Protein Alignment sif and ARHGEF16

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_016856538.1
• Gene: ARHGEF16 / 27237
• HGNCID: 15515
• Length: 726
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 131/604 - (21%)
• Similarity: 226/604 - (37%)
• Gaps: 152/604 - (25%)

  Fly  1315 PDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEE---MITGLIVPAPGWNGT--------------- 1361
            |.:.|..||.||.......|.||...|...||   ::.....||....||
Human    53 PMVRGSPRVRDDAAFQPQVPAPPQPRPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAK 117

  Fly  1362 -------------SKDLYSPEAESSPATSF--------VDPAAM--------AAQLAVGGVGGVV 1397
                         |::....:.:..||.||        .||..|        :.:.|:.|:|  .
Human   118 TPARHQSFGAAVLSREAARRDPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLG--K 180

  Fly  1398 VGGLGVA---------------KPTSRT---------------SSF--------EIENLLKTAEQ 1424
            .||.|.|               :|.:|:               .||        ||:.......|
Human   181 PGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQ 245

  Fly  1425 ET------RKSSPTGS--VTSSVSTTALTPSR----------------QLTDAEKLRKVVM-ELV 1464
            |:      ..|||.|:  |.:::...:..|::                ||:..|:.|:..| |::
Human   246 ESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEIL 310

  Fly  1465 DTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNK 1529
            .:|.:|...|:.|:|.:|:..:....::..|.:.||.||.:::...::|.::||:
Human   311 TSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQ---------- 365

  Fly  1530 FEHCGQFRNVLFAIGSAFL--YYVNHFKLYSSFCASHSKAQKVLHP-NEGNHALQEFL--AARNP 1589
             .|..|   ||....|..|  :...||..|.::|::....|:.|.. ...|.|.:|.|  ..|.|
Human   366 -RHKAQ---VLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRP 426

  Fly  1590 KQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINE----MQ 1650
            .......| |:||.|:||:.:.|||:..:...|...::.:.....|||.:.|:....||    |:
Human   427 ACGGLPML-SFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRME 490

  Fly  1651 RIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFK- 1714
            |:.:.|..   |......|....|:..:...||..|.:..:..:....||..    ...|::|.
Human   491 RMEQMYTL---HTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIAS----RPTCYLFLF 548

  Fly  1715 SAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLR 1779
            :.|:.:.|::..:...:...:..|.. :||.|....| |:.....|:||....     :::..||
Human   549 NDVLVVTKKKSEESYMVQDYAQMNHI-QVEKIEPSEL-PLPGGGNRSSSVPHP-----FQVTLLR 606

  Fly  1780 SQLQRRSEKVYVLSNSTAD 1798
            :. :.|.|::.:.|:|.:|
Human   607 NS-EGRQEQLLLSSDSASD 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	50/196 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	30/150 (20%)
		PH	1693..1812	CDD:278594	22/107 (21%)
ARHGEF16	XP_016856538.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910