DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Spata13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_036014454.1 Gene:Spata13 / 219140 MGIID:104838 Length:1295 Species:Mus musculus


Alignment Length:1866 Identity:351/1866 - (18%)
Similarity:557/1866 - (29%) Gaps:750/1866 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 RKPLSTPASP-SRVRQEPQCTCMSAEQYARLRTDPRVRG------SSTLPRNVGSHRITDVDGQQ 227
            ||.::....| :..|.|.|...:..|   .|...|.|.|      .:..|:|:    .|..||..
Mouse     3 RKAVAVTTDPDAHSRCESQAAVLGDE---GLEQGPPVTGVNGGLSQAAHPKNM----TTAQDGHG 60

  Fly   228 Q-------VGSGKVVSAVSSTSLYDNVASGGPGTNQGA-------DTLPRQMKGGQQDRQDVANS 278
            |       ..:.|....|:|::..:......|.::..|       ..|.|...|.::.    .||
Mouse    61 QGATATCSASNPKAPKMVTSSACQNGGCKSSPSSDPEAGETRLSPSKLVRLFSGSRKR----MNS 121

  Fly   279 GVNTNTPGVIVTGVGN-------------------VGSDMCG-QNHVGSQVGNDDPAACQMDMDL 323
              |:..|..:|. |||                   ..|.:.| ||..|::|..::|..   |...
Mouse   122 --NSERPRSVVL-VGNSSTWNALASFRKMGSFKRLKSSVLQGIQNREGAEVSKEEPTG---DPGR 180

  Fly   324 SKSEGTQA--GGGLHQSVGTCTS---SSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKT 383
            :...||.|  |.||    |.|||   ...|.|:...|..|  |.||.....|:...|........
Mouse   181 AAPNGTVAILGKGL----GRCTSLGPVGDGAGSDCSDPED--TEDAFQRSTHRSRSIRRAYGLGR 239

  Fly   384 KSTEDMNVDTSTLKRMLKPMPST-ESPVTSPEMGR-----RRYNYYNANAAQTLGHPPHMHQHGM 442
            .|..|       |.|...|.|:. |..|..||..|     ||     :.:..:|.          
Mouse   240 ISLLD-------LGRQPVPEPAVCEIQVRDPEPSRAVPLPRR-----SKSIDSLS---------- 282

  Fly   443 AMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNL---YLELER----ERSC 500
                         ::.::...:::|..:...|.|.       .|.|.|   :.:.|:    ||..
Mouse   283 -------------VLKSSFKRKSASNLTELQGDRQ-------VPSRTLSSFFTDPEKPGGSERRT 327

  Fly   501 IEGSPPSDNVMFDNQC----------------YATTPSSSNGNSDQD----------QSYGQQQS 539
            .....|.....||...                .:..|....|..|::          ..|.::.|
Mouse   328 RRWRSPIRAKDFDRVLRLVSNVKDAAWKREAPRSAAPGPGPGLGDENPLLAPRSKLHDDYSRRTS 392

  Fly   540 SGQHPQQQQG-----PPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESY 599
            |...|..::|     |             ||..|....:|        |.||      .:|...:
Mouse   393 SSVEPDARRGGSPCIP-------------APCTTAPYAAP--------EPHL------DVDTAVF 430

  Fly   600 SLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDG 664
            .|.|..|   |.:.|       .|....||.|          :|..|                  
Mouse   431 PLETKSA---QPLGN-------DGPRASSPSP----------IPTDP------------------ 457

  Fly   665 YYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGH 729
                                                             :|...|||...:||.|
Mouse   458 -------------------------------------------------EGLSQGSSEAHTGSQH 473

  Fly   730 GMMTQQIPGSGHKRSPWDSLP----SLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSD 790
            .....|:|......:|....|    |.:..|||:.....|  |||.|           |:|..|.
Mouse   474 PFNPVQLPTPLRPTTPKPQSPQSPGSTKCPSSLSVLSLSS--ADSEE-----------RTEDASH 525

  Fly   791 RESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASS 855
            |:.  |.|   |::.|                   :..|..|. .|||           |.:...
Mouse   526 RQP--GPV---SLQDT-------------------VLNAAGDV-GGES-----------GDSYFP 554

  Fly   856 FNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKH 920
            .|..||....          .||.:: |..:..|.                   :|.::|.... 
Mouse   555 ENLDGATHPE----------EKKEEV-LVTEDDWP-------------------QGSALEEEQN- 588

  Fly   921 LIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTG 985
                                              :|| ::....|.:...:       |.|..:.
Mouse   589 ----------------------------------EAP-RISRRRWGSGRRT-------RPRPLSD 611

  Fly   986 TLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRC 1050
            ...|....:...|.||.:|             ..|              |::::|:|        
Mouse   612 YGQLAGRSLSIPEDAIAAD-------------PPD--------------EDHVDRMH-------- 641

  Fly  1051 YMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRP 1115
                        |.|:.|....|                    ||.|.|.       ||..:|||
Mouse   642 ------------PASVTTTSQDP--------------------CAPSGSC-------RGGRRRRP 667

  Fly  1116 PMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACAR-------- 1172
                                      ..|....:.|....:.|   ||..|....||        
Mouse   668 --------------------------ISVIGGVSFYGNTQVED---VENLLVQPAARPPVPAHQV 703

  Fly  1173 -------RNLNPMEH-------FVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQ 1223
                   ..|.|...       ..||.:||.|:..|                             
Mouse   704 PPYKAVSARLRPFTFSQSTPIGLDRVGRRRQMKTSN----------------------------- 739

  Fly  1224 VELQRTTLEQMWGFSVEAELIENAERQD----ELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAI 1284
                   :....|....|.:.:|...:|    |||          .|....:..|.|.:.|| .:
Mouse   740 -------VSSDGGAESSALVDDNGSEEDFSYEELC----------QANPRYLQPGGEQLAIN-EL 786

  Fly  1285 VSDLDMMYLES----VLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSE 1345
            :||..::..|:    |..::|.|..       :..|::.::..::                    
Mouse   787 ISDGSVVCAEALWDHVTMDDQELGF-------KAGDVIQVLEASN-------------------- 824

  Fly  1346 EMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRT 1410
                     ...|.|.::|     .|:....|||.......:|                 |.:.:
Mouse   825 ---------KDWWWGRNED-----KEAWFPASFVRLRVNQEEL-----------------PENCS 858

  Fly  1411 SSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLR-KVVMELVDTERTYVKHL 1474
            ||...|.     :::|.|:...            .|..|    :::| .|:.|:::|||.|:|||
Mouse   859 SSHGEEQ-----DEDTSKARHK------------HPESQ----QQMRTNVIQEIMNTERVYIKHL 902

  Fly  1475 NNLLEHYLEPMKRET-FLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFE-HCGQFR 1537
            .::.|.|:...::.| ..:.|::..:||||.:|..|||:||:      |||..:||.| |     
Mouse   903 KDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLK------DLEKQYNKEEPH----- 956

  Fly  1538 NVLFAIGSAFLYYVNHFKLYSSFCASHSKA----QKVLHPNEGNHALQEFLAARNPKQQHSSTLE 1598
              |..|||.||.:...|.:||.:|.:|..|    ..::..::..|.   |.|.|..:|.....|:
Mouse   957 --LSEIGSCFLEHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHF---FEACRLLQQMIDIALD 1016

  Fly  1599 SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHL 1663
            .:|:.|:|:|.||||.|.::...|.....::.::..|.:.|:.||..|||.:|..|.    .|.:
Mouse  1017 GFLLTPVQKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLES----IDKI 1077

  Fly  1664 FRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFL---GKIKK----GLELHAMCFVFKSAVVFLC 1721
            .|...            .::.:.|::.|:.|..|   |::.|    |.....:.|:|...:|...
Mouse  1078 ARWQV------------SIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCK 1130

  Fly  1722 KERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQ-VRASSAKDMDSHFLWELIHLRSQ---L 1782
            |:.||:                :::.|:..:.:.||: |.....:|.|    |.| .||:.   :
Mouse  1131 KDLLRR----------------DMLYYKGRMDMDEVELVDVEDGRDKD----WSL-SLRNAFKLV 1174

  Fly  1783 QRRSEKVYVL----SNSTADFRNAFLKTIRQIIRESVRNMSIP--MKNFGGSSGSVSGHSSQGMG 1841
            .:.:::|::.    ....|.:..|:....|::..:....|.||  .|.....:...:||..    
Mouse  1175 SKATDEVHLFCARKQEDKARWLQAYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGK---- 1235

  Fly  1842 SMGYPGNSQTLERPKQQITIVHGSH-------------TLGKPKKK 1874
            |.||  ||..:..|.|.:..:|..|             .|.:||:|
Mouse  1236 SKGY--NSCPVAPPHQSLPPLHQRHITVPTSIPQQQVFALAEPKRK 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 13/124 (10%)
PH 873..974 CDD:278594 9/100 (9%)
TIAM1_RBD 1141..1219 CDD:176413 16/99 (16%)
PDZ_signaling 1221..1308 CDD:238492 18/94 (19%)
RhoGEF 1456..1647 CDD:238091 63/197 (32%)
PH2_Tiam1_2 1650..1823 CDD:269957 34/189 (18%)
PH 1693..1812 CDD:278594 25/133 (19%)
Spata13XP_036014454.1 PHA03247 <251..497 CDD:223021 61/394 (15%)
SH3_ASEF 777..848 CDD:212906 18/112 (16%)
RhoGEF 887..1066 CDD:214619 63/194 (32%)
PH_Collybistin_ASEF 1071..1209 CDD:269931 30/174 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.