DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and PLEKHA6

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_006711275.1	Gene:	PLEKHA6 / 22874	HGNCID:	17053	Length:	1301	Species:	Homo sapiens

Alignment Length:	1485	Identity:	275/1485 - (18%)
Similarity:	447/1485 - (30%)	Gaps:	561/1485 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PGTRIG----QAS---------------ECFVYWKDPMTNDTWGLNFTSPIDAKQFR-ECCSPSF 144
            |.|:.|    |||               .|..|:||.......|     .|....|| ....||.
Human   167 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILG-----SIPLLSFRVAAVQPSD 226

  Fly   145 KFSRK------------ASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQEPQCTCMSAEQYA 197
            ..|||            |.:|.:..|.|      :|:...:.|....:...:|.:....:..:.|
Human   227 NISRKHTFKVTVCWVDEAEASSTRCLSP------QAEHAGVRTYFFSAESPEEQEAWIQAMGEAA 285

  Fly   198 RLRTDPRVRGSSTLPRNV-GSHRITDVDGQQQVGSGKVVSAVSSTSL---YDNVASGGPGTNQGA 258
            |::..|   ...::|:.| .||...|   .:.|...|........||   .....:.|.|..:|.
Human   286 RVQIPP---AQKSVPQAVRHSHEKPD---SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGC 344

  Fly   259 DTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDL 323
            :...|     :.:|.:|...      |.|...|: ..|.:      ..|:.|:..|
Human   345 EKAER-----RPERPEVKKE------PPVKANGL-PAGPE------PASEPGSPYP--------- 382

  Fly   324 SKSEGTQAGGGLHQSV--------------GTCTSSSKG-TGTRNKDFGDDMTRDAHSHDMHQHN 373
               ||.:..||..|..              .|...|..| ||...:.|......|..:......|
Human   383 ---EGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMN 444

  Fly   374 VINN--NTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLG---- 432
            .:..  |.||.....||:.            .||...||:     ||...||...::|...
Human   445 QLQQWVNLRRGVPPPEDLR------------SPSRFYPVS-----RRVPEYYGPYSSQYPDDYQY 492

  Fly   433 HPPHMHQHGMAM------------------GMGGGGGGGHHI----------------------- 456
            :||.:....:..                  ....|||..:.:
Human   493 YPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSR 557

  Fly   457 --MNNNTMGRASSQSSRFSGSRSSHEIGR-----GYPPRNLYLELERERSCIEGSPP-SDNVMFD 513
              :..:.:..|||...|.|....||.:.|     .|....:|..:....:..|..|| |:::..|
Human   558 QPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYAD 622

  Fly   514 NQCYATTPSSSNGNSDQDQSYGQQQ--SSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTS 576
            ...|....|.|:...|.   .|.::  .:|..|...  ||                :||......
Human   623 PAAYVMRRSISSPKYDY---LGDRRPVPAGLFPYNY--PP----------------SPTVHDKMD 666

  Fly   577 RLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAESLPGSN---QRSPYP-LRRPNA 637
            .||   ::.|:..| :.:|.:.....|..:::::.:||     |.|.|.   |..||| :.|.:
Human   667 ELL---DLQLQRNL-EYLDQQMSESETLISMVNRMVEN-----SSPRSQLFMQVPPYPEVFRDS- 721

  Fly   638 KSSTLPLPPHRPLSTIRDKERDRDR-DGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCI 701
                        |.|.:..|:|.|: .|...::|:::||::|
Human   722 ------------LHTYKLNEQDTDKLLGKLCEQNKVVREQDR----------------------- 751

  Fly   702 GESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPS--LRQDSSLNDSGYK 764
                                          :.||:      |:..:||.|  :.....|...|.:
Human   752 ------------------------------LVQQL------RAEKESLESALMGTHQELEMFGSQ 780

  Fly   765 SARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCY-LTSSEIS---DD--DR 823
            .|..:.|..     ::|||:::.::.|..    :.||:...|:|.:.| ...||:|   ||  ::
Human   781 PAYPEKLRH-----KKDSLQNQLINIRVE----LSQATTALTNSTIEYEHLESEVSALHDDLWEQ 836

  Fly   824 MSLTT--------------AVSDEDDG----------ESVM-------ASPYKAKATGTAASSFN 857
            ::|.|              .:.|..:|          ::..       ::.|.:.:..:..||.:
Human   837 LNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSAS 901

  Fly   858 CTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLI 922
            .|..:.....:|                  |.:|              ..::.|.:.|..|
Human   902 LTSPLSPFSLVS------------------GSQG--------------SPTKPGSNEEPGP---- 930

  Fly   923 IVDGAIMQPIPEHPKRDYIFCLSTAFGDAYL-FQAPCQVELENWVNSIHSACAAAFARHRGKTGT 986
                    |.|..||             ||: .::|..|.
Human   931 --------PRPPLPK-------------AYVPLESPPAVP------------------------- 949

  Fly   987 LHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCY 1051
             .|..|..|....:..|.|:....|..|.....:|..:...||..|....::..:...|
Human   950 -PLPSESRFWPYPSSPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQ------ 1007

  Fly  1052 MASLQSGELPNPKSLLTHVSRPTKNTLNKLGV------------FTVSSFHAFICARSPSLLNNL 1104
                             .|....:..|||:||            .|.|:    :..|:.|.|.|.
Human  1008 -----------------EVEAEKQAALNKVGVVPPRTKSPTDDEVTPSA----VVRRNASGLTNG 1051

  Fly  1105 LA------------GRGATK----RRPPMLSRSNSGS---SRRSMQMNSRDEPEKTFKVAMPDNA 1150
            |:            |.|..|    .:...:.|..|||   .|||:|:.:...|:.:     |..|
Human  1052 LSSQQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPS-----PRPA 1111

  Fly  1151 YSTVYLRDAMSVEEFLASACARRNL---------------NPMEHFVRVKKRRDMEDHNYFVPHR 1200
            |..|  |...|:.|...|     ||               .|.|...|::| .::|..:|.|...
Human  1112 YKVV--RRHRSIHEVDIS-----NLEAALRAEEPGGHAYETPREEIARLRK-MELEPQHYDVDIN 1168

  Fly  1201 NDLI--ENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDK 1263
            .:|.  :..|....:::               ||.....|.| ||.|..::.:.:...:::...:
Human  1169 KELSTPDKVLIPERYID---------------LEPDTPLSPE-ELKEKQKKVERIKTLIAKSSMQ 1217

  Fly  1264 SVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQ-----SLSMMMRSSRTEPPDLVGIMRV 1323
            :|.   .|.:||.:.|...:          ||.|||::     |.::...:||.      |.|.
Human  1218 NVV---PIGEGDSVDVPQDS----------ESQLQEQEKRIEISCALATEASRR------GRML- 1262

  Fly  1324 TDDMIDSLVC--PPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPAT 1376
                  |:.|  |.|||.|           ..|||..|..|.:  ||....|..|
Human  1263 ------SVQCATPSPPTSP-----------ASPAPPANPLSSE--SPRGADSSYT 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674	15/63 (24%)
		PH1_Tiam1_2	860..985	CDD:269937	14/125 (11%)
		PH	873..974	CDD:278594	13/101 (13%)
		TIAM1_RBD	1141..1219	CDD:176413	19/94 (20%)
		PDZ_signaling	1221..1308	CDD:238492	18/91 (20%)
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
PLEKHA6	XP_006711275.1	PH_PEPP1_2_3	162..285	CDD:270068	26/128 (20%)
PLEKHA6	XP_006711275.1	PH	168..286	CDD:278594	25/128 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910