back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and ARHGEF15

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_011522036.1	Gene:	ARHGEF15 / 22899	HGNCID:	15590	Length:	856	Species:	Homo sapiens

Alignment Length:	713	Identity:	147/713 - (20%)
Similarity:	249/713 - (34%)	Gaps:	219/713 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1307 MRSSRTEP-PDLVGIMRV--------TDDMIDSLVCPPPPT----------DPP-----VMSEEM 1347
            :|:||:.| |..:|...|        .:..:..|:.||.||          |||     ::||:.
Human   244 LRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDG 308

  Fly  1348 ITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSS 1412
            |.         .|.|.| .:|: .:.|||                |.|....||.|.|..:....
Human   309 IQ---------TGDSPD-EAPQ-NTPPAT----------------VEGREEEGLEVLKEQNWELP 346

  Fly  1413 FEIENLLKT------AEQ-----ETRKSSPTG----------------------SVTSSVSTTAL 1444
            .:.|.|.:|      :|:     |....||..                      :|.:|.....|
Human   347 LQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTL 411

  Fly  1445 TPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHY-LEPMKRETFLSNAEINALFGNIHEIVT 1508
            :|..:     ::::.:.|:|.:|.:|::.|..|.:.: |....|:| |:..:.:.||.|:..:..
Human   412 SPQER-----RMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDT-LTPRDHHTLFSNVQRVQG 470

  Fly  1509 FQRQFLQNLEESLDLEPDFNKFEHCGQFRNVL--FAIGSAFLYYVNHFK-------LYSSFCASH 1564
            ...:||..|...:...|      |.....:|:  .|:| .|..||::.:       .||....::
Human   471 VSERFLATLLSRVRSSP------HISDLCDVVHAHAVG-PFSVYVDYVRNQQYQEETYSRLMDTN 528

  Fly  1565 SKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMR---------- 1619
            .:....|      ..||..     ||.:. ..|.|:|:.|.|||.:..:|||..|
Human   529 VRFSAEL------RRLQSL-----PKCER-LPLPSFLLLPFQRITRLRMLLQGHRAGGPVTLPPC 581

  Fly  1620 --NL---TDTRADEHVHLCEALKGMEKVAEHIN-EMQRIHEEYGAIFDHLFRQHQKSCKQPIDLS 1678
              |:   |:..:....:..:||..:.|:.|..: |:.|:.:.     :.|.|..|:.....:...
Human   582 PQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQT-----EELIRLTQRLRFHKVKAL 641

  Fly  1679 PGDLLYYGGVEWLNISDFLGKI-----KKGLELHA-------MCFVFKSAVVFLCKERLRQKKKL 1731
            |       .|.|....:|.|::     ::|..|.|       :|.:..|.::.:.:.:..|
Human   642 P-------LVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQ---- 695

  Fly  1732 MGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNST 1796
                           |.|||.......|:|....|......:.| .|.|..|.|.....:.::|.
Human   696 ---------------RLQVLDYAHRSLVQAQQVPDPSGPPTFRL-SLLSNHQGRPTHRLLQASSL 744

  Fly  1797 ADFR---NAF---------LKTI-------RQIIRESVRNMSIPMKNFGGSSGSVSG----HSSQ 1838
            :|.:   .||         ..||       :::..||    |.|.|..|.|..|.:.    |.:.
Human   745 SDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSES----SAPAKTEGRSLESRAAPKHLHKTP 805

  Fly  1839 GMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPP 1901
            .....|.||     ..|.|.:..|.|.|...:..:::.....:.|     :.||:..|   ||
Human   806 EGWLKGLPG-----AFPAQLVCEVTGEHERRRHLRQNQRLLEAVG-----SSSGTPNA---PP 855

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.