Protein Alignment sif and ARHGEF9

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_001340852.1
• Gene: ARHGEF9 / 23229
• HGNCID: 14561
• Length: 529
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 126/549 - (22%)
• Similarity: 221/549 - (40%)
• Gaps: 142/549 - (25%)

  Fly  1437 SSVSTTALTPS-------RQLTDAEKLR-KVVMELVDTERTYVKHLNNLLEHYLEP-MKRETFLS 1492
            |.|....|.|:       |.|.:.:::| .|:.|::.|||.|:|||.::.|.||:. .||....|
Human    90 SDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFS 154

  Fly  1493 NAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLY 1557
            :.::..:||||.:|..||..|:::||:..:     |...|       |..||..||.:.:.|.:|
Human   155 DEQLKVIFGNIEDIYRFQMGFVRDLEKQYN-----NDDPH-------LSEIGPCFLEHQDGFWIY 207

  Fly  1558 SSFCASHSKA----QKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQM 1618
            |.:|.:|..|    .|::..:...|.   |.|.|..:|.....::.:|:.|:|:|.||||.|.::
Human   208 SEYCNNHLDACMELSKLMKDSRYQHF---FEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAEL 269

  Fly  1619 RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSC-----KQPIDLS 1678
            ...|.....::.::..||..|..|.:.|||.:|..|....|     .|.|.|.     :..:|.|
Human   270 LKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKI-----AQWQASVLDWEGEDILDRS 329

  Fly  1679 PGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEV 1743
             .:|:|.|.:.|:       ....|.....:.|:|...:| |||:.|.::..|.      ....:
Human   330 -SELIYTGEMAWI-------YQPYGRNQQRVFFLFDHQMV-LCKKDLIRRDILY------YKGRI 379

  Fly  1744 EIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQ---RRSEKVYVLSNSTADFRNAFLK 1805
            ::.:|:|        |.....:|.|.:     :.:::..:   :.:|::::......:.:..:|:
Human   380 DMDKYEV--------VDIEDGRDDDFN-----VSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLR 431

  Fly  1806 TIRQ---IIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHT 1867
            ..|:   :::|..:                          :|:    :..|..|:|..:     |
Human   432 AFREERKMVQEDEK--------------------------IGF----EISENQKRQAAM-----T 461

  Fly  1868 LGK-PKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGH---THGQQMQPAGFRGRSK 1928
            :.| ||:|                 |...|..:|||     |....   .|||.:.|.|.
Human   462 VRKVPKQK-----------------GVNSARSVPPS-----YPPPQDPLNHGQYLVPDGI----- 499

  Fly  1929 TVGDVTEITCSSPEPHQQQQQQQQQQQQL 1957
            ....|.|.|    ||.:.|....|...:|
Human   500 AQSQVFEFT----EPKRSQSPFWQNFSRL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	59/196 (30%)
		PH2_Tiam1_2	1650..1823	CDD:269957	30/183 (16%)
		PH	1693..1812	CDD:278594	17/124 (14%)
ARHGEF9	NP_001340852.1	SH3_ARHGEF9	20..81	CDD:212908
		RhoGEF	120..299	CDD:214619	59/193 (31%)
		PH_Collybistin_ASEF	304..443	CDD:269931	28/171 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840