DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and MCF2L2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_055893.4 Gene:MCF2L2 / 23101 HGNCID:30319 Length:1114 Species:Homo sapiens


Alignment Length:1323 Identity:232/1323 - (17%)
Similarity:432/1323 - (32%) Gaps:460/1323 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   925 DGAIMQPIPEH------PKRDYIFCLSTAFGDAYLFQAPCQVEL-------------ENW--VNS 968
            |||.:...||.      |..|::..::      ||...| .||.             :.|  |.:
Human    59 DGAPIITFPEFSGFKHIPDEDFLNVMT------YLTSIP-SVEAASIGFIVVIDRRRDKWSSVKA 116

  Fly   969 IHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIE---SDHKLKH----------------MAELQ 1014
            ..:..|.||      .|.|.|:  .|.|..:.|:   :|..:|:                :::|.
Human   117 SLTRIAVAF------PGNLQLI--FILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLH 173

  Fly  1015 QSVVTDQETRH---QIQTQILQWEENLERLHCEQF---------RLRCYMASLQSGELP-----N 1062
            ..:...|.||.   .::.:..||..:  |...|.|         .|:.:.:.|.:.|||     .
Human   174 GYIDKSQLTRELGGTLEYRHGQWVNH--RTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLST 236

  Fly  1063 PKSLLTHVSRPTK-----NTLNKLGVFTVSSFH--AFICARSPSLLNNLLAGRGATKRRPPMLSR 1120
            ...|::|..:..|     ..|.|.|...:|...  |..|..|...||.|               .
Human   237 EDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQL---------------E 286

  Fly  1121 SNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLR--DAMSVEEFLASAC----ARRNL---- 1175
            :.:...|..:|:   ||.||.|     .:.:|..:|:  ..:.::.|....|    |..||    
Human   287 NVTTMERLLVQL---DETEKAF-----SHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQ 343

  Fly  1176 -------NPMEHFVRV-KKRRDMEDHNYFVPHRNDLI----ENYLHNHEFV-----EVCMKILYQ 1223
                   :.:.|..:: |:.:.:|:.:.....:..|:    :..:.:|.:.     ..|:::.:.
Human   344 AEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHL 408

  Fly  1224 VELQRTTLEQMW---GFSVEAELIENAERQDELC-----CYVSRVEDKSVAMHNGIIKGDEIMVI 1280
            .:......::.|   |.|:|..  ...::..:.|     ...|:..||..:.....|..::|...
Human   409 CDDFINGNKKKWDILGKSLEFH--RQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATF 471

  Fly  1281 NGAI-----------VSDLDMMY-----------------LESVLQEEQSLSMMMRSSRTEP--P 1315
            .|.:           .::.:::.                 ::.:..:.|...|.:.:.:|.|  |
Human   472 LGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQP 536

  Fly  1316 DLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVD 1380
                            |.|.|.:.|..:|.:                        .|.|:||   
Human   537 ----------------VAPHPESSPKWVSSK------------------------TSQPSTS--- 558

  Fly  1381 PAAMAAQLAVGGVGGVVVGGLGVAKP--TSRTSSFEIE-NLLKTAEQETR---KSSPTGSVTSSV 1439
                                :.:|:|  ||.....|.| |.....:.||:   ||..........
Human   559 --------------------VPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHER 603

  Fly  1440 STTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMK--------RETFLSNAEI 1496
            ....|....:|.|....|:::.:|::||..|:|.:.::::.|:.||.        .:...:|.:.
Human   604 GNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDF 668

  Fly  1497 NALFGNIHEIVTF-QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSF 1560
              |||||.|:..| .|.||:.||:..: .|:.  ..||             ||......::|..:
Human   669 --LFGNIRELYEFHNRTFLKELEKCAE-NPEL--LAHC-------------FLKRKEDLQIYFKY 715

  Fly  1561 CASHSKAQKVLHPNEGNHALQE-----FLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRN 1620
            ..:..:|:.:         .||     :......:..|:..|..||..|.||::||.:||   :.
Human   716 HKNLPRARAI---------WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLL---KG 768

  Fly  1621 LTDTRADEHVHL------CEALKGMEKVAEHI--NEMQRIHEEYGAIFDHLFRQHQKSCKQPIDL 1677
            |.|..:.|.:.:      ..|..|.::..:..  .|:|:..    |:.:.|.    |||:..:||
Human   769 LLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQAL----AVIEDLI----KSCELAVDL 825

  Fly  1678 SP-----------GDLLYYGGVEWLNISDFLGKIKKGLEL---HAMCFVFKSAVVFLCKERL--- 1725
            :.           |.||.:|......|.....|:|..:..   ....::|:..:|| ||.|:   
Human   826 AAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVF-CKIRMEPG 889

  Fly  1726 ----------RQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780
                      ::..|||.:|.:..                          ...||..:| |..|:
Human   890 DQGLSPHYSFKKTMKLMTLSIRQL--------------------------GRGSHRKFE-IASRN 927

  Fly  1781 QLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGY 1845
            .|::     |:|..::.:.|:.:...|.:::.|...|    :|:.|.....:|.....|.||..:
Human   928 GLEK-----YILQAASKEIRDCWFSEISKLLMEQQNN----IKDQGNPQFEMSTSKGSGAGSGPW 983

  Fly  1846 PGNSQTLERPKQQITIVHGSHTLGKPKKKSG-----SQRHSAGNIDYDNLSGSQEADDLPPSVGV 1905
            ..|.:.....|:.            |...:|     |.|..:....:::..|:::.:....::.:
Human   984 IKNMERATTSKED------------PASSTGGIKGCSSREFSSMDTFEDCEGAEDMEKESSALSL 1036

  Fly  1906 VH-YASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHP 1969
            .. :.|..:|.                     ||||.....::.:..|.:::             
Human  1037 AGLFQSDDSHE---------------------TCSSKSAFLERGESSQGEKE------------- 1067

  Fly  1970 HPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTL 2034
                                    ||.:..|.:...|:.:.|.                ||....
Human  1068 ------------------------ERDEEETATRSTEEERAGA----------------STGRLA 1092

  Fly  2035 SVGST-GSQARLIQSSHPPASYQ 2056
            ..|:| |.|||.::   |..|.|
Human  1093 PAGATAGFQARALR---PRTSAQ 1112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 17/80 (21%)
PH 873..974 CDD:278594 14/69 (20%)
TIAM1_RBD 1141..1219 CDD:176413 14/104 (13%)
PDZ_signaling 1221..1308 CDD:238492 13/122 (11%)
RhoGEF 1456..1647 CDD:238091 47/212 (22%)
PH2_Tiam1_2 1650..1823 CDD:269957 37/199 (19%)
PH 1693..1812 CDD:278594 23/134 (17%)
MCF2L2NP_055893.4 SEC14 52..190 CDD:214706 29/145 (20%)
SPEC 321..523 CDD:238103 23/203 (11%)
Spectrin 323..428 14/104 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..614 24/146 (16%)
RhoGEF 623..820 CDD:214619 52/234 (22%)
PH-like 827..956 CDD:418428 27/161 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1114 35/240 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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