DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Arhgef37

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001094444.2	Gene:	Arhgef37 / 307398	RGDID:	1560471	Length:	676	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	166/786 - (21%)
Similarity:	277/786 - (35%)	Gaps:	222/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1436 TSSVSTTALTPSRQLTDAE-----KLRKVVMELVDTERTYVKHL----NNLLEHYLEPMKRETFL 1491
            |...|:.:.:|.::...:|     ..|..:.||:|||.:|:..|    :::..|..:       |
  Rat     6 TDEASSKSESPEQEGQGSEDKSLLHQRLAIRELIDTEVSYLHTLRLCTSDIRGHLQQ-------L 63

  Fly  1492 SNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF-K 1555
            ...:::.||.||.:|:....:||..|:|:...|   .|..|         .||:.||.:.... :
  Rat    64 PPGDLDILFSNIDDIIQVSSRFLHGLQETACKE---EKQAH---------LIGNLFLEFQEELEQ 116

  Fly  1556 LYSSFCASHSKAQKVLHPNEGNHALQE----FLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQ 1616
            :|..:||::.:|..::...:....||:    .:.|..| |...|.|...|:.|:|||.|||||||
  Rat   117 VYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAVP-QAGPSGLSFLLVIPLQRITKYPLLLQ 180

  Fly  1617 QMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGD 1681
            ::...|...|..|..|..|...::.|..:||| .::.:|..
  Rat   181 KILENTPADASAHPVLQRATSALQDVNSNINE-YKMRKEVA------------------------ 220

  Fly  1682 LLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEII 1746
             |.|..||.|::.:.|.:|    ..|.:                          ||..|...:::
  Rat   221 -LKYTKVEQLSLRERLARI----NTHTL--------------------------SKKTTRLSQLL 254

  Fly  1747 RYQV-LIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTA--DFRNAFLKTIR 1808
            :.:. |:|.||    .....|::..|.|..:.: ::|:         ||..|  |...|||
  Rat   255 KQEAGLVPRTE----DKEFDDLEERFQWVSLCV-TELK---------SNVAAYMDNLEAFL---- 301

  Fly  1809 QIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKK 1873
             ..|...||:.||            |.:::...|:......|...:.||::|.:.........:.
  Rat   302 -CFRPHERNLDIP------------GGAAEQYCSLARDLQLQAFLQFKQRLTGLVWQPLCSLARA 353

  Fly  1874 KSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHY---ASGHTHGQQMQPAGFRGRSKTVGDVTE 1935
            ..|.|......:  |.|...:..::....||.|.|   |:.||: |.:       .|..|.::.:
  Rat   354 LVGPQNLIKKRL--DKLLDFERVEEKLLDVGSVTYEEEAARHTY-QAL-------NSLIVAELPQ 408

  Fly  1936 ITCSSPEPHQQQQ-----------QQQQQQQQLMQQGHAHAHPHPHPHPREPP------------ 1977
            ..      |...|           .|:....|::::..:.....||.|..||.
  Rat   409 FN------HLVMQWLGQILRTFVVLQRDLADQVLRRAESSMALLPHRHVSEPDFQKLLEDTLGQS 467

  Fly  1978 ---------------PPPIRQPHL----HHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGR-- 2021
                           ||...||.|    |...|.:.|..|| |......:..||.....||.|
  Rat   468 SSQLRHFRESFEKVLPPSTSQPLLPGSEHQMQSLLTRYGPG-KIYQVTSNINGTGTLDLTLPRGQ 531

  Fly  2022 ----TPNHLTLSTTSTLSVGSTGSQ----ARLIQSSHP--PASYQP----VLMKDLGKPSPDESE 2072
                ..|..|....|...|.:.|.:    |..:|..||  |:..:|    .:.:|...|:|:.::
  Rat   532 IVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHPINPSEKEPRRQTGMPEDYWLPTPEPTQ 596

  Fly  2073 LESESEVHAAQVAASF--------NLSLGSSGSLFASDARD------------NQTQSRTQSQIH 2117
            ....:....:||.|.:        .|||.:...:...:|:|            |..:....|...
  Rat   597 PSVPTVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNFL 661

  Fly  2118 SLHPSP 2123
            :..|||
  Rat   662 ARTPSP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	55/199 (28%)
		PH2_Tiam1_2	1650..1823	CDD:269957	32/175 (18%)
		PH	1693..1812	CDD:278594	21/121 (17%)
Arhgef37	NP_001094444.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/19 (21%)
		RhoGEF	34..211	CDD:395496	54/196 (28%)
		BAR_DNMBP	264..452	CDD:153273	45/234 (19%)
		SH3_ARHGEF37_C1	510..563	CDD:212733	11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601		7/32 (22%)
		SH3_ARHGEF37_C2	607..663	CDD:212874	10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..676		4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810