Protein Alignment sif and Arhgef38

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_017446839.2
• Gene: Arhgef38 / 295449
• RGDID: 1311728
• Length: 770
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 130/617 - (21%)
• Similarity: 236/617 - (38%)
• Gaps: 183/617 - (29%)

  Fly  1444 LTPSRQLTDAE---------------KLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSN 1493
            :||..:.:.||               |..|::.||:.|||.|:..|...:...::|: |...:..
  Rat    68 MTPQAECSSAETPTPEEEQQVGRMMAKRAKIIRELIQTERDYLTDLELCVREVVQPL-RSKQIDR 131

  Fly  1494 AEINALFGNIHEIVTFQRQFLQNLEE-SLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-L 1556
            .::.:||.||..:.....:.|..||| :.|:||             .:..||..||......: :
  Rat   132 LDVESLFSNIESVHQISAKLLSLLEEATTDVEP-------------AVQVIGEVFLQIKGPLEDV 183

  Fly  1557 YSSFCASHSKAQKVLHPNEGNHALQEFL-----AARNPKQQHSS----TLESYLIKPIQRILKYP 1612
            |..:|..|.:|..||...|....|::.|     :.:....|...    .:.|.:||||||::|||
  Rat   184 YKIYCYHHDEAHSVLESYEKEEDLKQHLSHCIQSLKTIYMQEGKPNLLDMGSLMIKPIQRVMKYP 248

  Fly  1613 LLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR---------IHEEYGAIFDHLFRQH- 1667
            |||.::||.|.....::..|.||...::.:..:|||::|         .:||..::.|.|.|.:
  Rat   249 LLLCELRNSTPPSHPDYRALEEAFAAVKDINVNINELKRRKDLVLKYKKNEEEESLKDKLSRLNI 313

  Fly  1668 ---QKSCKQPID----LSPGDLLY----YGGVEWL-------------NISDFLGKIKKGL--EL 1706
               .|..|:..:    |:.||...    :...|.|             |||..|..|::.:  .|
  Rat   314 HSISKKSKRVTNHLKILTRGDSQVKDNTFNREEKLFRSLEKTVRLCVKNISSCLQHIEEAVPFTL 378

  Fly  1707 H---AMC------------------------FVFKSAVVFLC-----------KERLRQKK--KL 1731
            |   |:|                        |..:|..:.|.           .::|.||:  ||
  Rat   379 HSVAALCEISYKDGEKNCMEPQSQASNPCHDFAARSQRLILSPLSTLLSLFPGPQKLIQKRYDKL 443

  Fly  1732 MGVSS---KNATNEVEIIR--YQVLIP--VTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKV 1789
            :..:|   ::||.|.::.:  |:.|..  |.|:|....:|:.:..:.|...:.|...|...:.:.
  Rat   444 LDCNSSLPRSATTESDLAKREYEALNAQLVEELQAFNQAARKILLNCLLSFVTLLRDLMLVALQA 508

  Fly  1790 YVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGY-PGNSQTL- 1852
            |              .|::          ::|:...|.|  .:.....:.:.|:.: ..||.|.
  Rat   509 Y--------------STVK----------TVPLPVLGIS--EIQNQVLEEVHSLNFVKDNSATFI 547

  Fly  1853 --------ERPKQQI------TIVH--------GSHTLGKPKKK-SGSQRHSAGNIDYDNLSGSQ 1894
                    ::|.|.:      |.||        |:..|.:.|:| :.:|.|....::.:.::..:
  Rat   548 ERKLSFEKKKPTQVLPEVPHQTDVHRSKLLSTYGAEELYRAKRKCNATQEHDVSLLEGELVAVLE 612

  Fly  1895 EADDLPPS------VGVVHYASGHTHGQQMQP 1920
            :.|.|..:      .|   :..|:.:...::|
  Rat   613 QKDPLGSTSRWFVDTG---FVKGYVYSSFLRP 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	54/201 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	46/255 (18%)
		PH	1693..1812	CDD:278594	31/167 (19%)
Arhgef38	XP_017446839.2	RhoGEF	98..283	CDD:395496	53/198 (27%)
		BAR	336..510	CDD:416402	33/187 (18%)
		SH3	585..641	CDD:418401	9/58 (16%)
		SH3_DNMBP_C2	710..766	CDD:213017

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910