DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Arhgef26

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_227201.4 Gene:Arhgef26 / 310460 RGDID:1562559 Length:869 Species:Rattus norvegicus


Alignment Length:697 Identity:124/697 - (17%)
Similarity:234/697 - (33%) Gaps:228/697 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1347 MITGLIVPAPGWNGTSKDLYSPEAESSPATSFVD-PAAMAAQLAVGGVGGVVVGGLGVAKPTS-- 1408
            |:.||..|           ..||.|.|.|.:.:| |.::...|........||.|.....|||  
  Rat   279 MVEGLGAP-----------LGPEGEESEADNDIDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSK 332

  Fly  1409 ---RTSSFEIENLLKTAEQ-------------------------------------------ETR 1427
               |.|...::.:::..|:                                           |.:
  Rat   333 KKNRMSQPVLKAVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEEPEPK 397

  Fly  1428 KSSP-------------TGSVTSSVSTTALTPSRQLTDAEKLR-KVVMELVDTERTYVKHLNNLL 1478
            :..|             |.|..|:|....|  |:.::..|:.| :.:.|::.:|.:|:..|..|:
  Rat   398 EQKPEEKIVIHHKPLRSTWSQLSAVKRNGL--SQTVSQEERKRQEAIFEVISSEHSYLLSLEILI 460

  Fly  1479 EHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAI 1543
            ..:.:..:....::..|.:.||.||.::....::|...||               .:.:|.:|..
  Rat   461 RMFKDSKELTDTMTKTERHHLFSNITDVWEASKKFFTELE---------------ARHQNNIFIE 510

  Fly  1544 GSAFL---YYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLE------- 1598
            ..:.:   :..:.|..|..:|.:....|:         .||:.|......::..|.:|       
  Rat   511 DISDIVEKHTASTFDPYVKYCTNEVYQQR---------TLQKLLTTNPSFKEVLSRIESHEDCRN 566

  Fly  1599 ----SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINE----MQRIHEE 1655
                |:||.|:||:.:.|||:..:...|...:.::.....|||.:.|:....||    |:|....
  Rat   567 LPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMM 631

  Fly  1656 YGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFL 1720
            |..           :.:....:.|..|:  ....||        :|:| ||.|   ..:..|:| 
  Rat   632 YTI-----------NSQLEFKIKPFPLV--SSSRWL--------VKRG-ELTA---YVEDTVLF- 670

  Fly  1721 CKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRR 1785
                          |.:.:..:|....:..::.:|                           :::
  Rat   671 --------------SKRMSKQQVYFFLFNDVLIIT---------------------------KKK 694

  Fly  1786 SEKVYVLSN-STADFRNAFLKTIRQIIRESVRN---MSIPMKN-----FGGSSGS--------VS 1833
            ||:.|.::: |..|          |::.||..|   .|.|.||     :...|.:        :|
  Rat   695 SEESYNVNDYSLRD----------QLLVESCDNEELNSSPGKNTSTMLYSRQSSATHLFTLTVLS 749

  Fly  1834 GHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADD 1898
            .|:::.:..:   ..::|.....:.||      .||....|....|.:...::......:::.|:
  Rat   750 NHANEKVDML---LGAETQSERARWIT------ALGHSSGKQPPDRTTLTQVEITRSFTAKQPDE 805

  Fly  1899 LPPSVGVV-----HYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSS 1940
            |...|..|     ....|...|::::. |.||.. .:....||||.:
  Rat   806 LSLQVADVVLIYQRVGDGWYEGERLRD-GERGWF-PMECAKEITCQA 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 39/205 (19%)
PH2_Tiam1_2 1650..1823 CDD:269957 27/176 (15%)
PH 1693..1812 CDD:278594 16/119 (13%)
Arhgef26XP_227201.4 TDA11 140..>348 CDD:293689 20/79 (25%)
RhoGEF 441..620 CDD:279015 38/202 (19%)
PH_ephexin 641..779 CDD:269929 35/212 (17%)
SH3_ARHGEF16_26 791..845 CDD:212871 9/55 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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