DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and PSD4

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_036587.2	Gene:	PSD4 / 23550	HGNCID:	19096	Length:	1056	Species:	Homo sapiens

Alignment Length:	1203	Identity:	223/1203 - (18%)
Similarity:	356/1203 - (29%)	Gaps:	479/1203 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPL------STPASPSRVRQEPQCTCMSAEQ 195
            ||.||..               |||         :|.      :.|..|:|....|.
Human    34 RETCSHE---------------DPP---------EPFEEQTWATDPPEPTRQNVPPW-------- 66

  Fly   196 YARLRTDPRVRGSSTLPRNVGS--HRITDVDG----QQQV----------------GSGKVVSAV 238
                       ||.....::||  |:    ||    |:|.                |||..::.:
Human    67 -----------GSGVELTHLGSWVHQ----DGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHL 116

  Fly   239 SSTSLY----DNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDM 299
            .|.|..    .|.||.|...|......|:|                |.:|...:|...|.:.:.|
Human   117 GSPSAQREHRQNTASPGSPVNSHLPGSPKQ----------------NRSTSTQVVFWAGILQAQM 165

  Fly   300 CGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAG---------------GGLHQSVGTCTSSSKGT 349
            |               ...::.:|.|:||.:||               .|||.|
Human   166 C---------------VLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTGLHSS----------- 204

  Fly   350 GTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPE 414
            ...|:|.|:|                         |:|......:.|:.        .:|.:||:
Human   205 PPENEDSGED-------------------------SSEPEGEGQAWLRE--------GTPDSSPQ 236

  Fly   415 MGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSH 479
            .|....:.:.:|..            .:|.........|...    :.|.:.|.:...:|..|..
Human   237 WGAEEESMFFSNPL------------FLASPCSENSASGECF----SWGASDSHAGVRTGPESPA 285

  Fly   480 EIGRGYPPRNLYLELERERSCIEG-------SPPSDNVMF--DNQCYATTPSS--------SNGN 527
            .:....|...:..|||.|....:|       :||....::  .:.|:|:..::        .:|.
Human   286 TLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGE 350

  Fly   528 SDQDQ--------------------SYGQQQSSGQHPQQ----------QQGPP----------Q 552
            |:.|:                    ..|.......||.|          |:|.|          .
Human   351 SEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQD 415

  Fly   553 RSSRHQHHHQQ------------APNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFE 605
            |..|...|.|:            :|..:|.|.||.|.   ......|.:.|...:......|...
Human   416 RDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESE---SRGPGPRPSPASSQEGSPQLQHHSS 477

  Fly   606 ALL-------SQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKER-DRDR 662
            .:|       |||        ||..::...|..|::..|..:..|....:...|.|..|. |...
Human   478 GILPKWTLDASQS--------SLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQP 534

  Fly   663 DGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGS 727
            |.:       :...|.|..|   :..|||                        |..||.
Human   535 DIH-------LTSAEHENLR---TPMNSS------------------------WLPGSP------ 559

  Fly   728 GHGMMTQQIPGSGHKRSPWDSLPS-LRQDS---SLNDSGY------KSARADSLEQRAEFIRQDS 782
               |...|.|..|.:....|.|.: :|.:.   :|....|      ||..|..|::..:|.|  :
Human   560 ---MPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSR--A 619

  Fly   783 LRSEYLS---------DR---------------ESRYGIVQQ-------------ASIESTDSRM 810
            :..||||         ||               :.|..|:.|             .|::|..:..
Human   620 VAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLT 684

  Fly   811 CYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVK---- 871
            |.:          |.|.|.:..::.|:|:....:.....|..... |....:.||.:.|::
Human   685 CAI----------MLLNTDLHGQNIGKSMSCQEFITNLNGLRDGG-NFPKELLKALYWSIRSEKL 738

  Fly   872 KW------------------------------------------LLRKKHQIELAR-----KRGW 889
            :|                                          |.||.||....:     ||||
Human   739 EWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGW 803

  Fly   890 KGYWVCLKGTTLLFYP-----C---DSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLST 946
            |.:...|:|..|.|..     |   :|..|:.|:..    :.|..::..|...:.|:.::|.|.|
Human   804 KMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEP----VGVHHSLATPATHYTKKPHVFQLRT 864

  Fly   947 AFGDAYLFQAPCQVELENWVNSIHSACAAAFA-----------------------------RHRG 982
            |....||||||...|:.:|:..|:.|.|...|                             :||.
Human   865 ADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSLEEQHRS 929

  Fly   983 KTGTLHLLQEEIFRLEKAI-ESDHKLKHMAE--LQQSVVTDQETRHQIQTQILQWEENLERLHCE 1044
            ....|....:::..|::.: |...:.:.:.|  |::..:..::||::...|:|     :.||||.
Human   930 HENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLL-----VARLHCP 989

  Fly  1045 QFRLRCYMASL--QSGELPNPK-SLLTHVSRPT 1074
            ...|..:...|  ::|....|| ||....|.|:
Human   990 SDALDLWEEQLGREAGGTREPKLSLKKSHSSPS 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674	4/6 (67%)
		PH1_Tiam1_2	860..985	CDD:269937	43/212 (20%)
		PH	873..974	CDD:278594	36/155 (23%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
PSD4	NP_036587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..71		14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..149		15/77 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..239		14/87 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..362		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..533		31/155 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..581		13/70 (19%)
		Sec7	570..738	CDD:238100	33/180 (18%)
		PH_EFA6	772..900	CDD:270107	37/131 (28%)
		PH	794..892	CDD:278594	30/101 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1056		7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910