DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Spata13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001178615.1 Gene:Spata13 / 305938 RGDID:1307364 Length:1247 Species:Rattus norvegicus


Alignment Length:1843 Identity:335/1843 - (18%)
Similarity:531/1843 - (28%) Gaps:748/1843 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 GKGKVKAKRKPLSTPASPSRVR----QEPQCTCMSAEQYA-RLRTDP------------RVRGSS 209
            |.|:........|.|.:|..|.    |...|...|::..| ..|..|            |:..:|
  Rat     7 GHGQGATATCSASNPKAPKMVTSSACQNGGCKSSSSDPEAGEARLSPSKLVRLFSGSRKRMNSNS 71

  Fly   210 TLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQD 274
            ..||:|                  ||  |.::|.::.:||.            |:|         
  Rat    72 ERPRSV------------------VV--VGNSSTWNALASF------------RKM--------- 95

  Fly   275 VANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQA--GGGLHQ 337
                |........::.|:         ||..|::|..::.:.   |...:...||.|  |.||  
  Rat    96 ----GSFKRLKSSVLQGI---------QNREGAEVSKEESSG---DQGRAAPNGTIAILGKGL-- 142

  Fly   338 SVGTCTS---SSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRM 399
              |.|.|   ...|.|:...|..|  |.||.....|:...|.........|..|       |.|.
  Rat   143 --GRCASLGPVGDGAGSDCSDPED--TEDAFQRSTHRSRSIRRAYGLGRISLLD-------LGRQ 196

  Fly   400 LKPMPST-ESPVTSPEMGR-----RRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMN 458
            ..|.|:. |..|..||..|     ||     :.:..:|.                       ::.
  Rat   197 SVPEPAVCEIQVRDPEPSRAVPLPRR-----SKSIDSLS-----------------------VLK 233

  Fly   459 NNTMGRASSQSSRFSGSRSSHEIGRGYPPRNL---YLELER----ERSCIEGSPPSDNVMFDN-- 514
            ::...:::|..:...|.|.       .|.|.|   :.:.|:    ||.......|.....||.  
  Rat   234 SSFKRKSASNLTELQGDRQ-------VPSRTLSSFFTDSEKPGGSERRTRRWRSPIRAKDFDRVL 291

  Fly   515 ----------------QCYATTPSSSNGN--------SDQDQSYGQQQSSGQHPQQQQGPPQRSS 555
                            :..|.:|.|..|:        |.....|.::.||...|..::|.|..|.
  Rat   292 KLVSNVKEAAWKRETPRSAAPSPGSGLGDANPLLAPRSKLHDDYSRRTSSSVEPDARRGGPLSSP 356

  Fly   556 RHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEAL-LSQSMENLEFAE 619
            ........||...|.|.......:...|......|  |.|..    ||..:. :....|.|..|.
  Rat   357 CASAPCTAAPYTAPEPHLDVDTAVFPLESKSAQPL--GTDGP----HTSSSSPIPTDTEGLSQAS 415

  Fly   620 SLPGSNQRSPY-PLRRPNAKSSTLPLP--PHRPLST------------IRDKERDRDRDGYYSDR 669
            |...:..:.|: |::.|.....|.|.|  |..|.||            ..|.| :|..|..:...
  Rat   416 SEAHTGSQHPFDPVQLPTPLRPTTPKPQSPQSPGSTKCPSSLSVLSLSSADSE-ERSEDAVHRQA 479

  Fly   670 NELIRERERERDRGYLSDHN--SSF-SNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGM 731
            ..:..:.......|.:...|  ||| ||...|:...|..........|.||.||:.....:....
  Rat   480 GPMSLQDAVPAAAGDVGGENSESSFPSNPDGATSPEERKEEVRVVTEDDWRQGSALEEEQNEAPR 544

  Fly   732 MTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYG 796
            ::::..|||.:..|          ..|:|.|..::|:.|       |.:|::.::  ...|.|..
  Rat   545 ISRRKWGSGRRTGP----------RPLSDYGQLASRSLS-------IPEDAIATD--PPGEDRVD 590

  Fly   797 IVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGA 861
            .:..||:.:|....|  |||                                        .|...
  Rat   591 RMHPASVTTTSQDPC--TSS----------------------------------------GCPRG 613

  Fly   862 VRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDG 926
            .|:...:||                         :.|.:  ||  .:.:...||.     ::|..
  Rat   614 GRRRRPISV-------------------------IGGVS--FY--GNTQAEDVEN-----LLVQP 644

  Fly   927 AIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQ 991
            |...|:|.|....|                                                   
  Rat   645 AARPPVPAHQVPPY--------------------------------------------------- 658

  Fly   992 EEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQ 1056
                   ||:.:                                           |||.:.    
  Rat   659 -------KAVSA-------------------------------------------RLRPFT---- 669

  Fly  1057 SGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRS 1121
                         .|:.|...|:::|                                       
  Rat   670 -------------FSQSTPIGLDRVG--------------------------------------- 682

  Fly  1122 NSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKK 1186
                .||.|         ||..|:....|.|:..:.|..|.|:|......:.|            
  Rat   683 ----RRRQM---------KTSNVSSDGGAESSALVDDNGSEEDFSYEELCQAN------------ 722

  Fly  1187 RRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQD 1251
                  ..|..|....|..|.|.:...| ||.:.|:.   ..|..:|..||..            
  Rat   723 ------PRYLQPGGEQLAINELISDGSV-VCAEALWD---HVTMDDQELGFKA------------ 765

  Fly  1252 ELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPD 1316
                                  ||.|.|:.   .|:.|.                          
  Rat   766 ----------------------GDVIQVLE---ASNKDW-------------------------- 779

  Fly  1317 LVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDP 1381
                                                     |.|.::|     .|:....|||  
  Rat   780 -----------------------------------------WWGRNED-----KEAWFPASFV-- 796

  Fly  1382 AAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRK--SSPTGSVTSSVSTTAL 1444
                                                .|:..::|..:  ||..|           
  Rat   797 ------------------------------------RLRVNQEELPEPCSSSQG----------- 814

  Fly  1445 TPSRQLTDAEKLR------------KVVMELVDTERTYVKHLNNLLEHYLEPMKRET-FLSNAEI 1496
              ..|..||.|.|            .|:.|:::|||.|:|||.::.|.|:...::.| ..:..::
  Rat   815 --EEQDEDASKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTVGQL 877

  Fly  1497 NALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFE-HCGQFRNVLFAIGSAFLYYVNHFKLYSSF 1560
            ..:||||.:|..|||:||:      |||..:||.| |       |..|||.||.:...|.:||.:
  Rat   878 ATIFGNIEDIYKFQRKFLK------DLEKQYNKEEPH-------LSEIGSCFLQHQEGFAIYSEY 929

  Fly  1561 CASHSKA----QKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNL 1621
            |.:|..|    ..::..::..|.   |.|.|..:|.....|:.:|:.|:|:|.||||.|.::...
  Rat   930 CNNHPGACVELSNLMKQSKYRHF---FEACRLLQQMIDIALDGFLLTPVQKICKYPLQLAELLKY 991

  Fly  1622 TDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYG 1686
            |.....::.::..|.:.|:.||..|||.:|..|.    .|.:.|...            .::.:.
  Rat   992 TTQEHSDYNNIKAAYEAMKNVACLINERKRKLES----IDKIARWQV------------SIVGWE 1040

  Fly  1687 GVEWLNISDFL---GKIKK----GLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVE 1744
            |::.|:.|..|   |::.|    |.....:.|:|...:|...|:.||:                :
  Rat  1041 GLDILDRSSELIHSGELTKITRQGKTQQRVFFLFDHQLVSCKKDLLRR----------------D 1089

  Fly  1745 IIRYQVLIPVTEVQ-VRASSAKDMDSHFLWELIHLRSQ---LQRRSEKVYVL----SNSTADFRN 1801
            ::.|:..:.:.||. |.....:|.|    |.| .:|:.   :.:.:::|::.    ....|.:..
  Rat  1090 MLYYKGRMDMDEVDIVDVEDGRDKD----WNL-SMRNAFKLVSKATDEVHLFCARKQEDKARWLQ 1149

  Fly  1802 AFLKTIRQIIRESVRNMSIP--MKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHG 1864
            |:....|::..:....|.|.  .|.....:...:||..    |.||  ||..:..|.|.:..:|.
  Rat  1150 AYADERRRVQEDQQMGMEISENQKKLAMLNAQKAGHGK----SKGY--NSCPVAPPHQSLPPLHQ 1208

  Fly  1865 SH-------------TLGKPKKK 1874
            .|             .|.:||:|
  Rat  1209 RHITVPTSIPQQQVFALAEPKRK 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 14/124 (11%)
PH 873..974 CDD:278594 11/100 (11%)
TIAM1_RBD 1141..1219 CDD:176413 17/77 (22%)
PDZ_signaling 1221..1308 CDD:238492 11/86 (13%)
RhoGEF 1456..1647 CDD:238091 62/208 (30%)
PH2_Tiam1_2 1650..1823 CDD:269957 32/189 (17%)
PH 1693..1812 CDD:278594 24/133 (18%)
Spata13NP_001178615.1 SH3_ASEF 729..800 CDD:212906 25/221 (11%)
RhoGEF 839..1018 CDD:279015 62/194 (32%)
PH_Collybistin_ASEF 1023..1161 CDD:269931 29/174 (17%)
PH 1051..1150 CDD:278594 21/119 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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