DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and DNMBP

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens


Alignment Length:1847 Identity:358/1847 - (19%)
Similarity:612/1847 - (33%) Gaps:587/1847 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   715 GWRSGSSTIGS-GSGHGMMTQQIPGSGHKRSPWDSLPSLRQ--DSSLNDSGYKSARADSLEQRAE 776
            ||..|.|..|: |.......:::..|...|. |.|..:|.|  :.|:..:......:..|::..:
Human   102 GWLQGRSCWGARGFFPSSCVRELCLSSQSRQ-WHSQSALFQIPEYSMGQARALMGLSAQLDEELD 165

  Fly   777 FIRQDSLR-------SEYLSDRESRYGIVQQA-------------SIESTDSRMCYLT------- 814
            |...|.:.       ..:..:.|.|.||..:.             |:.|.:...|.:.       
Human   166 FREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPV 230

  Fly   815 -SSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKK 878
             ..||..|:         ||::..:...:.|:.:|.......|.....:|               
Human   231 GEEEIGPDE---------DEEEPGTYGVALYRFQALEPNELDFEVGDKIR--------------- 271

  Fly   879 HQIELARKRGW-KGYWVCLKGTTLLFYP------CDSREGRSVEAAPKHLIIVDGAIMQPIPEHP 936
              |....:.|| :|   .|||.|.:| |      |.........|.|:     :|::.: |||  
Human   272 --ILATLEDGWLEG---SLKGRTGIF-PYRFVKLCPDTRVEETMALPQ-----EGSLAR-IPE-- 322

  Fly   937 KRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAI 1001
              ..:.||....|          ||.:....|.|.|                   ||    ...|
Human   323 --TSLDCLENTLG----------VEEQRHETSDHEA-------------------EE----PDCI 352

  Fly  1002 ESDHKLKHMAELQQSVVTDQETRHQIQT-------QILQWEENLERLHCEQFRLRCYMASLQSGE 1059
            .|:.....:..|.....||:.:.....|       ..::||                |.......
Human   353 ISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWE----------------MPLATDSP 401

  Fly  1060 LPNPKSLLTHVSR----PTKNTLNKLGVF-TVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLS 1119
            ..:|..::..:|.    |....|.|...: ||...|.. ..:.|.||              |:.:
Human   402 TSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPH-SEQYPDLL--------------PLEA 451

  Fly  1120 RSNSGSSRRSMQMNSRDEPEKTF-KVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVR 1183
            |:...:|....:|.|:   .||. |..:|      :|...::|         |.|.:.|      
Human   452 RTRDYASLPPKRMYSQ---LKTLQKPVLP------LYRGSSVS---------ASRVVKP------ 492

  Fly  1184 VKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQV--ELQRTTLEQMWGFSVEAELIEN 1246
              ::...:.||         :.:|...|....|     |.:  .|:.....|..|..:||.....
Human   493 --RQSSPQLHN---------LASYTKKHHTSSV-----YSISERLEMKPGPQAQGLVMEAATHSQ 541

  Fly  1247 AERQDELCCYVSR--VE-DKSVA----MHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLS 1304
            .:...:|...:::  :| :||:|    ..:.|::...||..|    |:.|::...|.|..||.|.
Human   542 GDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFN----SEKDIVRGSSKLITEQELP 602

  Fly  1305 MMMRSSRTEPP-DLVGIMRVTDDMIDSLVCPPPPTD---------PPVMSEEMITGLIVP----- 1354
            ...::.|..|| ....:......::|..:.|.||..         ||  |.:..|..:.|     
Human   603 ERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPP--SAQQRTNAVSPKLLSR 665

  Fly  1355 -----------APGWNGTSKDLYSP--------------------------------EAESSPAT 1376
                       .||..|.|.|..||                                :.|||.|.
Human   666 HRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDESSRAE 730

  Fly  1377 SFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSS---PTGSVTSS 1438
            :..|                    |...:....:.:.|::.|.:.....::.||   |:|||   
Human   731 TLED--------------------LKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSV--- 772

  Fly  1439 VSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNI 1503
               :|..|.:::  .||..||:.||:.|||.|::.|...:|..:.|| ::..:.|.:...||||:
Human   773 ---SAENPEQRM--LEKRAKVIEELLQTERDYIRDLEMCIERIMVPM-QQAQVPNIDFEGLFGNM 831

  Fly  1504 HEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKA 1567
            ..::...:|.|..||                    :..|:|..||.:.:..: .|..:|.:|.:|
Human   832 QMVIKVSKQLLAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEA 876

  Fly  1568 QKVLHPNEGNHALQEFL--AARNPKQQHSS-------TLESYLIKPIQRILKYPLLLQQMRNLTD 1623
            ..:|...|.:..:|:.|  :..:.|..::.       .|.|:||||:||:::|||||.::.|.|.
Human   877 IALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTP 941

  Fly  1624 TRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGV 1688
            ....:.|.|..|:..::::..:|||.:|..:        |..:::|..:..:         ...:
Human   942 ESHPDKVPLTNAVLAVKEINVNINEYKRRKD--------LVLKYRKGDEDSL---------MEKI 989

  Fly  1689 EWLNISDFLGK---IKKGLELHAMCFV--FKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRY 1748
            ..|||...:.|   :...|: |...|.  .|..|....::..|.:::|:....::.:..::.||.
Human   990 SKLNIHSIIKKSNRVSSHLK-HLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE 1053

  Fly  1749 QVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQ-RRSEKV--YVLSNSTADFRNAFLKTIRQI 1810
            ...:.|    |.|.|        :|::...|.... .:.|:|  |:......:|:.   :|.|.:
Human  1054 SACVKV----VAAVS--------MWDVCMERGHRDLEQFERVHRYISDQLFTNFKE---RTERLV 1103

  Fly  1811 IRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKS 1875
            |  |..|..:.|  |.|....|.....:   .:.:...::..|:.|.               ||:
Human  1104 I--SPLNQLLSM--FTGPHKLVQKRFDK---LLDFYNCTERAEKLKD---------------KKT 1146

  Fly  1876 GSQRHSAGNIDYDNLSGSQEADDLPPSVGVVH-YASG----HTHGQQMQPAGFRGRSKTVGDVTE 1935
            ..:..||.| :|:.|: :|..|:||.    .| ||.|    ..||                 ..|
Human  1147 LEELQSARN-NYEALN-AQLLDELPK----FHQYAQGLFTNCVHG-----------------YAE 1188

  Fly  1936 ITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHL-----HHHSSDIER 1995
            ..|..  .||..:|.:.....|...|                    |:.:|     ..||..:::
Human  1189 AHCDF--VHQALEQLKPLLSLLKVAG--------------------REGNLIAIFHEEHSRVLQQ 1231

  Fly  1996 ID---------PGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHP 2051
            :.         |.||...|..:.......|..|| .|::                   ::||...
Human  1232 LQVFTFFPESLPATKKPFERKTIDRQSARKPLLG-LPSY-------------------MLQSEEL 1276

  Fly  2052 PASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSS---GSLFASDARDNQTQ---- 2109
            .||        |....|.|...::|...:|||   ..::||...   |.:...|...:|.:    
Human  1277 RAS--------LLARYPPEKLFQAERNFNAAQ---DLDVSLLEGDLVGVIKKKDPMGSQNRWLID 1330

  Fly  2110 -SRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESG 2173
             ..|:..::|....|     .:||:|           .|:|.          |..|.|.::....
Human  1331 NGVTKGFVYSSFLKP-----YNPRRS-----------HSDAS----------VGSHSSTESEHGS 1369

  Fly  2174 HKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQ 2238
            ...|..|.    .:.:|..|....::    .:.|.|:|          :|  .|||.:....:..
Human  1370 SSPRFPRQ----NSGSTLTFNPSSMA----VSFTSGSC----------QK--QPQDASPPPKECD 1414

  Fly  2239 QNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDET-------EEEATT 2296
            |...|.|..|    .|::       .||||..::.|||.     ..||||..       :..||.
Human  1415 QGTLSASLNP----SNSE-------SSPSRCPSDPDSTS-----QPRSGDSADVARDVKQPTATP 1463

  Fly  2297 SSLAS--HIVVIDKKVDKIFKAKSPERPASTK--VKGGRRQIY------ISPDRCKSQGSS---P 2348
            .|..:  |..::...|        |.|...::  |||..|...      ..||..:::|:.   .
Human  1464 RSYRNFRHPEIVGYSV--------PGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFA 1520

  Fly  2349 VRIIKIKSPRTSLSDQGKRLSVCSSRD 2375
            |...|.::|........::|.:...:|
Human  1521 VYTFKARNPNELSVSANQKLKILEFKD 1547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 26/131 (20%)
PH 873..974 CDD:278594 25/107 (23%)
TIAM1_RBD 1141..1219 CDD:176413 13/78 (17%)
PDZ_signaling 1221..1308 CDD:238492 22/95 (23%)
RhoGEF 1456..1647 CDD:238091 52/200 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 31/180 (17%)
PH 1693..1812 CDD:278594 23/126 (18%)
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729 6/20 (30%)
SH3_DNMBP_N3 149..199 CDD:212730 7/49 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 8/41 (20%)
SH3_DNMBP_N4 247..296 CDD:212731 14/69 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395 14/98 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659 4/21 (19%)
RhoGEF 788..966 CDD:279015 52/198 (26%)
BAR_DNMBP 1017..1208 CDD:153273 49/252 (19%)
SH3_DNMBP_C1 1289..1345 CDD:212732 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487 42/203 (21%)
SH3_DNMBP_C2 1517..1573 CDD:213017 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3224
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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