DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Vav3

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_017446264.1	Gene:	Vav3 / 295378	RGDID:	1565941	Length:	875	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	122/579 - (21%)
Similarity:	229/579 - (39%)	Gaps:	166/579 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            |:|:|..|....||.     .:.:.:..|...||                ||..|.:.|.::.::
  Rat   174 EDLMKAEEAHQAKSQ-----ENDIRSCCLAEIRQ----------------TEEKYTETLESIEKY 217

  Fly  1481 YLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGS 1545
            ::.|:||  ||:.||.:::|.||.::|...|..:|.:.:|:..:.|.|.::
  Rat   218 FMAPLKR--FLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDHNLYQ-------------- 266

  Fly  1546 AFLYYVNHFKLYSSFCASHSKAQKVLH-----PNEGNHALQE-FLAARNPKQQHSSTLESYLIKP 1604
            .|:.|.....:|..:|:....|...|.     ..:....|:| ...|.|.|    .||...|:.|
  Rat   267 VFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVRLKLEECSKRANNGK----FTLRDLLVVP 327

  Fly  1605 IQRILKYPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQ 1668
            :||:|||.||||:: ::..|.....::.|  ||..|:.:|:::||::|.:|....|     :|.|
  Rat   328 MQRVLKYHLLLQELVKHTHDPMEKSNLKL--ALDAMKDLAQYVNEVKRDNETLREI-----KQFQ 385

  Fly  1669 KSCK---QPIDL---SPGDLLYYGGVEWLNISDFLGKIK-KGLELHAM----CFVFKSAVVFLCK 1722
            .|.:   ||:.|   ..||                |:|: ..|:.|..    .|:|..||: :||
  Rat   386 LSIENLNQPVLLFGRPQGD----------------GEIRITTLDKHTKQERHIFLFDLAVI-VCK 433

  Fly  1723 ER--LRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQ---- 1781
            .:  ..:.|:::.:......|.          |.|:.:.:..|       :.:.|||.:.|
  Rat   434 RKGDNYEMKEIIDLQQYKIANN----------PTTDKENKKWS-------YGFYLIHTQGQNGLE 481

  Fly  1782 -------LQRR--SEKVYVLSN-----STADFRNAFLKTIRQIIRESVRNMSIPMKNFGG----S 1828
                   |:::  .:....|||     :.::|.:..:.|..::....|..|.:....:.|    .
  Rat   482 FYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFK 546

  Fly  1829 SGSVSGHSSQGMGSMGYPGNSQTLE----RPKQQITIVHGSHTLGKPKKKSGSQRHSAGNID--- 1886
            .|: ..| .:.:|.:...|...::|    :|               |:|::...|.::..:|
  Rat   547 CGA-KAH-KECLGRVDNCGRVNSVEQGPFKP---------------PEKRTNGLRRASRQVDPGL 594

  Fly  1887 -----YDNLSGSQEADDLPPSV---GVVHYASGHT----HGQQMQPAGFRGRSKTVGDV 1933
                 ..|.:|:.     ||::   ..:|..:|.|    .| :.....::||:...|:|
  Rat   595 PKMRVIRNYTGTP-----PPALHEGPPLHIQAGDTVELLRG-EAHTVFWQGRNLASGEV 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	50/197 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	38/203 (19%)
		PH	1693..1812	CDD:278594	25/143 (17%)
Vav3	XP_017446264.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910