DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Plekhg1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006512502.1 Gene:Plekhg1 / 213783 MGIID:2676551 Length:1487 Species:Mus musculus


Alignment Length:1501 Identity:312/1501 - (20%)
Similarity:489/1501 - (32%) Gaps:519/1501 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1333 CPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVV 1397
            ||.|..|...|....:.|.:|  .||..          .|||..:.:.|||...|          
Mouse    13 CPSPQQDHRNMLSTTMVGTLV--RGWRN----------RSSPRRAELKPAAPQRQ---------- 55

  Fly  1398 VGGLGVAK------------------PTSRTSSFEIENLLKTAEQETRKSSPT------GSVTSS 1438
             ||:.:.:                  |..||::...|    :.|.:|.:.|.:      ||.:||
Mouse    56 -GGIRIHETDGHRHLQLDVPSAVSLVPDPRTTAEPSE----SPEPKTMELSDSDRPISFGSTSSS 115

  Fly  1439 VST--------------------------------TALTPSRQLTDAEKLR-------------- 1457
            .|:                                ..|.|:|..:.:|..|              
Mouse   116 ASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSE 180

  Fly  1458 -------------------------------KVVMELVDTERTYVKHLNNLLEHYLEPMKRETFL 1491
                                           :||.|:::||||||:.|.:::|.|||.::.:|.|
Mouse   181 KQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKL 245

  Fly  1492 S--NAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF 1554
            .  ..:..||||||.:|..|..:.||:|             |:|   .|...||...|:.....|
Mouse   246 PLVTEDRAALFGNIQDIYHFNSELLQDL-------------ENC---ENDPVAIAECFVSKSEEF 294

  Fly  1555 KLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMR 1619
            .:|:.:|.::.::..||.....|..|.:|...|....:||..|.|||:||:||||||.|||.::.
Mouse   295 HIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIE 359

  Fly  1620 NLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQ-----KSCKQPIDLSP 1679
            |..|...:.:..:.:|:..|::||.|||:|:|.||       |..|..:     .:.:.|...|.
Mouse   360 NHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHE-------HAVRLQEIQSLLTNWEGPDLTSY 417

  Fly  1680 GDLLYYGGVEWLNISDFLGKIKKGLELHAM------------CFVFKSAVVFLC----------K 1722
            |:|:..|...       :.|.||...|..:            .|.:|:.:  ||          |
Mouse   418 GELVLEGTFR-------IQKAKKERTLFLLDQLLLITKKRDDTFTYKAHI--LCGNLMLVEVIPK 473

  Fly  1723 ERL--------------------RQKKKL------------------MGVSSKNATNEVEIIRYQ 1749
            |.|                    :|.|:|                  :...:|.|..|::.|.|.
Mouse   474 EPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYP 538

  Fly  1750 --VLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIR 1812
              ...|..|::....||.        ..:..:|:...||.||...|.::.|        |:::.|
Mouse   539 GFCYSPEGEMKTPCGSAP--------HRLRRKSEPSSRSHKVLKTSETSQD--------IQKVSR 587

  Fly  1813 E---SVRNMSIP-MKNFGGSSGSVSGHSSQGMG------------------------SMGYPGNS 1849
            |   |....::| .:|....|.:|......|.|                        |...|..:
Mouse   588 EESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQEN 652

  Fly  1850 QTLERPKQQITIVHGSHTLGKPK--KKSGSQR--------------HSAGNIDYDNLSGSQEADD 1898
            :..:...|.......|..|...:  :::.|.|              .|:|:......|.:.|::.
Mouse   653 EDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNA 717

  Fly  1899 LPPSVGV-----VHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLM 1958
            .||.|.:     ..|..|.......:|.|.||.: ..|...|:|....:                
Mouse   718 CPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMT-PYGSSVELTIDDID---------------- 765

  Fly  1959 QQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSS--DIERIDPGTKSEGE---EDSQQGTIRPKAT 2018
                                      |::.:.|  |: ::....:.|.|   ....:.::|||:|
Mouse   766 --------------------------HVYDNISFEDL-KLMVAKRDETECSFSKPSRDSVRPKST 803

  Fly  2019 -----LGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESE 2078
                 ..|..:|.|.|..|....|..|.:|. .||.|.....:..:...:|.|.|....| :.|.
Mouse   804 PELAFSKRQVSHSTSSLHSRKEAGLGGQEAS-TQSVHEHQEVEENIYDTIGLPDPPSMNL-NHSS 866

  Fly  2079 VHAAQVAASFNLSLG-----------SSGSLFAS--DARDNQTQSRTQSQIHSLHPSPR-QSPRQ 2129
            :|..:.:....|...           |..||..|  |...:|..|.|: .:..|:.||| ..|..
Mouse   867 LHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTE-YLSLLYDSPRCNLPIA 930

  Fly  2130 SPRQSPKQDIEVIEIF-----------ESEAERLAASQQVAVVHQHPSDQARE-----SGHKQRR 2178
            ....|.|...||.||:           :...:||.|:..|:      .|.|.|     |.|:..|
Mouse   931 DKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVS------KDDAPERLYVDSTHELGR 989

  Fly  2179 DRDRNPTETDATARFMDKHLSDL-----EQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDH- 2237
            |..               |.:.:     .|..|..|...:|   .:.|.......|:....|.. 
Mouse   990 DTG---------------HATSMLALPTSQTFLLPGKSRVV---RASRANCSLDNDIISTEGSFL 1036

  Fly  2238 QQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASH 2302
            ..|..||:.:... |:|.     .|:.:.|.|.|:.::    ..|.....|:|  ::....:|..
Mouse  1037 SLNQLSLASDGPP-VDNP-----YDLANCSLPQTDPEN----PDPGMEVTDKT--KSRVFMMARQ 1089

  Fly  2303 IVVIDKKVDKIFKAKSPE---------RPA--------STKVKGG---------RRQIY------ 2335
            .....|||::|.|.||||         ||:        ..|.:||         ..|:|      
Mouse  1090 YSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFR 1154

  Fly  2336 ----------------------ISPDRCKSQGS-----SPVRIIKIK--SPRTSLSDQGKRLSVC 2371
                                  :||.:.:..|.     ||....::.  ||:|....:.|.....
Mouse  1155 ETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITL 1219

  Fly  2372 SSRDNSQDR-LSAGRRTPS---------------------PRRSSEGGGILKHTTGPDPGILKP- 2413
            .|....:.| ||.....||                     |.:.:.|...|.::.|......|| 
Mouse  1220 ESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQ 1284

  Fly  2414 PSSPAKSKSP---DRSCLKKGGPSHVCSVETLSPRVSPRGSMDHLSP---------DRGMTSSSC 2466
            |.|..:|.|.   ::|......||...:.:.||.:.||||:.....|         |||..|...
Mouse  1285 PYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLT 1349

  Fly  2467 LRHSPR 2472
            |:.|.:
Mouse  1350 LQDSQK 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 67/237 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 45/243 (19%)
PH 1693..1812 CDD:278594 31/180 (17%)
Plekhg1XP_006512502.1 RhoGEF 211..387 CDD:238091 66/191 (35%)
PH_PLEKHG1_G2_G3 369..514 CDD:270063 32/160 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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