DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Fgd2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_038954639.1	Gene:	Fgd2 / 309653	RGDID:	1309840	Length:	707	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	106/453 - (23%)
Similarity:	186/453 - (41%)	Gaps:	88/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1355 APGWNGTSKDLYSPEAE--SSPATSFVDPA--AMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEI 1415
            |||.:......:|||.:  .||......||  |:.::.                :|.|||....:
  Rat    79 APGPHSFEDQPHSPEHQLPLSPEPWEAPPAGEALTSEF----------------RPVSRTYLNSL 127

  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            :|  |.:....|||...|:          :|..:..:.|: ::||.||::||:.||..|:.|.:.
  Rat   128 KN--KLSSGAWRKSCQPGA----------SPGPETQEPEE-KRVVQELLETEQAYVARLHLLDQV 179

  Fly  1481 YLEPMKRETFLSNA----EINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCGQFRNVL 1540
            :.:.:.||...|.|    .:..:|.||..|..|..| ||..|:..:|   |:......|.....|
  Rat   180 FFQELLREASRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVD---DWTATPRIGDVIQKL 241

  Fly  1541 FAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHP-NEGNHALQEFLA-ARNPKQQHSSTLESYLIK 1603
                :.||      |:||.:..:..:|.::|.. .:.:...||.:. .:..:...|.||:.::::
  Rat   242 ----APFL------KMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQRSEASGSLTLQHHMLE 296

  Fly  1604 PIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHIN----EMQRIHEEYGAIFDHLF 1664
            |:|||.:|.|||::.......:|.:......||..:...|:|.|    ||:|:        ..|:
  Rat   297 PVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERL--------QGLW 353

  Fly  1665 RQHQKSCKQPIDLSPGD-LLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQK 1728
            ..:|:...:...:.|.: ||..|.|  |.||     .::...:.....:|.:.::: |..|:.|
  Rat   354 DVYQRLGLEDDIVDPSNTLLREGPV--LKIS-----FRRSDPMERYLVLFNNMLLY-CVPRVLQ- 409

  Fly  1729 KKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYV 1791
               :|...:..|.          |.|..::||..:..:....||........:||.||.:..|
  Rat   410 ---VGAQFQVRTR----------IDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSREEMV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	52/197 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	28/143 (20%)
		PH	1693..1812	CDD:278594	19/99 (19%)
Fgd2	XP_038954639.1	RhoGEF	156..340	CDD:238091	52/196 (27%)
		PH1_FGD2	372..479	CDD:275421	24/110 (22%)
		FYVE_FGD1_2_4	505..569	CDD:277280
		PH2_FGD1-4	591..692	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910