DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Psd2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_006254639.1	Gene:	Psd2 / 307500	RGDID:	1311075	Length:	772	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	175/919 - (19%)
Similarity:	303/919 - (32%)	Gaps:	340/919 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 QMDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRK 382
            ::..||.|.||......|        ...:|.|.:|   |...:...:||      ||:
  Rat     5 KLPSDLHKEEGAIQDHSL--------EPEEGPGVQN---GTAASESLNSH------VIS------ 46

  Fly   383 TKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMG 447
                 .::..|.||:       .|..||.:|::.....:....|              |:|:|..
  Rat    47 -----PVSEKTGTLE-------GTMEPVGNPDVALPGLSLSLTN--------------GLALGQD 85

  Fly   448 GGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSDNVMF 512
            |      :|:.::    ..|:..|.||.....:     .||:|.|:.|
  Rat    86 G------NILEDS----VESRPWRASGPAEEED-----TPRSLCLDAE----------------- 118

  Fly   513 DNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSR 577
            |.|.....|    |..|....:                                      |.|..
  Rat   119 DTQLGLDCP----GEPDVRDGF--------------------------------------SATFE 141

  Fly   578 LLLEYEMHLRNTLAKGMDA--------ESYSLHTFEALLSQSMENLEFAESLP------------ 622
            .:||.|: ||.|....:|:        ||.|..:|||.|:..::  :.|...|
  Rat   142 KILESEL-LRGTQYSSLDSLDVLSLTDESDSCVSFEAPLTPLIQ--QRARDSPEPAGLGIGDIGP 203

  Fly   623 --------GSNQRSPYPLRRPNAKSSTLPLPPHRPLSTI-------------RDKERDRDRDGYY 666
                    |.:.....||||..:.|.:..:..|..|:::             .|.|.|.|.|
  Rat   204 EGDLGAAGGGDGELGSPLRRSISSSRSENVLSHLSLTSMPNGFHEDEPGGSGGDDEDDEDTD--- 265

  Fly   667 SDRNELIRERERERDRGYLSDHNSSFSNSR----------CASC--IGESAR--AQWFRHSDGWR 717
                :::........:..|||.:|..|:|.          ...|  :.|:||  |:...|.:|::
  Rat   266 ----KVLNSASDTSLKDGLSDSDSELSSSEGLEPGSTDPMANGCQGVSEAARRLARRLYHLEGFQ 326

  Fly   718 --SGSSTIGSGSGHGMMTQQIPGSGHKRSPWD---------------SLPSLRQ----------- 754
              ..:..:|..:....:.     :|...|.:|               :.|.:.:
  Rat   327 RCDVARQLGKNNEFSRLV-----AGEYLSFFDFSGLTLDRALRTFLKAFPLMGETQERERVLTHF 386

  Fly   755 ---------DSSLNDSGYKS----------------------------ARADSLEQRAEFIRQDS 782
                     |.|.::.|..:                            |..|.|....:|.: |.
  Rat   387 SRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHVNIGKKMSCQQFIANLDQLNDGQDFAK-DL 450

  Fly   783 LRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAK 847
            |::.|.|.:..:.    :.:|:..:.|.   :.||:.||...:.|..|:...||    .:|:...
  Rat   451 LKTLYNSIKNEKL----EWAIDEDELRK---SLSELVDDKFGTGTKKVTRILDG----GNPFLDV 504

  Fly   848 ATGTAASSFNCTGAVRKAGFLSVKKWLLRKKH-QIELAR----KRGWKGYWVCLKGTTLLFYPCD 907
            ....:|:::       |.|.|:      ||.| .::..|    :||||.::..||||.|.....:
  Rat   505 PQALSATTY-------KHGVLT------RKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDE 556

  Fly   908 SREGRSV-EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENW------ 965
            .|..::: |...|:.|.|..|:.....::.|:..:..|.||....:|||||.:.|:.:|
  Rat   557 YRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINL 621

  Fly   966 VNSIHSA--------------------CAAAFAR------HRGKTG--TLHLLQEEIFRLEKAIE 1002
            |.:|.||                    |...|.:      |..|..  |..|.:.....||:.::
  Rat   622 VAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRFCQEEQLRSHENKLRQVTAELAEHRCHPLERGLK 686

  Fly  1003 SDHKLKHMAELQQSVVTDQETR-----HQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPN 1062
            |....::  .|::..:|.:::|     |.:..:|....::|||:...       :|:|: ||  :
  Rat   687 SKEAEEY--RLKEHYLTFEKSRYETYIHLLAVKIKVGSDDLERIEAR-------LATLE-GE--D 739

  Fly  1063 PKSLLTHVS 1071
            |....||.|
  Rat   740 PALRKTHSS 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	41/162 (25%)
		PH	873..974	CDD:278594	34/132 (26%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Psd2	XP_006254639.1	Sec7	295..463	CDD:238100	23/173 (13%)
Psd2	XP_006254639.1	PH_EFA6	509..632	CDD:270107	38/135 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910