DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Plekhg3

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_017449954.1 Gene:Plekhg3 / 314249 RGDID:1308089 Length:1399 Species:Rattus norvegicus


Alignment Length:1420 Identity:302/1420 - (21%)
Similarity:490/1420 - (34%) Gaps:393/1420 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1384 MAAQLAVGGVGGVVVGGLGVAKPTSRT-----SSFEIENLLKTA-------EQETRKSSPTGSVT 1436
            |.|.|....:..|.|.|.....|.|..     |.....:|:.|.       :..:....||||..
  Rat     1 MGALLRKANLPEVTVPGSDARMPVSTALHQDGSQERPPSLMSTTSSSGSSRDSHSAMEEPTGSEA 65

  Fly  1437 SSVSTTALTPSRQLTDAEK------------------------------LRKVVMELVDTERTYV 1471
            |:.:.|.....|.:.::..                              |.:||.|:|:|||.||
  Rat    66 SAQNGTGSPWGRHIPNSNNNSSSWLNMKGPLSPFNGRAGTGPAYHKLSYLGRVVREIVETERMYV 130

  Fly  1472 KHLNNLLEHY-LEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQ 1535
            :.|.:::|.| |:.:.....|...:::||||||..|.....|.|::| :|.:.:|          
  Rat   131 QDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIESIYALNSQLLRDL-DSCNSDP---------- 184

  Fly  1536 FRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESY 1600
                 .|:.|.|:.....|.:|:.:|.::..:...|.....:....:|...|....|||..|.||
  Rat   185 -----VAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMQDKQQAKFFRDRQELLQHSLPLGSY 244

  Fly  1601 LIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFR 1665
            |:||:||||||.||||::....|...|....:.:|:..|..||.:||:|:|.||       |..|
  Rat   245 LLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHE-------HAVR 302

  Fly  1666 QHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKK- 1729
            . |:.....|:....||..||                .|.|.|...|          .|:|.:: 
  Rat   303 L-QEIQSLLINWKGPDLTTYG----------------ELVLEATFRV----------HRVRNERT 340

  Fly  1730 -----KLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKV 1789
                 |::.::.|...:.|    |:..||.:.:.:..|:...:    .:.:.|     .:.|::.
  Rat   341 FFLFDKILLITKKRGDHFV----YKGHIPCSSLMLIESTRDSL----CFTVTH-----YKHSKQQ 392

  Fly  1790 YVLSNSTADFRNAFLKTIRQIIRESVRNMSIP------------------------MKNFGGSSG 1830
            |.:...|.:.:.::...|:::|.|: .:.:||                        ||....|..
  Rat   393 YSIQAKTVEEKRSWTHHIKRLILEN-HHATIPQKAKEAILEMDSYYPSRYRCSPERMKKAWSSQD 456

  Fly  1831 SVSGHSSQGMGSMGYPGNS----QTLERPKQQITIVHGSHTLG-KPKKKSGSQRHSAGNIDYDNL 1890
            .||.|..||. ....||.:    .||  |.:|    .|....| |.::||...||..        
  Rat   457 EVSAHVRQGR-RQSEPGRTLFSRATL--PSRQ----QGFEMPGLKGRRKSEPTRHLL-------- 506

  Fly  1891 SGSQEADDLPPSVGVVHYASGHT--------HGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQ 1947
              .|.::.:..:.|:.|..|...        |.|..||.......:.:.:..||.          
  Rat   507 --RQLSEKVARAAGMKHAGSAGALLDFGQLPHAQDQQPEAEEAAREELEEEEEIV---------- 559

  Fly  1948 QQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERID----PGTKSEGEEDS 2008
            ::::|||||..                     |:....|..|..: |::.    ||::.|.||:.
  Rat   560 EEEEQQQQQTF---------------------PVSLEDLAGHGGN-EKVPGPELPGSEEEEEEEE 602

  Fly  2009 QQGTIRPKATLGRT-----------PNHLTLSTTSTLSVG-----STGSQARLIQSSHPPASYQP 2057
            ........|....:           .|.|..|..   ::|     |.||::....|...|.|.:.
  Rat   603 SLAVAEQVADFASSLLAALHCWHYRANALLFSRG---AMGKRHGESEGSKSCRRPSDRSPTSVEK 664

  Fly  2058 VLMKDLGKPSPDES--ELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLH 2120
            .:..:.....|:||  ::|::.|..|.|.|  |....|.|.....||.   :.....::|:|   
  Rat   665 RMSFESVSSMPEESSEQVETDPEPRAEQEA--FTALEGPSPEEMPSDP---EFPEALETQLH--- 721

  Fly  2121 PSPRQSPRQSPR-----QSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDR 2180
                     .|:     ..|..:::.:|...||..:..:|::         ::..|.|..|..:.
  Rat   722 ---------DPKGLLGVDKPAGEVDFVEPEGSEDLKTLSSEE---------EEEEEMGATQEPES 768

  Fly  2181 DRNPTETDATARFMDKHLSDLEQEN---LTDGTCD------IVAYMESLREKAFDPQDLA--EDT 2234
            ...|:..|..:...::..|...:.:   ..||.|.      :::...|:.......:.||  ..|
  Rat   769 LLPPSVLDQASVIAERFASSFSRRSSLAAEDGKCSGLGTPRLISRSSSVLSLEGSEKGLARWSST 833

  Fly  2235 GDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSE--RSGDETEEEATTS 2297
            ||...|    .|.|:.|:    .|..|....||...|||.|.|:.. |:|  ||..:.:|.|.::
  Rat   834 GDSLSN----PPAPEVII----GTDTVTDTGPSVNGTESLSAGSGC-PTELDRSSCKKKESALST 889

  Fly  2298 SLASHIVVIDKK-VDKI--FKAKSPERPASTKVKGGRRQIYI-------SPDRCKS---QGSSPV 2349
            .        |:: :|:|  :...:....||..::......||       |..|..|   ..|.|.
  Rat   890 R--------DRQLLDRIKSYYENAEHHDASFSIRRRESLSYIPKGLVRNSVSRFNSLPKPDSEPA 946

  Fly  2350 RIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGIL--- 2411
            ..:..|.|.             |||..|.....    .|.|.|:.||          ||..:   
  Rat   947 APVGYKRPG-------------SSRPASWTLFD----LPGPSRADEG----------DPAPITDA 984

  Fly  2412 --KPPSSPAK----SKSPDRSCLKKGGPSHVCSVETLSPRVSPRGSMDHLSPDRGMTSSSCLRHS 2470
              :|.|..||    .:|.:||.....|.|.....|...|.....   :|   :.|..:......|
  Rat   985 EFRPSSEIAKIWERMESSERSPRTGSGQSQANGFELQEPLFILE---EH---ELGAITEESAVAS 1043

  Fly  2471 PRSSFDSHGESDHNL--DVPHGSRKRSMSAHGSFETGTRPRAQE----------------TYQYY 2517
            |.|:..:...|..:|  ::....::.|....|...|...||..:                .||..
  Rat  1044 PESASPTEHPSPAHLARELKELVKELSSGVQGELVTPLHPRIMQLSHVMDSHVSERVKNKVYQLA 1108

  Fly  2518 PVYDNQTCSD-------HYVAAAP---------------TGRYGGGTSSRSRLSK--SLERSTSR 2558
            ..|..:..:.       |:..|.|               .|...||.:.|..:..  |.|:..::
  Rat  1109 RQYSLRIKNIKAARPPLHWEKATPDGDEPIPSNSGLPVEAGELSGGKARRKPVLSLLSYEQLVAQ 1173

  Fly  2559 DSTTTSSSYGHRAYGVSPDRNYVVFSSGPLRSQSAENTFSSQPIYDPLPRHPPQP 2613
            :..|:.||   .|...||.|    ||..|    ||.:..::.|......|.|..|
  Rat  1174 EPGTSKSS---SAVETSPRR----FSFSP----SAVSPRTTSPGSRSSARSPLSP 1217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 61/191 (32%)
PH2_Tiam1_2 1650..1823 CDD:269957 33/202 (16%)
PH 1693..1812 CDD:278594 18/124 (15%)
Plekhg3XP_017449954.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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