DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Akap13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_038961459.1 Gene:Akap13 / 293024 RGDID:727893 Length:2793 Species:Rattus norvegicus


Alignment Length:2663 Identity:502/2663 - (18%)
Similarity:815/2663 - (30%) Gaps:957/2663 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 DPMTNDTWGLNFTSPIDAKQFREC--CSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPAS 178
            |.:|:||...|      .|....|  |:...|...|     .|:.|.|....::      ..|..
  Rat   701 DTVTSDTAAHN------QKSVGSCHLCALDAKNQEK-----DLRQDTPSVNTLE------DVPHL 748

  Fly   179 PSRVRQEPQCTCMSAEQYARLRTDPRVRGSS-TLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTS 242
            ||.|.|       |.|:....:..|  |||| :|..:..|..:|..|....|.|.|.....:...
  Rat   749 PSVVPQ-------SEEKLEPDQVSP--RGSSFSLASSPESESVTKDDVLSLVSSQKEKGTATPQL 804

  Fly   243 LYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVI--VTGVGN---VGSDMCGQ 302
            ......|.||   .|.|.         .|...|.:...:..||..:  .|.:||   ||      
  Rat   805 HRAPACSDGP---DGRDL---------NDTDKVGDGAASPPTPSAVELQTSMGNTSPVG------ 851

  Fly   303 NHVGSQVGNDDPAACQMDMD-----------LSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDF 356
              ||.|.|:...|..::..|           :|.|...:.||.:     ....||...|...||.
  Rat   852 --VGEQEGSSLTATLEVLSDSLLQSVDKAALVSDSLLPEEGGSI-----VVPESSTALGQGGKDK 909

  Fly   357 G---DDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPM--------------- 403
            .   ..:..|.||.:|          .|:.:.|.....:.|.|..  |||               
  Rat   910 ATKCPSVKEDVHSSEM----------SREDQRTPPPGQEISRLCE--KPMSALCAGEKALQHSNS 962

  Fly   404 PSTES--------------PVTSPEMGRRRYNYYNANAAQTLGHP-----PHMHQHGMAMGMGGG 449
            |.|.|              |.:||.|        ...|.|.|..|     ....|...:....|.
  Rat   963 PDTPSACLQTETKHNKEVAPQSSPLM--------KGGAVQNLVPPKTSLSADSEQKTSSTEQSGS 1019

  Fly   450 ----GGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGR--------------------------- 483
                ||....:..:......|.:|.:|.|..|:.::.|                           
  Rat  1020 SLLPGGASEALRCSQPSLSVSVESIQFQGKTSACKVSRNAMEDVTVADAFLATAEPTKEDALHHV 1084

  Fly   484 ---------------GYP----------------PRNLYLELERERSCIEGS----PPSDNVMFD 513
                           |.|                |....|:.:||:  :||:    |.|.:....
  Rat  1085 KDISDLLNQEKKTTPGLPEALLDKGVTDLQEVITPEIEPLDCKREK--LEGTDLSCPTSKSKETP 1147

  Fly   514 NQCYATTP-----------SSSNGNSDQ-DQSYGQQQS-SGQH-----------PQQQQGPPQRS 554
            |....|.|           |:.|.|..| |..:..|.| .|:.           .|...|||...
  Rat  1148 NNEETTQPPARDLPTETGLSAINDNGPQADMKHVTQASVPGEESNVTTVLGMVSTQAADGPPGAD 1212

  Fly   555 SRHQHHHQQAPNVTPTPGSPTSRLLLE---YEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLE 616
            |..:                |:..::|   .::...|||...::.::..|.:.|.   :.:||..
  Rat  1213 SIEE----------------TATRIVEAVIKQIKASNTLRTQVEIQNPPLSSSEI---KEIENTG 1258

  Fly   617 FAES----LPGSNQRSPYPLRRPNAKSST-------------LPLPPHRPLSTIRDKERDRDRDG 664
             :||    |||.      ||:..|.:..|             :.|..|||               
  Rat  1259 -SESARVFLPGE------PLQMENTQKETTGHCSVETEAPEKIILAVHRP--------------- 1301

  Fly   665 YYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGH 729
                  |...|....:..|.:     ...:.|.|:                  |....||:|:..
  Rat  1302 ------EPAPEMPDTKTGGEV-----DLLSKRSAA------------------SEEEAIGNGAAT 1337

  Fly   730 GMMTQQIPGSG-HKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRES 793
            ..| :|.||:. ..|..|.::....:.:||      .|...|.|.|: || ...|.:|.    .:
  Rat  1338 PKM-KQAPGTQVINRESWCAIEPCPEAASL------LASKQSSECRS-FI-DVGLGTEC----AT 1389

  Fly   794 RYGIVQQASIESTD--------------------SRMCYLTSSEISDDDRMSLTTAVSDEDDGES 838
            :.|::|:.|...:|                    ..:|..|.|..|.||..||        |..|
  Rat  1390 KEGVLQRESGSDSDLFHSPSDEMDSIIFSKPEEEQLLCDTTGSSSSTDDTASL--------DRHS 1446

  Fly   839 VMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLF 903
            ...|......|.....|.|...:   .||.|         |.::                     
  Rat  1447 SHGSDVSLPQTSKLNRSRNHQSS---NGFFS---------HGVD--------------------- 1478

  Fly   904 YPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHP-KRDYIFCLSTAFGDAYLFQAPCQVELENWVN 967
             | :||||.|..|....:   :...|..|.|.| .|.:                     |.|.:.
  Rat  1479 -P-ESREGESEPAGSGEM---EEEEMDSITEVPANRSF---------------------LRNSMR 1517

  Fly   968 SIHSACAAAFARHR---GKT----------GTLHLLQEEIFR----------------LEKAIES 1003
            |:     :.|.||.   ||.          .::.:|...:.|                ...|:.:
  Rat  1518 SL-----SPFRRHSWGPGKNAASDAEMNQRSSMQVLGHVVRRPPIHRRSMSWCPSGVQYSAALNA 1577

  Fly  1004 DHKL----------------KHMAELQQSVVTDQETRH------QIQTQILQWEENLE---RLHC 1043
            |..:                |..:.|:.|.....|.|:      |..:.:...||:||   |.|.
  Rat  1578 DFNIRSFSLEGLTGGGGVGNKPSSSLEISSANSSELRNPFSGEEQRSSLMSLSEEHLEPDQRQHH 1642

  Fly  1044 EQF-RLRCYMASLQ---------SGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSP 1098
            ..| :..||.:..|         |..|....||:| :|.|        |:.....||:.....:.
  Rat  1643 RMFDQQTCYRSKQQGFNYCTSAISSPLTKSISLMT-ISHP--------GLDNSRPFHSASANLTE 1698

  Fly  1099 SLLN---NLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAM 1160
            |:..   |.|         ||       ..|::|.:..|..:..:||.           |:|:.|
  Rat  1699 SITEENCNFL---------PP-------SPSKKSFEEKSGTKVSRTFS-----------YIRNKM 1736

  Fly  1161 SVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEV--------- 1216
            |     :|..::..          :|.:|............:..:..|:.|.|..:         
  Rat  1737 S-----SSKKSKEK----------EKEKDKTKEKEKESKEKEKDKKTLNGHTFSPIPIVGPINCS 1786

  Fly  1217 -CMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVI 1280
             |||..                          ..:|...|     ......:|.|..:       
  Rat  1787 QCMKPF--------------------------TNKDAYTC-----ASCGAFVHKGCRE------- 1813

  Fly  1281 NGAIVSDLDMMYLESVLQEEQSLSM---MMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTD--- 1339
            |.|..:.:.|...:..||...:.|:   :||:..::|.:.   .|....:.:..:..|..|:   
  Rat  1814 NLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKER---PRSAVLLAEEAIAAPMFTNRRS 1875

  Fly  1340 ------PPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQ----LAVGGVG 1394
                  ...:|.:.|||:        |..:::.:.....|.:|..::......:    |...|||
  Rat  1876 QQSVSLSKSVSIQNITGV--------GNDENMSNTWKFLSHSTDSLNKICKVNESTESLTDEGVG 1932

  Fly  1395 GVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKV 1459
            ..:..|..:....|.:...|.|:..:|.:.:..|                   :|..|..|.::|
  Rat  1933 TDMNEGQLMGDFESDSKQLEAESWSRTVDSKFLK-------------------QQKKDVVKRQEV 1978

  Fly  1460 VMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNL----EES 1520
            :.||:.||..:::.|..:.:.|...|..:.......:..||..:.|:::...||.|.:    :||
  Rat  1979 IYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2043

  Fly  1521 LDLEPDFNKFEHCGQFRNVLF-AIGSAFLYYVNHF---------KLYSSFCASHSKAQ---KVLH 1572
            |     .:|.|     :|.|. .||...   |:.|         |.|..||..|:::.   |.|:
  Rat  2044 L-----VDKSE-----KNFLIKRIGDVL---VSQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 2095

  Fly  1573 PNEGNHALQEFLAARNPKQQHSSTLESYLIKP------IQRILKYPLLLQQMRNLTDTRADEHVH 1631
            ..:  ...|.|:     |::.||::...|..|      .|||.|||:|.|::...|.....|...
  Rat  2096 TKD--KRFQAFV-----KKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2153

  Fly  1632 LCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDF 1696
            |.::|..::.|             .||: |.....::|..:                        
  Rat  2154 LTQSLSLVKDV-------------IGAV-DSKVASYEKKVR------------------------ 2180

  Fly  1697 LGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLM--GVSSKNATNEVEIIRYQVLIPVTEVQV 1759
            ||:|....:..:: ...||..:| .||.||:||.:.  .|..|:||..::.::..:|   |::.|
  Rat  2181 LGEIYTKTDSKSI-MRMKSGQMF-AKEDLRRKKLVRDGSVFLKSATGRLKEVQAVLL---TDILV 2240

  Fly  1760 RASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKN 1824
                                 .||.:.:| ||.  ::.|.::..:...:.|:||           
  Rat  2241 ---------------------FLQEKDQK-YVF--ASLDHKSTVISLKKLIVRE----------- 2270

  Fly  1825 FGGSSGSVSGHSSQGMG--SMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDY 1887
                    ..|..:|:.  |||       ::.|  ::..||.|         |..:|:|...|..
  Rat  2271 --------VAHEEKGLFLISMG-------VKDP--EMVEVHAS---------SREERNSWIQIIQ 2309

  Fly  1888 DNLSG-SQEADDLPPSVGVVHYASGHTHG----QQMQPAG------FRGRSKTVGDVTEITCSSP 1941
            |.::. :::.|:..||..........|..    :|:|...      ...:.....|:||  ||:|
  Rat  2310 DTINSLNRDEDEGIPSENEEEKRLLDTKARELKEQLQQKDQQILLLLEEKEMIFRDMTE--CSTP 2372

  Fly  1942 EP------HQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERID--- 1997
            .|      |..:...:...::.::.|                      |.:....|::|.:.   
  Rat  2373 LPEDCSPTHSPRMLFRSNTEEALKGG----------------------PLMKSAISEVEILQGLV 2415

  Fly  1998 ----PGT-----KSEGEEDSQQGTI---RPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSH 2050
                .||     .|..|::...|.|   |...|.|....|       .|:....|.         
  Rat  2416 SGSLGGTLGQPISSPVEQEVMAGPISLPRRAETFGGFDCH-------QLNASKGGE--------- 2464

  Fly  2051 PPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQ 2115
                      |:.|....|....||:|           .|..|.:.:|.....|:::...::...
  Rat  2465 ----------KEEGDDGQDLRRTESDS-----------GLKKGGNANLVFMLKRNSEQVVQSIVH 2508

  Fly  2116 IHSLHPSPRQSPRQSPRQSPKQDIEVIE------------IFESEAERLAASQQVAVVHQHPSDQ 2168
            :|.|....:....|.......|.:.:.|            :.|.|.:|....|:..:.:.. ..|
  Rat  2509 LHELLTMLQGVVLQQDSYIEDQKLVLTEKVLTRSASRPSSLIEQEKQRSLEKQRQDLANLQ-KQQ 2572

  Fly  2169 ARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAED 2233
            |:....|:||:|:....|.:    ..|:.....|:|             |::|.:   .|||..|
  Rat  2573 AQHLEEKRRREREWEARELE----LRDREAKLAERE-------------ETVRRR---QQDLERD 2617

  Fly  2234 TGDHQQNDSSLSPE------PQTIVENTQQTVVVDIESPSRPATESD--STGNTTGPSER----- 2285
            ..:.||...:...:      .|..:|..|:.:..|.|..|:...|.|  ...|..|...|     
  Rat  2618 REELQQKKGTYQCDLERLRAAQKQLEREQEQLKRDAEQLSQRQMEQDLCQVSNKHGRLMRVPSFL 2682

  Fly  2286 -SGDE-----TEEEATTSSLASHIVVIDKK--VDKIFKAKSP----ERPASTKVKGGRRQIYISP 2338
             :.||     |.....:.||.|.:.|..|:  :.:..|.|.|    ...:.|||..|:.|     
  Rat  2683 PNSDEFSLLSTPSITKSGSLDSELSVSPKRNSISRTQKDKGPFHILSSASQTKVPEGQSQ----- 2742

  Fly  2339 DRCKSQGSSPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRT-----PSPRRSSEG 2396
              ..|..|:..|:..:..|:.....:.|               |.|.||     |:|...:||
  Rat  2743 --APSSTSTSTRLFGLSKPKEKKEKKKK---------------SKGSRTQPGDGPAPEVPAEG 2788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674 8/29 (28%)
PH1_Tiam1_2 860..985 CDD:269937 24/138 (17%)
PH 873..974 CDD:278594 16/101 (16%)
TIAM1_RBD 1141..1219 CDD:176413 13/87 (15%)
PDZ_signaling 1221..1308 CDD:238492 10/89 (11%)
RhoGEF 1456..1647 CDD:238091 52/213 (24%)
PH2_Tiam1_2 1650..1823 CDD:269957 32/174 (18%)
PH 1693..1812 CDD:278594 26/120 (22%)
Akap13XP_038961459.1 PHA03307 545..>837 CDD:223039 41/173 (24%)
C1_AKAP13 1769..1824 CDD:410428 12/92 (13%)
RhoGEF 1975..2169 CDD:238091 54/227 (24%)
PH_AKAP13 2212..2314 CDD:275427 30/165 (18%)
SMC_prok_B <2509..>2669 CDD:274008 35/180 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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