DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Pura

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster


Alignment Length:2034 Identity:379/2034 - (18%)
Similarity:628/2034 - (30%) Gaps:739/2034 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 VKAKRKPLSTPASPSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTL-----PRNVGSHRITDVDG 225
            ::..|:.|......|.||.|.:..|..|:..|.|||..:: |.|.|     |....:..:.    
  Fly   347 IQQARERLVCGFDGSLVRFEQRFLCKFAQIAATLRTAHQI-GESWLWHPGWPLATSNGALV---- 406

  Fly   226 QQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQD--VANSGVNTNTPGVI 288
             .|:...::..|:..:.||  :......|...||..||.....:..|::  |.:..::...||.:
  Fly   407 -LQLSDAEIAHALRPSELY--LCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHENPGEL 468

  Fly   289 VTGV----------GNVGSDMCG------QN---HVGSQVGNDDPAACQMDMDLSKSEGTQAGGG 334
            ...|          ..:.|| ||      ||   .|...:........||.|...:.|.:     
  Fly   469 PLSVLQLEMSTAAAALMASD-CGELPQLLQNLLVSVERSIERVSLNELQMPMHHDRGEDS----- 527

  Fly   335 LHQSVGTCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNN--TRRKTKSTEDMN------- 390
                    ...:...|..|...|........|..:.::.:.|:.  .||.|...:.||       
  Fly   528 --------LDEANNNGCNNNLLGSPKCALRRSDLITKNKLFNSRYMLRRLTNRQDSMNSTSSGNS 584

  Fly   391 --VDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYY--NANAAQT--------LGHP-PHMHQHGM 442
              .|.|:.........:.|..:||....:.|.|..  .|:.|.|        ||:. ||:.....
  Fly   585 NVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEE 649

  Fly   443 AMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPS 507
            |  ....|.|.||.:        .:..:....|.|..|:........:||...|   .::|.|  
  Fly   650 A--SDSIGPGKHHSL--------ETCETELLPSSSIAELPEKLLTSGVYLPGTR---TLQGDP-- 699

  Fly   508 DNVMFDNQC-----------------YATTPSSS----------------NGNSDQDQSYGQQQS 539
             .|..|..|                 |:|.|..|                ||:...:|   |||.
  Fly   700 -LVTVDAACVASAGINCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQ---QQQQ 760

  Fly   540 SGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTF 604
            ..|..||:|.|.|::.                   |..:.:|...||     ..:|....||.  
  Fly   761 QQQQQQQKQQPAQQTF-------------------TILIAIEKSQHL-----CVIDLICQSLR-- 799

  Fly   605 EALLSQSMENLEFAESLPGS--------------------NQRSPYPLRRPNAKS---------- 639
              ||::.:.|.|.....|.|                    |..|.:|  .|::.|          
  Fly   800 --LLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHP--EPSSPSPVDLVKFISV 860

  Fly   640 ---------STLP---LPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSF 692
                     |.||   ||....|||:         .|.....::..:.||               
  Fly   861 DQVTTSVAPSQLPAGLLPSVPALSTL---------PGISQRHHDATKWRE--------------- 901

  Fly   693 SNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSS 757
                            :|...:.::...||.|.                           |..|:
  Fly   902 ----------------FFAQLEAFQRQCSTAGG---------------------------RLVSA 923

  Fly   758 LNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDD 822
            |::                 ||...|:.  |..|...||..:..|....||::..|.        
  Fly   924 LSE-----------------IRAADLQG--LPTRRQLYGQHRALSRALMDSQLHSLR-------- 961

  Fly   823 RMSLTTAVSDEDDGESVMASPYKAKATG-TAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARK 886
            :|........:|...::.::|...:.|. ..:||.:.:||     ||:|           :.|.|
  Fly   962 KMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGA-----FLNV-----------DAACK 1010

  Fly   887 RGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDA 951
                     |:..||||...|....|                ::.:.|..:.             
  Fly  1011 ---------LRKVTLLFNEVDRAAQR----------------LEQLTEQRRE------------- 1037

  Fly   952 YLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLH-------LLQEEIFRLEKAIESDHKLK- 1008
            .|.|...|..||:.::.:.|...:..|.:..|...||       ..||:.|.....|...|..| 
  Fly  1038 RLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKG 1102

  Fly  1009 ---HMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHV 1070
               |.|.|:.||::  |:.:.:::.:.|:.:.||..| |::.        .:|.|.:   |||..
  Fly  1103 RDLHAAALKVSVLS--ESANNLKSALDQFAQKLELAH-ERYD--------AAGRLLH---LLTQH 1153

  Fly  1071 SRPT------KNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRS 1129
            .|..      :....:||..::...|..:..::.:|               |:.|.:.:.::.:.
  Fly  1154 QRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTL---------------PVASSTPAAAAGKR 1203

  Fly  1130 MQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHN 1194
            :..........:|: ..|.::..:.:                             ::.|::||  
  Fly  1204 VSYRCSSASRSSFE-GGPSSSNCSCW-----------------------------RESRNLED-- 1236

  Fly  1195 YFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSR 1259
                                                ::||         .|..|.||..|     
  Fly  1237 ------------------------------------MDQM---------EEEEEEQDHDC----- 1251

  Fly  1260 VEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVT 1324
                     :|   ||.                     :|:||                   ::.
  Fly  1252 ---------DG---GDG---------------------EEQQS-------------------KIA 1264

  Fly  1325 DDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKD-LYSPEAESSPATSFVD----PAAM 1384
            |..:.  ||.....:|.:       ..|......|..|.| |...|....|:..::|    |...
  Fly  1265 DSGLG--VCDNCERNPKL-------ARICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEA 1320

  Fly  1385 AAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQ 1449
            .|.|...|                  ||.|:..|                    ...:.|.|..|
  Fly  1321 NAHLQCHG------------------SSLELPKL--------------------EELSCLDPKIQ 1347

  Fly  1450 LTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLS--NAEINALFGNIHEIVTFQR- 1511
            .|    |..::.|::.|||.||:.|..::|:|::.:.||....  ..:.|.:||||.:|..|.. 
  Fly  1348 KT----LLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNS 1408

  Fly  1512 QFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEG 1576
            .||..||          ::|     ||.| .:|:|||...:.|.||:.:..:..|:..:|     
  Fly  1409 HFLGELE----------RYE-----RNPL-KVGAAFLEMESKFYLYALYNKNKPKSDTLL----- 1452

  Fly  1577 NHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKG--M 1639
            :.....|...:..:.|....|.|||:||:||:.||.|||||:           |..|:.::|  :
  Fly  1453 SEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQL-----------VKACKGVEGAAL 1506

  Fly  1640 EKVAEHINEMQRIHE------EYGAIFDHLFRQHQKSC-----KQPIDLSPGDLLYYGGVEWLNI 1693
            :::|..:.|:||..|      .:|.  |.|.....:.|     :|...|...:.|.:.|      
  Fly  1507 QEIAADVEELQRAEEMVKFQLRHGN--DLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQG------ 1563

  Fly  1694 SDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQ 1758
                   :.|.:.....|:|:..|:|....|....|.|            :|..|:..|..:::.
  Fly  1564 -------RGGKKTLRQVFLFEELVLFSKARRFPDHKNL------------DIYIYKNSIKTSDIG 1609

  Fly  1759 VRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQII-RESVRNMSI-- 1820
            :.|.:........:|    .|   :|:.:..::|...:.|.:||:.:.|.::: :::.||..:  
  Fly  1610 LTAHTGDSATKFEIW----FR---KRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRL 1667

  Fly  1821 -----------PMKNFGGSSGSVSG---------------HSSQGMGSMGYPGNSQTLERPKQQI 1859
                       |..:...|:..:|.               ||..|.|||..| ||...|......
  Fly  1668 AEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRP-NSLISESSLSSG 1731

  Fly  1860 TIVHGSHTLGKPKKKSGSQRHSAG----NIDYDNLSGSQEADDL-------------------PP 1901
            |    |.|.|.......|..|:.|    ::.:..|.|:..|...                   .|
  Fly  1732 T----STTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSP 1792

  Fly  1902 SVGVVHYA-----SGHTHGQ-QMQPAGFRG------RSKTV--------GDVTEITCSSPEPHQQ 1946
            |.|.:..|     .|:|.|. ......||.      ||.|:        |.|::: |.:|:..|.
  Fly  1793 SGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSMESGIVSDM-CVTPDQEQS 1856

  Fly  1947 QQQQQQQQQQLMQQGHAHA 1965
            ..:..:........|.:.|
  Fly  1857 AAESSRSSWSTSTTGASGA 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 23/124 (19%)
PH 873..974 CDD:278594 16/100 (16%)
TIAM1_RBD 1141..1219 CDD:176413 5/77 (6%)
PDZ_signaling 1221..1308 CDD:238492 13/86 (15%)
RhoGEF 1456..1647 CDD:238091 57/195 (29%)
PH2_Tiam1_2 1650..1823 CDD:269957 34/197 (17%)
PH 1693..1812 CDD:278594 20/119 (17%)
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 61/212 (29%)
PH_puratrophin-1 1524..1663 CDD:270062 29/172 (17%)
PH 1562..1655 CDD:278594 21/124 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462284
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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