DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Fgd4

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_038943909.1	Gene:	Fgd4 / 246174	RGDID:	708357	Length:	887	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	109/504 - (21%)
Similarity:	186/504 - (36%)	Gaps:	143/504 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1367 SPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENL------------- 1418
            |||.::..|.:..|...:.                ||...|:..|:..:.|.
  Rat   232 SPETDTQTAAASPDAHVLN----------------GVRNETTTDSASSVTNSHDENACDSSCRTQ 280

  Fly  1419 -----LKTAEQETRKSSPTGSVTSSVSTTALTPSRQ-----LTDAEKLRKVVMELVDTERTYVKH 1473
                 |.:.|.|....:......:.:||..|.|..|     .|:.:||.|:..||:.|||.||..
  Rat   281 GTDLGLPSKEGEPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATELLLTERAYVSR 345

  Fly  1474 LNNLLEHY----LEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCG 1534
            ||.|.:.:    ||...|.:|.:.. :|.:|.||..|..|..:||  |.|   ||....::|...
  Rat   346 LNLLDQVFYCKLLEEANRGSFPAEM-VNKIFSNISSINAFHSKFL--LPE---LEKRMQEWETTP 404

  Fly  1535 QFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQH----SS 1595
            :..::|..: :.||      |:|..:......|.:::  ......:.:|.:.....|:.    |.
  Rat   405 RIGDILQKL-APFL------KMYGEYVKGFDNAVELV--KNMTERVPQFKSVTEEIQKQKICGSL 460

  Fly  1596 TLESYLIKPIQRILKYPLLLQQ-MRNLTDTRADEHVHLCEALKGMEKV---AEHINEMQRIHEEY 1656
            ||:.::::|||||.:|.:||:. ::.|:....|.:    :|.|.:|.:   |.|.|...|..|..
  Rat   461 TLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWN----DAKKSLEIISTAASHSNSAIRKMENL 521

  Fly  1657 GAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGK-----------IKKG--LELHA 1708
            ..:                               |.|.:.||:           ||:|  |:|.|
  Rat   522 KKL-------------------------------LEIYEMLGEEEDIVNPSNELIKEGQILKLAA 555

  Fly  1709 --------MCFVFKSAVVFLCKER---------LRQKKKLMGVSSKNATNEVEIIRYQVLIPVTE 1756
                    ..|:|.:.::: |..|         :|.:..:.|:......||.....:||......
  Rat   556 RNTSAQERYLFLFNNMLLY-CVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERT 619

  Fly  1757 VQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLK 1805
            ::::|||.:|.:.   |        ::...|.:.........||||..|
  Rat   620 LELQASSEQDKEE---W--------IKALQESIDAFHQRHETFRNAIAK 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	55/202 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	33/186 (18%)
		PH	1693..1812	CDD:278594	30/143 (21%)
Fgd4	XP_038943909.1	RhoGEF	328..512	CDD:238091	55/202 (27%)
		PH1_FDG4	544..637	CDD:275434	21/104 (20%)
		FYVE_FGD1_2_4	675..739	CDD:277280
		PH2_FGD1-4	758..860	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910