DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Prex1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001129190.1 Gene:Prex1 / 311647 RGDID:1306534 Length:1646 Species:Rattus norvegicus


Alignment Length:1310 Identity:249/1310 - (19%)
Similarity:439/1310 - (33%) Gaps:423/1310 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1384 MAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSR 1448
            |.|..:..|.||...||.| |.|.:|..|                |.|..:...|        .|
  Rat     1 MEAPGSGSGDGGGDPGGDG-AHPDARGPS----------------SGPCAAARDS--------ER 40

  Fly  1449 QLTDAEKLRKVVM-ELVDTERTYVKHLNNLLEHYLEPMKR------ETFLSNAEINALFGNIHEI 1506
            ||    :||..|: |::.|||.||..|..|...:|:.:::      :..|:...:..||.||.:|
  Rat    41 QL----RLRLCVLNEILATERDYVGTLRFLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDI 101

  Fly  1507 VTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL 1571
            :...:.||..||..|..||   :.:|         .:|:.||.:.:.|.:|..:|::|.||.::|
  Rat   102 LEVHKDFLAALEYCLHPEP---QSQH---------ELGNVFLKFKDKFCVYEEYCSNHEKALRLL 154

  Fly  1572 HPNEGNHALQEFL---AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLC 1633
            .......|.:.||   .....::.....||.||:.|||||.||||||:::...|..:..:|..:.
  Rat   155 VELNKVPAARAFLLNCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELSKRTPGKHPDHSAVQ 219

  Fly  1634 EALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDF-- 1696
            .||:.|:.|..:|||.:|..|:..|:     .|.|.              :..|.|..|::|.  
  Rat   220 SALQAMKTVCSNINETKRQMEKLEAL-----EQLQS--------------HIEGWEGSNLTDICT 265

  Fly  1697 -------LGKIKKGLELHAMCFVFKSAVVFLCKERLR---QKKKLMGVSSKNATNEVEIIRYQVL 1751
                   |.||..|.......|:|.:.:|: ||.:.|   .||......|.|.:  :.|.|.::.
  Rat   266 QLLLQGTLLKISAGNIQERAFFLFDNLLVY-CKRKSRVTGSKKSTKRTKSINGS--LYIFRGRIN 327

  Fly  1752 IPVTEVQVRASSAKDMDSHFL-----WELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQII 1811
            ..|.||:.......|..|:..     |: ||     .....|.:|....||:.:..:|..   :|
  Rat   328 TEVMEVENVEDGTADYHSNGYTVTNGWK-IH-----NTAKNKWFVCMAKTAEEKQKWLDA---LI 383

  Fly  1812 RESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLER-----PKQQITIVHGSHTLGKP 1871
            ||..:..|:.:                ||....|...::..|:     ..:::.::.     .:.
  Rat   384 REREQRESLKL----------------GMERDAYVMIAEKGEKLYHMMMSKKVNLIK-----DRR 427

  Fly  1872 KKKSGSQRHSAGN------IDYDNLSGSQEADDLPPSV---GVVHYASGHTHGQQMQPAGFRGRS 1927
            :|.|...:...||      ::...:|.::|..:|..::   |::|:.|                 
  Rat   428 RKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS----------------- 475

  Fly  1928 KTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSD 1992
                                .:.|.:.:|:|.:                                
  Rat   476 --------------------DKHQFKNEQVMYR-------------------------------- 488

  Fly  1993 IERIDPGT---KSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPAS 2054
             .|.|.||   :||.|:...:|                               .||....|  :.
  Rat   489 -FRYDDGTYKARSELEDIMSKG-------------------------------VRLYCRLH--SL 519

  Fly  2055 YQPVL------MKDLGKPSPDESELE---SESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQS 2110
            |.||:      :|......|....::   ::.:....:.|.:..:.|.::|  |.....: :::.
  Rat   520 YAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNG--FMHHVLE-KSEF 581

  Fly  2111 RTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHK 2175
            :.:||....|.........|..:..:.|.:::|  ...|:||....|                  
  Rat   582 KDESQYFRFHADEEMEGTSSKNKQLRNDFKLVE--NILAKRLLIPPQ------------------ 626

  Fly  2176 QRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQN 2240
                              .|.:..|||::|            :::..|:.....|||..|     
  Rat   627 ------------------EDDYGFDLEEKN------------KAVVVKSVQRGSLAEMAG----- 656

  Fly  2241 DSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVV 2305
                ....:.|....:..|.:      ||.:|.::..|.:..|.|              ...::|
  Rat   657 ----LQAGRKIYSINEDLVFL------RPFSEVETILNQSFCSRR--------------PLRLLV 697

  Fly  2306 IDKKVDKIFKAKSPERP--ASTKVKG---------GRRQIYISPDRCKSQGSSPVRIIKIKSPRT 2359
            ..|..:.|   |.|:.|  .|.:::|         ||....::...|..|     .|:|:..  .
  Rat   698 ATKAKETI---KIPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQ-----CILKVNG--N 752

  Fly  2360 SLSDQGKRLSVC----------------------SSRDNSQDRLSAGRRTPSPRRSSEGGGILKH 2402
            |:::.| .|.|.                      |..|..|.|.|.|.....|:.......:|  
  Rat   753 SVANDG-ALEVLEHFQAFRSRREEALGLYQWVYHSHEDAQQARASQGAPDEDPQEDDSVLPLL-- 814

  Fly  2403 TTGPDPGILKPPSSPAKSKSPDRSCLK----------KGGPSHVCSVETLSPRVSPRGS------ 2451
            :.||...:.:  .|...|.:.|...|:          .|...||     |...|.|||.      
  Rat   815 SLGPQLSLHE--DSAVVSLTLDNVHLEHGVVYEYVSTAGAKCHV-----LEKIVEPRGCFRLAAK 872

  Fly  2452 -MDHLSPDRGMTSSSCLRHSPRSS-------FDSHGESDHNLDVPHGSRKRSMSAHGSFETGTRP 2508
             ::..:.|..:...:|.|.....|       ::.|...|..|:    |..:.::.:..|....:.
  Rat   873 ILEAFAEDDSLFVQNCGRLMAMGSAIITMSHYEFHNICDTKLE----SIGQRIACYQEFAAQLKS 933

  Fly  2509 RAQETYQYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSRDSTTTSSSYGHR--A 2571
            |....::..|:.|:..|...:   .||..:      .:.:..|..::|.....:.|..:|.:  .
  Rat   934 RVSPPFKQAPLEDHPLCGLDF---CPTNCH------INFMEVSYPKTTPSVGRSFSIRFGRKPSL 989

  Fly  2572 YGVSPDRNYV 2581
            .|:.|::.::
  Rat   990 IGLDPEQGHL 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 60/200 (30%)
PH2_Tiam1_2 1650..1823 CDD:269957 42/189 (22%)
PH 1693..1812 CDD:278594 30/135 (22%)
Prex1NP_001129190.1 RhoGEF 48..234 CDD:279015 59/197 (30%)
PH_Collybistin_ASEF 239..391 CDD:269931 40/182 (22%)
PH 278..384 CDD:278594 26/117 (22%)
DEP 409..489 CDD:295306 14/154 (9%)
DEP_2_P-Rex 501..593 CDD:239887 18/127 (14%)
PDZ 630..697 CDD:214570 17/107 (16%)
PDZ 714..768 CDD:238080 12/61 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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