DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Sptb

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006240306.1 Gene:Sptb / 314251 RGDID:1303243 Length:2329 Species:Rattus norvegicus


Alignment Length:2438 Identity:436/2438 - (17%)
Similarity:755/2438 - (30%) Gaps:847/2438 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   559 HHHQQAPNVTPTPGSPTSRLL---LEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAES 620
            :|:.....|....|....:::   :|.|..:........|..::...|...|.|:     :||.|
  Rat   274 YHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSR-----KFANS 333

  Fly   621 LPGSNQR----SPYPLRRPNAKSSTLPLPPHRP--------LSTIRDKERDRDRDGY-------Y 666
            |.|..|:    |.|         .|:..||...        |.||:.:.|..::..|       .
  Rat   334 LSGVQQQLQAFSTY---------RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389

  Fly   667 SDRN---ELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSG 728
            ||.|   |.:.|.|.:|:....|:            .|.:....|..|..|  |..:        
  Rat   390 SDINRAWESLEEAEYQRELALRSE------------LIRQEKLEQLARRFD--RKAA-------- 432

  Fly   729 HGMMTQQIPGSGHKRSPWDSLPSLRQDSSL---NDSGYKSARADSLEQRAEFIRQDSLRSEY--- 787
                         .|..|     |.::..|   ::.||..|..::.:::.|.|..|:...|.   
  Rat   433 -------------MRETW-----LNENQRLVTQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVK 479

  Fly   788 ----LSDRESRYGIVQQASIESTDSRM----CYLTSSEISDDDRMSLTTAVSDEDDGESVMASPY 844
                |:....:.....|..|.:..:.:    .||.....|...|:..|.|:.             
  Rat   480 ALEDLAQELEKENYHDQKRISARKNNILRLWSYLQELLRSRRQRLEATLALQ------------- 531

  Fly   845 KAKATGTAASSFNCTGAVRKAGFLSVK--KWLLR-----KKHQIELARKRGWKGYWVCLKGTTLL 902
              |.......|.:....: ||..||.:  |.||.     :||::..|.        :.::|..: 
  Rat   532 --KLFQDMLHSIDWMDEI-KAHILSAEFGKHLLEVEDLLQKHKLMEAD--------IAIQGDKV- 584

  Fly   903 FYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVEL----- 962
                     :::.||.  |...:|...||......:|.:..|...|.:.....|..:.:|     
  Rat   585 ---------KTITAAT--LQFTEGKGYQPCDPQVIQDRVSHLEQCFSELSNMAAGRKAQLEQSKR 638

  Fly   963 -----------ENWV---NSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIES-----DHKLK 1008
                       |:|:   ..|:|:.      ..||..|..|:.:   |..||.|.     |..||
  Rat   639 LWKFFWEMDEAESWIKEKEQIYSSL------DYGKDLTSVLILQ---RKHKAFEDELRGLDAHLK 694

  Fly  1009 HMAELQQSVVTDQETRH-QIQTQI----LQWEENLERLHCEQFRLRCYMASLQ--------SGEL 1060
            .:.:..:.:|..::..| ||:|::    .|| ::|:.|  ..||.:    .||        .|:.
  Rat   695 QIFQEAEDMVAQKQFGHPQIETRVKEVSAQW-DHLKEL--AAFRKK----DLQDAENFFQFQGDA 752

  Fly  1061 PNPKSLLTHVSR--------PTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPM 1117
            .:.|:.|....|        ..:.....||            .:....|..|...||..:.    
  Rat   753 DDLKAWLQDAHRLLSGEDVGQDEGATRALG------------KKHKEFLEELEESRGVMEH---- 801

  Fly  1118 LSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVY---------LRDAMSVEEFL--ASACA 1171
            |.....|     .....||.|:.|.::......|..|.         |::|:.:....  :.|| 
  Rat   802 LENQAQG-----FPEEFRDSPDVTNRLQALRKLYQQVMAQAELRGHKLQEALDLYTVFGESDAC- 860

  Fly  1172 RRNLNPMEHFVRVK-KRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILY------------- 1222
                   |.::..| |..|..|    :|:..:.:|...|..:.::..||.|.             
  Rat   861 -------ELWMTEKGKWLDQMD----IPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVNLAANNL 914

  Fly  1223 ---------QVELQRTTLEQMWG-----FSVEAELIENAERQDELC--CYVSR--VEDKSVAMHN 1269
                     :|:..:..|.:.|.     .|.:.|.:::|.|.:..|  |..:.  :.||:..:.:
  Rat   915 VESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIVDKTKVVES 979

  Fly  1270 GIIKGDEIMVINGAIVSDLDMMYLE-SVLQEEQSLSMMMRSSR----TEPPDLVGIMRVTDDMID 1329
            ....|.::.   |.|.....:..|| .||.....:|.:.|.|:    :.|.....|.:...|:  
  Rat   980 TKDLGQDLA---GVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPDQKEDIGQRQADV-- 1039

  Fly  1330 SLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPE---AESSPATSFV-DPAAMAAQLAV 1390
                           |:|          |.|....|...|   .|:|...:|: |.....|.|: 
  Rat  1040 ---------------EKM----------WKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLS- 1078

  Fly  1391 GGVGGVVVGGLGVAKPTSRTSSFEIENLLK----------TAEQETRKSSPTGSVTSSVSTTALT 1445
                   :....||......|..|.|.||:          ..:.:..:...:|.......|   .
  Rat  1079 -------MAQKAVASEDMPESLPEAEQLLQQHAAIKEEIDAHKDDYHRVKASGEKVIEGQT---D 1133

  Fly  1446 PSRQLTDAEKLRKVVMELVDTE-----RTYVKHLNNLL------EHYLEPMKRETFLSNAE---- 1495
            |..||....      :|.:||:     |.:....|.|.      |...:..:.|..|||.|    
  Rat  1134 PDYQLLGQR------LEGLDTDWDALWRMWESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLA 1192

  Fly  1496 -------INALFGNIHEIVTFQRQFLQNLEESLD--LEP-DFNKFEHCGQFRNVLFAIGSAFLYY 1550
                   :.|....|.:.    ..||.::|.:.|  |.| |..         |:|.:.|:   .|
  Rat  1193 HLEPPDSLAAAEAGIRKF----EDFLVSMENNRDKVLSPVDSG---------NMLVSEGN---LY 1241

  Fly  1551 VNHFK-----LYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILK 1610
            .|..|     :......::.|||:|....:.|..||.||  :|.|:......:..|..|      
  Rat  1242 SNKIKEKVQLIEDRHMKNNEKAQEVTALLKDNLELQNFL--QNCKELTLWINDKLLTSP------ 1298

  Fly  1611 YPLLLQQMRNLTDTRADEHVHLCE-----------ALKGMEKVAEH------INE-MQRIHEEYG 1657
             .:...:.|||.:........:.|           ..:|.:.:||.      ::| ::.:|:   
  Rat  1299 -DISYDEARNLHNKWMKHQAFMAELASHQGWLENIVAEGRQLMAEKPQFTDVVSERLEALHK--- 1359

  Fly  1658 AIFDHL-----FRQHQKSCKQPIDL---SPGDLLYYGGVEWLNI------SDFLGKIKKGLELHA 1708
             ::|.|     .:..|.|..:..||   :..||     .:|::.      ||.|||....:....
  Rat  1360 -LWDELQTTTKAKTEQLSAARSSDLRLQTHADL-----SKWISAMEDQLRSDDLGKDLTTVNRML 1418

  Fly  1709 MCFVFKSAVVFLCKERLRQ---KKKLMGVSSKNATNEVEIIRYQVLIPV--TEVQVRASSAK--- 1765
            :........|.|.||.|.:   :...:|..:.:....:|.....:|.|:  .:.|:..|.||   
  Rat  1419 VKLKRVEEQVNLRKEELEELFAEAPPLGAEAGDTDMSIEKRFLDLLEPLGRRKKQLELSKAKLQI 1483

  Fly  1766 --DMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGS 1828
              |::...||  :..|..|.:           :||: ...|:|::..::   :|.::        
  Rat  1484 SRDLEDETLW--VEERLPLAQ-----------SADY-GTNLQTVQLFMK---KNQTL-------- 1523

  Fly  1829 SGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGS 1893
            ...:.||:         |.....|.|                     |.:...|..||       
  Rat  1524 QNEILGHA---------PRVEDVLHR---------------------GQELVKAAEID------- 1551

  Fly  1894 QEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLM 1958
              ..|:...:|            .:|.:....|....|.:           |:.::..:.||..:
  Rat  1552 --CQDIEERLG------------HLQSSWDTLREAAAGRL-----------QRLREAHEAQQYYL 1591

  Fly  1959 QQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATL---G 2020
            ..|.|.|.              |.:..|:..|.     :|....||.....:..:|.:.|:   |
  Rat  1592 DAGEAEAW--------------ISEQELYVFSD-----EPPKDEEGAIVMLKRHLRQQRTVEEYG 1637

  Fly  2021 RTPNHLTLSTTSTLSVG-STGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQV 2084
            |....|.....|.||.| ..|.|...:|..   ...|...:||:.    :|...:.|:..|..|:
  Rat  1638 RNIKQLAGRAQSLLSAGHPEGEQIIRLQGQ---VDKQYAGLKDMA----EERRRKLENMYHLFQL 1695

  Fly  2085 AASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEA 2149
                                                               |::.:.:|.:.:|.
  Rat  1696 ---------------------------------------------------KREADDLEQWITEK 1709

  Fly  2150 ERLAASQQVAVVHQHPS-------DQARESG--HKQRRDR---------DRNPTETDATARFMDK 2196
            |.:|:||::.....|.:       |.|||:|  .::|.|.         |...:|....|.:.| 
  Rat  1710 EMVASSQEMGQDFDHVTMLRDKFRDFARETGAIGQERVDNVNSIIERLIDAGHSEAATIAEWKD- 1773

  Fly  2197 HLSDLEQE--NLTDGTCDIVAYMESLREKAF-----------DPQDLAEDTGDHQQNDSSLSPEP 2248
            .|:|:..:  .|.|....::|....|....:           ..::|.||.|.......|.. ..
  Rat  1774 GLNDMWADLLELIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHRELPEDVGLDASTAESFH-RV 1837

  Fly  2249 QTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKI 2313
            .|..|.....:.|.::                        :.::.||....|    ...:|.|.|
  Rat  1838 HTAFERELHLLGVQVQ------------------------QFQDVATRLQTA----YAGEKADAI 1874

  Fly  2314 FKAKSPERPASTKV-----KGGRRQIYISPDRCK---------SQGSSPVRIIKIKSPRTSLSDQ 2364
             ::|..|..|:.:.     .|.|.|:..:.|:.:         |...|.:|.|:           
  Rat  1875 -QSKEQEVSAAWQALLDACAGRRAQLVDTADKFRFFSMVRDLLSWMESIIRQIE----------- 1927

  Fly  2365 GKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCLK 2429
                        :|:|         ||..|....:||:    ..||....::.||:.|   :||:
  Rat  1928 ------------TQER---------PRDVSSVELLLKY----HQGIKAEINTRAKNFS---TCLE 1964

  Fly  2430 KGGP----SHVCS---VETLSPRVSPRGSMD----------HL-------SPDRGMTSSSCLRHS 2470
            .|..    .|..|   .|.|...:|.|..|:          |:       |.|..:..:..:...
  Rat  1965 LGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDRLHMLLEVCQFSRDASVAEAWLIAQE 2029

  Fly  2471 PRSSFDSHGESDHNLDVPHGSRKRSMSAHGSFETGTRPRAQETYQYYPVYDNQTCSDHYVAAAPT 2535
            |..:....|   |.:|    |.::.:..|.:||..|...|:                        
  Rat  2030 PYLASRDFG---HTVD----SVEKLIKRHEAFEKSTASWAE------------------------ 2063

  Fly  2536 GRYGGGTSSRSRLSKSLERSTSRDSTTTSSSYGHRAYGVSPDRNYVVFSSGPLRSQSAENTFSSQ 2600
             |:.           :||:.|:.:.....          :|||  .....|| :.:..|....:.
  Rat  2064 -RFA-----------ALEKPTTLELKERQ----------TPDR--PTEEPGP-QEEEGETAGEAP 2103

  Fly  2601 PIYDPL--------PRHP-PQPLHQPPM--HHQQQQQQQ-------------------------- 2628
            .::...        .|.| ||.|..||:  ||:.:|::.                          
  Rat  2104 QVHHAATERTSPGEERGPWPQDLQPPPLPGHHKDEQEKSVGDERPATEPLFKVLDTPLSEGDEPT 2168

  Fly  2629 --QQQQYMSYAPEMGGYTGCQHDPQGGYQLSSS 2659
              ..|:.:.:..:|.||.|.:||.:|..:.:|:
  Rat  2169 TLPAQRDLGHTVQMEGYLGRKHDLEGPNKKASN 2201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 28/150 (19%)
PH 873..974 CDD:278594 21/124 (17%)
TIAM1_RBD 1141..1219 CDD:176413 15/89 (17%)
PDZ_signaling 1221..1308 CDD:238492 20/118 (17%)
RhoGEF 1456..1647 CDD:238091 47/237 (20%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/196 (19%)
PH 1693..1812 CDD:278594 27/134 (20%)
SptbXP_006240306.1 CH_SPTB-like_rpt1 40..156 CDD:409095
CH_SPTB_rpt2 170..281 CDD:409168 1/6 (17%)
Spectrin 302..411 CDD:395348 27/122 (22%)
Spectrin 422..526 CDD:395348 22/131 (17%)
SPEC 530..742 CDD:238103 52/263 (20%)
SPEC 641..848 CDD:238103 47/243 (19%)
SPEC 745..954 CDD:238103 38/241 (16%)
SPEC 962..1168 CDD:238103 46/252 (18%)
SPEC 1170..1379 CDD:238103 47/237 (20%)
SPEC 1385..1475 CDD:197544 18/94 (19%)
SPEC 1485..1690 CDD:238103 53/317 (17%)
SPEC 1691..1901 CDD:238103 47/291 (16%)
SPEC 1798..2005 CDD:238103 48/275 (17%)
SPEC 2013..>2086 CDD:197544 19/127 (15%)
PH_beta_spectrin 2182..2287 CDD:269975 8/20 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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