DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Psd4

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001128353.1	Gene:	Psd4 / 311785	RGDID:	1310289	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	1107	Identity:	206/1107 - (18%)
Similarity:	341/1107 - (30%)	Gaps:	388/1107 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 RTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQ 264
            |.|.....|...|.::| :|:...:..|        :..||.||.||.:.|.|..|:.:.|
  Rat    55 RPDAHHGDSDVEPSHLG-NRLVHGEASQ--------APASSRSLEDNSSLGSPQQNRSSST---- 106

  Fly   265 MKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGT 329
                                  .:|...|.:.:.||               ...::.:|.|:||.
  Rat   107 ----------------------QVVFWAGILQAQMC---------------VLDLEEELEKTEGL 134

  Fly   330 QAGGGLHQSVGTCTSSSKGTGTRNKDF-GDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDT 393
            :||      :..|....      :||| ||...:.:                 :.|..||...|:
  Rat   135 KAG------LRCCIPPP------SKDFLGDVGLKPS-----------------RPKEDEDSGDDS 170

  Fly   394 STLKRMLKPMPSTESPVTSPEMGRRR--------------------------YNYYNANA-AQTL 431
            |..:...:..|..:.|.:|||.|...                          :.|.|::. .:|.
  Rat   171 SGSEEENQTWPKKKMPGSSPEWGAEEDSIFFDNPLFLESPCSDTSTEGECFSWGYPNSHLDMKTW 235

  Fly   432 GHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFS------------GSRSSHEIGRG 484
            .|.|......:..|.|.........:.:||...:...:..|.            ||.....|
  Rat   236 PHRPQTLDSPLQEGTGLWTQENDLDLGSNTADHSRCSTPPFPVPSYKMHPCLALGSTEGAPI--- 297

  Fly   485 YPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQG 549
            .||..:. |...|.....|||.:.:|  |::   ....|.|..||       .:.:..||.|..|
  Rat   298 VPPDQVG-ETSWEDDVGPGSPKAPSV--DHE---LIQESDNFGSD-------LRPATTHPVQPWG 349

  Fly   550 -----------PPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAK-GMDAESYSLH 602
                       ||...........|.|.::...|...:..   ::..:..|||. |..|
  Rat   350 SQIPQSLSDLAPPLHEDLQDPSRPQKPLISQNGGERDAGC---FQEPMLCTLAPWGSQA------ 405

  Fly   603 TFEALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHR------PLSTIRDKERDRD 661
               :||.         .|.|.|..|...|  ||:..||....|..:      |..|......::|
  Rat   406 ---SLLE---------PSCPESGGRGSGP--RPSPVSSQESSPQDQLHSLKWPQDTSHPSLLEKD 456

  Fly   662 RDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSG 726
            :....|     :::.|.|.....:.:          |.|            .|..||..:::...
  Rat   457 KSELSS-----LKKDETEEVPSLMQE----------AEC------------EDTSRSEDASVTEH 494

  Fly   727 SGHGMMTQQIPGS----GHKRSP---WDSLPSLRQ--DSSLNDSG--------------YKSARA 768
            ..|....:.:|.|    ...:||   |...||..:  :|..||.|              .||..|
  Rat   495 HVHLASAEGLPESPMPPEEAQSPEEDWRPSPSREKMANSIRNDEGAWNLALRLYQLNGFRKSEVA 559

  Fly   769 DSLEQRAEFIRQDSLRSEYLS---------DR---------------ESRYGIVQQ--------- 800
            ..|.:..:|.|  ::...|||         ||               :.|..|:.|
  Rat   560 AHLRKNNDFSR--AVAEAYLSFFQFEGQSLDRALRGFLQALVLSGETQERERILYQFSKRFHYCN 622

  Fly   801 ----ASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGA 861
                .|::|..:..|.:          |.|.|.:..::.|:|:....:.....|..... |....
  Rat   623 PGAFPSVDSVHTLTCAI----------MLLNTDLHGQNIGKSMSCQEFVTNLNGLQDGG-NFPKE 676

  Fly   862 VRKAGFLSVK----KW------------------------------------------LLRKKHQ 880
            :.||.:.|::    :|                                          |.||.|.
  Rat   677 LLKALYWSIRSEKLEWAVDEEDAARPEKDQPSPSAGKISSPFLQLAQDPTMPTYKQGILARKMHH 741

  Fly   881 IELAR-----KRGWKGYWVCLKGTTLLFYPCDSR--EGRSVEAAPKHL----IIVDGAIMQPIPE 934
            ....:     |||||.:...|:|..|.|...:.:  :|.|:..   |:    :.|..::..|...
  Rat   742 DADGKKTPWGKRGWKMFHTLLRGMVLYFLKGEGQWLDGESLVG---HMMDEPVGVHHSLASPATH 803

  Fly   935 HPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFA--------------------- 978
            :.|:.::|.|.||....||||||...|:.:|:..|:.|.|...|
  Rat   804 YTKKPHVFQLRTADWRLYLFQAPTAKEMASWIARINLAAATHSAPPFPAAVGSQRRFVRPILPMG 868

  Fly   979 --------RHRGKTGTLHLLQEEIFRLEKAI-ESDHKLKHMAE--LQQSVVTDQETRHQIQTQIL 1032
                    :||.....|....:::..|::.: |...:.:.:.|  |::..:..::||::...|:|
  Rat   869 PAQSSLEEQHRSHENCLDAASDDLLDLQRNLPERRGRSRELEEYRLRKEYLEHEKTRYETYVQLL 933

  Fly  1033 ------------QWEENL--ERLHCEQFRLRCYMA----SLQSGELPNPKSLLTHVSRPTKNTLN 1079
                        .||:.|  |...|::.|.....:    ||...|.|....:..::|.  :.|..
  Rat   934 VARLHFPLKDLALWEDQLGNEADSCQEPRPSLKKSHSSPSLHQDEAPTTAKVKRNISE--RRTYR 996

  Fly  1080 KL 1081
            |:
  Rat   997 KI 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	41/210 (20%)
		PH	873..974	CDD:278594	34/153 (22%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Psd4	NP_001128353.1	Sec7	536..690	CDD:238100	30/166 (18%)
Psd4	NP_001128353.1	PH_EFA6	724..851	CDD:270107	35/129 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910