| Sequence 1: | NP_001261446.1 | Gene: | sif / 43892 | FlyBaseID: | FBgn0085447 | Length: | 2734 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004454.2 | Gene: | FGD1 / 2245 | HGNCID: | 3663 | Length: | 961 | Species: | Homo sapiens |
| Alignment Length: | 883 | Identity: | 177/883 - (20%) |
|---|---|---|---|
| Similarity: | 313/883 - (35%) | Gaps: | 256/883 - (28%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1293 LESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITG------- 1350
Fly 1351 LIVPAP--GWNGTSKD-----LYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTS 1408
Fly 1409 RTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKH 1473
Fly 1474 LN--------NLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQF-LQNLEESLDLEPDFNK 1529
Fly 1530 FEHCGQFRNVLFAIGSAFLYYVNHF----KLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPK 1590
Fly 1591 QQHSSTLESYLIKPIQRILKYPLLLQQ-MRNLTDTRADEHVHLCEALKGMEKV---AEH----IN 1647
Fly 1648 EMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSP-GDLLYYGGVEWLNISDFLGKIKKGLELHAMCF 1711
Fly 1712 VFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELI 1776
Fly 1777 HLRSQLQRRSE---KVYVLS-NSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSS 1837
Fly 1838 QGMGSMGYPGNSQTLERPKQQITIVHGSHT-----LGKPKKKSGSQRH---SAGNI--------- 1885
Fly 1886 ---DYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQ 1947
Fly 1948 QQQQQQQQ------------QLMQQGHAHAH------PHPHP-------HPR------------- 1974
Fly 1975 EPPPP------------PIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLT 2027
Fly 2028 LSTTSTLS---------VGSTGSQARLIQSSHPPASYQ 2056 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| sif | NP_001261446.1 | WH1 | 35..144 | CDD:214674 | |
| PH1_Tiam1_2 | 860..985 | CDD:269937 | |||
| PH | 873..974 | CDD:278594 | |||
| TIAM1_RBD | 1141..1219 | CDD:176413 | |||
| PDZ_signaling | 1221..1308 | CDD:238492 | 1/14 (7%) | ||
| RhoGEF | 1456..1647 | CDD:238091 | 49/211 (23%) | ||
| PH2_Tiam1_2 | 1650..1823 | CDD:269957 | 34/177 (19%) | ||
| PH | 1693..1812 | CDD:278594 | 26/122 (21%) | ||
| FGD1 | NP_004454.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..353 | 30/153 (20%) | |
| SH3-binding. /evidence=ECO:0000255 | 171..187 | ||||
| RhoGEF | 376..559 | CDD:238091 | 49/205 (24%) | ||
| PH1_FGD1 | 591..698 | CDD:275392 | 28/128 (22%) | ||
| PH | 591..688 | CDD:278594 | 26/118 (22%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 702..726 | 5/23 (22%) | |||
| FYVE_FGD1_2_4 | 725..789 | CDD:277280 | 10/71 (14%) | ||
| PH2_FGD1-4 | 815..920 | CDD:270056 | 23/118 (19%) | ||
| PH | 823..921 | CDD:278594 | 23/111 (21%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 925..961 | 10/38 (26%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||