DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Psd3

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_038950877.1	Gene:	Psd3 / 306380	RGDID:	1559968	Length:	1297	Species:	Rattus norvegicus

Alignment Length:	1051	Identity:	221/1051 - (21%)
Similarity:	356/1051 - (33%)	Gaps:	354/1051 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PPGKGKVKAKRKPLSTPASPSRVR-----QEPQCTCMSAEQYARLR--TDPRVRG-----SSTLP 212
            |.|.|  |:..:|||... |:..:     ||.....:..|..|:|.  |:.|.:|     .|..|
  Rat   435 PVGPG--KSPDRPLSVEV-PTEEKFSLHIQEDLTALLPEETPAQLSQITNYRRQGPLHVPESACP 496

  Fly   213 RNVGS---HRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQD 274
            .::||   |...|     ::|           :|.|..:..|....:|.|      :||...||
  Rat   497 VSLGSAKNHNSVD-----RIG-----------ALKDQKSDLGRENPRGCD------RGGSMGRQ- 538

  Fly   275 VANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQ--AGGGLHQ 337
                   |....|...||..:.:        |.:|.:..||..:...:.:.|...:  |.|..|.
  Rat   539 -------TRIKHVEFQGVEILWT--------GEEVESRHPAGFETPPERTASPVRKEFAKGPSHS 588

  Fly   338 S--VGTCTSSSKGTGTRNK-----------------------DFGDD--MTRDAHSHDMHQHNVI 375
            |  .|.|:||:..||:.:.                       :.|:|  ..|::..| :.::..|
  Rat   589 SSATGACSSSTHLTGSVSDETCKEPSARPGTSLGTLSPVPLGESGEDDVFLRESKEH-LEENFDI 652

  Fly   376 NNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTES-PVTSPEMGRRRYN---YYNANAAQTLGHPPH 436
            ..:..|..|..|.:......:   |.|..:.:| .|.|.:......|   ||:|.:.:||...|.
  Rat   653 QGDKERFFKQEEHLRGGDDDI---LGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPD 714

  Fly   437 MH-----------------------------QH---------GMAMGMGGGGGGGHHIMNNNTMG 463
            .:                             .|         |:.||...|...|.|..:|:...
  Rat   715 SYFSFEMPLTPMIQQRIKEGGQFLERTSVGGHHDVLSVSADGGIVMGYSTGITNGLHDPSNSVYT 779

  Fly   464 RASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEG-SPPSDNVMFDNQCYATTPSSSNG- 526
            | ..|...|.|| |.:...:|.|.|            ::| |......:.:.:   ||.:.|||
  Rat   780 R-GPQEIAFWGS-SGYCFDKGKPTR------------LDGNSEMGSTEILEKE---TTENLSNGT 827

  Fly   527 NSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHL-RNTL 590
            ||:.:.:                  :|.::..:|..:...             .:...|| :|..
  Rat   828 NSNVEAA------------------KRLAKRLYHLDRFKR-------------SDVAKHLGKNNE 861

  Fly   591 AKGMDAESYSLHTFE---ALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLST 652
            ...:.||.| |..|:   ..|.||:.....|.||.|..|
  Rat   862 FSKLVAEEY-LKFFDFTGMTLDQSLRYFLKAFSLVGETQ-------------------------- 899

  Fly   653 IRDKERDRDRDGYYSDRNELIRERERERDRGYLS---DHNSSFSNSRCASCIGESARAQWFRHSD 714
                ||:|... ::|:|              |.|   |..:|.....|.:|      |....::|
  Rat   900 ----ERERILI-HFSNR--------------YFSCNPDTITSKDGVHCLTC------ALMLLNTD 939

  Fly   715 GWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIR 779
                         .||.:     ..|.|.:..:.:.:|:   .:|:.|..|  .|.|:.....|:
  Rat   940 -------------LHGHV-----NIGKKMTCQEFITNLQ---GVNEGGDFS--KDLLKALYNSIK 981

  Fly   780 QDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPY 844
            .:.|  |:.:|.|.:    :::..|.||.:........||   |:..||        ...:..|:
  Rat   982 NEKL--EWAADDEEK----KKSPSEGTDEKANGTHPKTIS---RIGSTT--------NPFLDIPH 1029

  Fly   845 KAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELAR-----KRGWKGYWVCLKGTTLLFY 904
            ...|            ||.|:|||:      ||.|.....:     |||||.::..||||.|...
  Rat  1030 DPNA------------AVYKSGFLA------RKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQ 1076

  Fly   905 PCDSREGRSV-EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNS 968
            ..:.:..:|: :...|:.:.|..|:.....|:.|:..:|.|.||.....|||.....|::.|:|.
  Rat  1077 KDEYKPEKSLSDEDLKNAVSVHHALASKATEYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINK 1141

  Fly   969 IHSACAAA----------------FARHRGKTGTLHLLQEEIFRLEKAIESDHKLK----HMAEL 1013
            |:  |.||                |:|......|..|.|||..   |:.||  |||    .:||
  Rat  1142 IN--CVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQL---KSHES--KLKQITTELAE- 1198

  Fly  1014 QQSVVTDQETR------HQIQTQILQWEENLERLHCEQFRLRCYMASLQSG-------ELPNPKS 1065
            .:|...|::.:      ::::...|.:|:.         |...|::.|:.|       |...|..
  Rat  1199 HRSYPPDKKVKAKDVDEYKLKDHYLDFEKT---------RYEIYVSILKEGGKDLLSTEGNEPVG 1254

  Fly  1066 LLTHVSRPTKN 1076
            |....|.|:.|
  Rat  1255 LKKSHSSPSLN 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	41/146 (28%)
		PH	873..974	CDD:278594	30/106 (28%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Psd3	XP_038950877.1	Sec7	830..985	CDD:238100	42/260 (16%)
Psd3	XP_038950877.1	PH_EFA6	1030..1155	CDD:270107	40/144 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910