DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and PLEKHG3

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_011534929.1 Gene:PLEKHG3 / 26030 HGNCID:20364 Length:1391 Species:Homo sapiens


Alignment Length:1490 Identity:306/1490 - (20%)
Similarity:496/1490 - (33%) Gaps:422/1490 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1353 VPAPGWNG---TSKDLYSPEAESSPA----------------TSFVDPAAMAAQLAVGGVGGVVV 1398
            ||:||.|.   .|..|:...::..|.                ::..:|::..|. |..|.|.:..
Human    13 VPSPGSNARMPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAP-AKNGAGSLRS 76

  Fly  1399 GGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMEL 1463
            ..|    |.|..:|....|:             .|.::...|..|..|:..  ....|.:||.|:
Human    77 RHL----PNSNNNSSSWLNV-------------KGPLSPFNSRAAAGPAHH--KLSYLGRVVREI 122

  Fly  1464 VDTERTYVKHLNNLLEHY-LEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDF 1527
            |:|||.||:.|.:::|.| |:.:.....|...:::||||||..|.....|.|::| :|.:.:|  
Human   123 VETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDL-DSCNSDP-- 184

  Fly  1528 NKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQ 1592
                         .|:.|.|:.....|.:|:.:|.::..:...|.....:....:|...|....|
Human   185 -------------VAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQ 236

  Fly  1593 HSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYG 1657
            ||..|.|||:||:||||||.||||::....|...|....:.:|:..|..||.:||:|:|.||   
Human   237 HSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHE--- 298

  Fly  1658 AIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKG-LELHAMCFVFKSAVVFLC 1721
                |..|. |:.....|:....||..||.:           :.:| ..:|              
Human   299 ----HAVRL-QEIQSLLINWKGPDLTTYGEL-----------VLEGTFRVH-------------- 333

  Fly  1722 KERLRQKK------KLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780
              |:|.::      |.:.::.|...:.|    |:..||.:.:.: ..|.:|.....:....|.:.
Human   334 --RVRNERTFFLFDKTLLITKKRGDHFV----YKGNIPCSSLML-IESTRDSLCFTVTHYKHSKQ 391

  Fly  1781 QLQRRSEKVYVLSNSTADFRNAFLK----TIRQIIRESVRNMS--IP---------MKNFGGSSG 1830
            |...:::.|....|.|...:...|:    ||.|..:|::..|.  .|         :|....|..
Human   392 QYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQD 456

  Fly  1831 SVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKP----KKKSGSQRHSAGNIDYDNLS 1891
            .||.:..||. ....||:|     |..:.|:..|......|    ::||...:|..         
Human   457 EVSTNVRQGR-RQSEPGHS-----PYSRATLPSGQRGFVMPSLKGRRKSEPTKHLL--------- 506

  Fly  1892 GSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQ 1956
              ::.::...:.|:.|..|..|.....||:..||........|:......|...::::::::::|
Human   507 --RQLNEKARAAGMKHAGSAGTLLDFGQPSRTRGLQPEAEGATQEEEEEEEEVVEEEEEEEEEEQ 569

  Fly  1957 LMQQGHAHAHPHPHPHPREPPPPP--------------------------IRQPHLHHHSSDIER 1995
            ..|........|........|.||                          :...|..|:.::...
Human   570 AFQVSLEDLTGHEGNEKGAGPEPPGSEEEEEEQEESLAVAEQVADFASSLLAALHCWHYRANALL 634

  Fly  1996 IDPGTKSEG--EEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPV 2058
            ...|...:|  |.:|.:.:.||.   ||:|.    ||...:|..|..|...:  ...|.|..:..
Human   635 FSRGAMGKGRRESESSRSSRRPS---GRSPT----STEKRMSFESISSLPEV--EPDPEAGSEQE 690

  Fly  2059 LMKDLGKPSPDESELESES-EVHAAQVAASFNLSLG--------------SSGSLFASDARDNQT 2108
            :...:..||.:|:..::|| ||...|:.|...| ||              |:..|.|..:.:.:.
Human   691 VFSAVEGPSAEETPSDTESPEVLETQLDAHQGL-LGMDPPGDMVDFVAAESTEDLKALSSEEEEE 754

  Fly  2109 QSRTQSQIHSLHP-----------------------------------SPRQSPRQSP------- 2131
            ......:..||.|                                   |||...|.|.       
Human   755 MGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGS 819

  Fly  2132 ----------------RQSPKQDIEVIEIFES----------------EAERLAASQQVA----- 2159
                            :.||:.||.|....|.                |.:|.:..::.:     
Human   820 EKGLARHGSATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTR 884

  Fly  2160 -------VVHQHPSDQARESGHKQRRDR-----------------------DRNPTETDATARFM 2194
                   :...:.:.:..::|...||..                       |..|.....:.|.:
Human   885 DRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQV 949

  Fly  2195 DKH----------------------LSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDH 2237
            ...                      :||.|..    .:.:||...|.:......|   .:..|..
Human   950 GSRPTSWALFELPGPSQAVKGDPPPISDAEFR----PSSEIVKIWEGMESSGGSP---GKGPGQG 1007

  Fly  2238 QQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSS---- 2298
            |.|...|. ||..|:|..:...:.:..:.:.|.:.|.:.|.:.....|...|..:|.::|:    
Human  1008 QANGFDLH-EPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGEL 1071

  Fly  2299 ---LASHIV----VIDKKVDKIFKAKSPE--RPASTKVKGGRRQI--------YISPDRCKSQGS 2346
               |...||    |:|..|.:..|.|..:  |..|.::|..:..:        .::|:|   .|.
Human  1072 VAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPER---DGK 1133

  Fly  2347 SPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGIL 2411
            ||......:.....|..:|||..|.|..|..|  |.|...:| |:.||.|               
Human  1134 SPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQ--LMAQEHSP-PKPSSAG--------------- 1180

  Fly  2412 KPPSSPAKSKSPDRSCLKKGGPSHVCSVETLSPRVSPRGSMDHLSPDRGMTSSSCLRHSPRSSFD 2476
                    ..||.|...   .||.| |..|.||...|..                  .||.|..:
Human  1181 --------EMSPQRFFF---NPSAV-SQRTTSPGGRPSA------------------RSPLSPTE 1215

  Fly  2477 SHGESD-HNLDVPHGSRKRSMSAHGSFETGTRPRAQETYQYYPVYDNQTCSDHYVAAAPTGRYGG 2540
            :....| ..|...:.||..:..|.|.     |||..      ||..:.:..::.|....:||.|.
Human  1216 TFSWPDVRELCSKYASRDEARRAGGG-----RPRGP------PVNRSHSVPENMVEPPLSGRVGR 1269

  Fly  2541 GTS-SRSRLSKSLERSTSRDSTTTSSSYGHRAYGVSPD------RNYVVFSSGPLRSQSA 2593
            ..| |..|.....|.:.|......|...|.....|:.|      |..:|...|||.|.:|
Human  1270 CRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADLTLEDNRRVIVMEKGPLPSPTA 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 61/191 (32%)
PH2_Tiam1_2 1650..1823 CDD:269957 35/194 (18%)
PH 1693..1812 CDD:278594 21/129 (16%)
PLEKHG3XP_011534929.1 RhoGEF 118..292 CDD:279015 61/189 (32%)
PH_PLEKHG1_G2_G3 274..417 CDD:270063 36/182 (20%)
PH 338..414 CDD:278594 13/80 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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