DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Arhgef4

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_008765203.2 Gene:Arhgef4 / 301334 RGDID:1586179 Length:1751 Species:Rattus norvegicus


Alignment Length:1894 Identity:342/1894 - (18%)
Similarity:552/1894 - (29%) Gaps:730/1894 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 PIDAKQFRECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQEPQCTCMSAE 194
            |.|....::|   :...|.||.|...   ..|.||.:|.:|||      |.|....||..|    
  Rat   445 PDDVIGKQKC---ALNISAKAGSQTE---SSPSKGALKEERKP------PDRASSFPQGCC---- 493

  Fly   195 QYARLRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGAD 259
                                         .||..|.:.::|.:...|.     .:..|.|     
  Rat   494 -----------------------------TGQVPVCNKRLVGSWEETE-----RACAPET----- 519

  Fly   260 TLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLS 324
                .:|....|..:.|..||..:     |.|.||                     |.|..:|..
  Rat   520 ----ALKARVIDSSEAAEEGVVLD-----VQGRGN---------------------ALQSRLDFP 554

  Fly   325 KSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDF--GDDMTRDAHSHDMHQHNVINNNTRRKTKSTE 387
            ..|.|....|        :..::|.|.....|  |...||.||....|....|....|::.:.|.
  Rat   555 TVEVTYCNPG--------SECAQGPGDDLDPFTSGQPQTRKAHGASRHSCKFIMIAVRQEGRQTS 611

  Fly   388 DMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNA-------NAAQTLGHPPHMHQHGMAMG 445
            ..... ..|:......|..:.      .|...|.:..|       |..:..|.|           
  Rat   612 TRKAH-CLLESQCGGFPEEKG------TGSTAYGFPRASEMPLCGNECELPGCP----------- 658

  Fly   446 MGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSDNV 510
             |...|||                                .|:.|...:|..|..:..:...|.|
  Rat   659 -GAEPGGG--------------------------------APQLLARGIEGVRVPVSRTASDDTV 690

  Fly   511 MFDNQCYATTPSSSNGNSDQDQSYGQQQSSG---QHPQQQQGPPQ-------RSSRHQHHHQ--- 562
                         |:.:|.:|...|::.|.|   .|.:|.|..|.       |.:....|.:   
  Rat   691 -------------SSDDSLEDALLGKRLSGGCECVHTEQNQELPSSERKQGGRGTEDTEHAEISR 742

  Fly   563 -QAPNVT----------------PTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQ 610
             ||..|.                |:|.|.|.:.|...|..:|..||.   |.....:.|||.:.:
  Rat   743 AQAGEVEVPLSGVGTPGDLSSEGPSPDSCTVKRLKTTESRIRARLAL---AHKTFTNFFEAKVIE 804

  Fly   611 SMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRE 675
                    ::.|||.:                           .:||:.|...|.:         
  Rat   805 --------KTSPGSVK---------------------------GEKEKHRRTQGSW--------- 825

  Fly   676 RERERDRGYLSDHN---------------SSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGS 725
                  |.:|.:.|               ..|....|:|  ..:.|.    |.:.|     |:|.
  Rat   826 ------RAFLRNKNVEGSKRPSLVSGVPGPDFPQLLCSS--PPATRG----HCEEW-----TVGI 873

  Fly   726 GSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSD 790
             ..|..        |...:|.:|..:|           .|:|..|.|.|                
  Rat   874 -DNHVF--------GESWTPLNSPATL-----------SSSRLVSPEHR---------------- 902

  Fly   791 RESRYGIVQQASIESTD-------SRMCYLTS------SEISDDDRMSLTTAVSDEDDGESVMAS 842
            |:|...|...|:.||:.       .:..:|||      ::|.....:..::|.....:.:.:...
  Rat   903 RKSEPTIKHTATPESSTHLSSGVFPKPSWLTSATSPGAAQIDISYTLPCSSACHLSYESQGMPCR 967

  Fly   843 PYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCD 907
            |...|.....|      ||.|                 ::|           ||.|.|.......
  Rat   968 PTSPKPRSPMA------GAQR-----------------VDL-----------CLAGRTSAVSMVS 998

  Fly   908 SREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSA 972
            .|..|            |......:||.||      .|.|.....|   ..|...:|......|.
  Rat   999 LRSDR------------DANRCSEVPERPK------ASKARASLLL---SLQTLNQNDQKEDRST 1042

  Fly   973 CAAAFARHRGKTGTLHLLQE-------EIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQ 1030
            |..    |.| .||:..|::       :....|:.:...|.....||..|..|:..|        
  Rat  1043 CQC----HHG-LGTVPFLRDLPGNESTQESPPEEKLGCSHDHNTGAEPTQRPVSAAE-------- 1094

  Fly  1031 ILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVS-------RPTKNTLNK-------- 1080
            ::.|  .|..:..||....   |.||....|.    .:|||       :..:..|.|        
  Rat  1095 VVTW--TLPSISAEQVPRE---APLQFRRAPQ----RSHVSFDDLWIEKTQRRKLEKQMLLRRQM 1150

  Fly  1081 -LGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKV 1144
             .|:.:|....   |.|..::         .:...|.:..||:..|....|.::....||.....
  Rat  1151 STGLASVDPVQ---CWRKTTV---------TSPESPHLPRRSHLLSQSAPMGLDHTGWPEPMPNT 1203

  Fly  1145 AMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMED--HNYFVPHRNDLIENY 1207
            .|||.....|...:..|.|:..                     .|:..  |:|..|.        
  Rat  1204 GMPDGTLDAVCAEETGSEEDLY---------------------EDLHSSGHHYSHPR-------- 1239

  Fly  1208 LHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGII 1272
                                                                             
  Rat  1240 ----------------------------------------------------------------- 1239

  Fly  1273 KGDEIMVINGAIVSDLDMMYLES----VLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVC 1333
            .|.|.:.|| .::||...:..|:    |..::|.|..       :..|::.:|..|         
  Rat  1240 GGGEQLAIN-ELISDGSAVCAEALWDHVTMDDQELGF-------KAGDVIEVMDAT--------- 1287

  Fly  1334 PPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEA-------ESSPATSFVDPAAMAAQLAVG 1391
                      :.|...|.:|...||        .|.:       :..||..:..|.|.|.:....
  Rat  1288 ----------NREWWWGRVVDGEGW--------FPASFVRLRVNQDEPADDYEAPRAGAGEADDS 1334

  Fly  1392 GVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKL 1456
            |                                                     |..|....:..
  Rat  1335 G-----------------------------------------------------PEAQSCKDQMR 1346

  Fly  1457 RKVVMELVDTERTYVKHLNNLLEHYL-EPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEES 1520
            ..|:.|::.|||.|:|||.::.|.|: :..|||...|..::..:||||.:|...|:.|::.||:.
  Rat  1347 TNVINEILSTERDYIKHLRDICEGYVRQCRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQK 1411

  Fly  1521 LDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASH----------SKAQKVLHPNE 1575
            .:.|            |..|..:|:.||.:...|::||.:|.:|          :|..|.::..|
  Rat  1412 FNTE------------RPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFE 1464

  Fly  1576 GNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGME 1640
            ....||..:         ..:|:.:|:.|:|:|.||||.|.::...|..:..:..::..||..|:
  Rat  1465 ACRLLQRMI---------DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKNVEAALHAMK 1520

  Fly  1641 KVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFL--GKIKKG 1703
            .||:.|||.:|..|....|     .|.|.|.:   |....|||       :..|:.:  |::.:.
  Rat  1521 NVAQLINERKRRLENIDKI-----AQWQSSIE---DWEGEDLL-------VRSSELIHSGELTRV 1570

  Fly  1704 LELHA-----MCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQ-VRAS 1762
            .:..|     |.|:|...:::..|:.||:                :::.|:..:.:.::: |...
  Rat  1571 TQPQARSQQRMFFLFDRQLIYCKKDLLRR----------------DVLYYKGRLDMDDLEVVDVE 1619

  Fly  1763 SAKDMDSHFLWELIHLRSQLQ---RRSEKVYVLSNSTADFRNAFLKTIRQIIRESVR---NMSIP 1821
            ..||.|.|     :.:::..:   ..:...::|.....:.:..:||...: .||.||   .....
  Rat  1620 DGKDRDLH-----VSVKNAFRLYCGTTGDSHLLCARKPEQKQRWLKAFAR-EREQVRLDQETGFS 1678

  Fly  1822 MKNFGGSSGSVSGHSSQGMG---SMGYPG-------NSQTLERPKQQITIVHGSHTLGKPKKKSG 1876
            :.........::....|..|   ::|.||       .|....||:||:.:      |.:|::|..
  Rat  1679 ITELQRKQAMLNASKQQATGKPKAVGRPGYLTRHKHPSLPASRPQQQVLV------LAEPRRKPS 1737

  Fly  1877 SQRHSAGNI 1885
            :..||...:
  Rat  1738 NFWHSISRL 1746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674 3/13 (23%)
PH1_Tiam1_2 860..985 CDD:269937 24/124 (19%)
PH 873..974 CDD:278594 18/100 (18%)
TIAM1_RBD 1141..1219 CDD:176413 10/79 (13%)
PDZ_signaling 1221..1308 CDD:238492 10/90 (11%)
RhoGEF 1456..1647 CDD:238091 56/201 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 32/186 (17%)
PH 1693..1812 CDD:278594 18/129 (14%)
Arhgef4XP_008765203.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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