DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Fgd3

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_056574.2	Gene:	Fgd3 / 30938	MGIID:	1353657	Length:	733	Species:	Mus musculus

Alignment Length:	800	Identity:	155/800 - (19%)
Similarity:	275/800 - (34%)	Gaps:	262/800 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1355 APGWNGTSKD----LYSPEAES---SPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSS 1412
            ||..:.::::    :..|..:|   ||::|.........:.:.|.....:   ||:...|:..|.
Mouse    51 APAGDSSTREPSGAMKIPNRDSGIDSPSSSVASENFPCEESSEGSPSPAI---LGLPSETASDSR 112

  Fly  1413 FEIENLLKTAEQETRKS----SPTGSVT-----SSVSTTALTPSRQLTDAEKLRKVVMELVDTER 1468
            ...:|     .||...|    .|...||     ..||.|      |.:|.:||..:..||:.||.
Mouse   113 VPQDN-----PQEEEDSGMGEEPDPKVTLFRPQEDVSLT------QCSDPQKLLHIAQELLHTEE 166

  Fly  1469 TYVKHLNNLLEHYLEPMKRETFLSNAEI-----NALFGNIHEIVTFQRQF-LQNLEESLDLEPDF 1527
            .|||.|:.|.:.:.      |.|:.|.|     ..:|.||..|..|..|| |..|::.:..|.|.
Mouse   167 AYVKRLHLLDQVFC------TKLTEAGIPLEVTTGIFSNISSIYRFHGQFLLPELQKRITEEWDT 225

  Fly  1528 NKFEHCGQFRNVLFAIGSAFLYYVNHFK----LYSSFCASHSKAQKVLHPNEGNHALQEFLAARN 1588
            |  ...|.....|......:..||.:|.    |.|::.....:.:.|:|..:
Mouse   226 N--PRLGDILQKLAPFLKMYGEYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQ------------- 275

  Fly  1589 PKQQ--HSSTLESYLIKPIQRILKYPLLL-----------------QQMRNLTDTRADEHVHLCE 1634
             ||:  .:.||:.::::|:||:.:|.|||                 ::...|..|.||   |...
Mouse   276 -KQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPRDAPDRKDAERSLELISTAAD---HSNA 336

  Fly  1635 ALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGK 1699
            |::.|||    ::::..::|:.|.             ::.|.....:|:..|.::.|:
Mouse   337 AIRKMEK----MHKLLEVYEQLGG-------------EEDIVNPANELIKEGSIQKLS------- 377

  Fly  1700 IKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSA 1764
            .|.|.......|:|.:.::: |..:||...:.:.|..|              :.::::||
Mouse   378 AKNGTTQDRHLFLFNNVMLY-CVPKLRLMGQKLSVREK--------------MDISDLQV----- 422

  Fly  1765 KDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSS 1829
            :|:                       |..|:...|          ||....|::.:
Mouse   423 QDI-----------------------VKPNAACTF----------IITGRKRSLEL--------- 445

  Fly  1830 GSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYD---NLS 1891
                              .::|.|..|:.|.::..  |:.|.|:||.:.|...|....|   .||
Mouse   446 ------------------QTRTEEEKKEWIQVIQA--TVEKHKQKSETFRAFGGACSQDEEPTLS 490

  Fly  1892 GSQE------------ADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVT---------- 1934
            ..|.            ||....:.|:....|.....:..:..|.:...:|...:|
Mouse   491 PDQPVMSTSSVEPAGVADSNGGTPGIESRKSSSKTRRDKEKPGCKSCGETFNSITKRRYRCKLCG 555

  Fly  1935 EITCSSPEPHQQQQQQQQQ--QQQLMQQGHAHAHPHPHPHPREPPPPPIRQP-HLHHHSSDIERI 1996
            |:.|......:.:..:|.:  ::..:::            |..||.|....| .|..::.....:
Mouse   556 EVICRKCSEFKAENSKQSRVCRECFLEE------------PLVPPSPSSETPTELKQNAEKPPSV 608

  Fly  1997 DP------GTKSEGEEDSQQGTIRPKATLGRTPNH----LTLSTTSTLSVGSTGSQA-RLIQSSH 2050
            ||      ||.:..::             |.|.|.    :..|....|.: ..|||| ||:.|.
Mouse   609 DPRPSLLCGTLNLSDD-------------GTTWNEVWAAIPESDPQVLDL-LAGSQAGRLLYSI- 658

  Fly  2051 PPASYQPVLMKDLGKPSPDE 2070
                  |:...::..|.|:|
Mouse   659 ------PLSGCNITMPDPEE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	55/219 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	24/172 (14%)
		PH	1693..1812	CDD:278594	16/118 (14%)
Fgd3	NP_056574.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		17/90 (19%)
		RhoGEF	156..335	CDD:238091	50/203 (25%)
		PH-like	367..474	CDD:418428	30/195 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535		9/53 (17%)
		FYVE_FGD3	527..580	CDD:277279	6/52 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..612		7/25 (28%)
		PH2_FGD1-4	606..710	CDD:270056	19/87 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910