDEIMVINGAIVSDLDMMYL 1293
            ..:.|||:...|             ||.:||      ||:   :||:....:...|..|....|:
  Rat   289 RPVGGFSLRGSL-------------VSALED------NGVPTGVKGNVQGNLFKVITKDDTHYYI 334

  Fly  1294 ESVLQEEQS 1302
            ::..:.|::
  Rat   335 QASNKAERA 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	36/123 (29%)
		PH	873..974	CDD:278594	30/101 (30%)
		TIAM1_RBD	1141..1219	CDD:176413	16/84 (19%)
		PDZ_signaling	1221..1308	CDD:238492	16/85 (19%)
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Plek2	NP_001107652.1	PH1_Pleckstrin_2	3..113	CDD:270113	37/127 (29%)
		PH	5..95	CDD:278594	31/103 (30%)
		DEP_PLEK2	128..236	CDD:239891	28/143 (20%)
		PH2_Pleckstrin_2	243..353	CDD:270114	26/151 (17%)
		PH	248..352	CDD:278594	25/146 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910