DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Sptbn1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_787030.2 Gene:Sptbn1 / 20742 MGIID:98388 Length:2363 Species:Mus musculus


Alignment Length:2605 Identity:445/2605 - (17%)
Similarity:817/2605 - (31%) Gaps:893/2605 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 INNNTRRKTKSTEDMNVDT---STLKRMLKPMPSTESPVTSPEMGRRRYN-YYNANAAQTLGHPP 435
            :|::..|.:....|:..|.   ..|.::|:.:.....|  .|..||.|.: ..|.:.|.......
Mouse    64 VNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLP--KPTKGRMRIHCLENVDKALQFLKEQ 126

  Fly   436 HMHQHGMAMGMGGGGGGGHHIMNNN---TMGRASSQSSRFSGSRSSHEI---------------- 481
            .:|...|         |.|.|::.|   |:|...:...||.....|.|.                
Mouse   127 RVHLENM---------GSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLW 182

  Fly   482 ----GRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTP--------SSSNGNSDQDQSY 534
                ..|||..|::......|         |.:.|:...:...|        ..||.:.:...::
Mouse   183 CQMKTAGYPNVNIHNFTTSWR---------DGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAF 238

  Fly   535 GQQQSSGQH--------PQ--QQQGPPQRS-----SRHQHHHQQAPNVTPTPGSPTSRLLLEYEM 584
            ...:   ||        |:  ....|.::|     ..:.|:.           |....|.:|.: 
Mouse   239 NLAE---QHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYF-----------SKMKALAVEGK- 288

  Fly   585 HLRNTLAKGMDAESYSLHTFEALLSQSME----------NLEFAESLPGSNQRSPYPLRRPNAKS 639
            .:...|...::.|. .:..:|:|.|..:|          |.:||.||.|..|:    |:..|. .
Mouse   289 RIGKVLDNAIETEK-MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ----LQAFNT-Y 347

  Fly   640 STLPLPPHRP--------LSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSR 696
            .|:..||...        |.||:.|.|..::..|.....:||            ||.|.:     
Mouse   348 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLI------------SDINKA----- 395

  Fly   697 CASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDS 761
                               |                 :::..:.|:|.     .:||.:      
Mouse   396 -------------------W-----------------ERLEKAEHERE-----LALRNE------ 413

  Fly   762 GYKSARADSLEQRA-EFIRQDSLRSEYLSDRESRYGIVQQ-------ASIESTDSRMCYLTSSEI 818
               ..|.:.|||.| .|.|:.::|..:||:.:.   :|.|       .::|:...:...:.:...
Mouse   414 ---LIRQEKLEQLARRFDRKAAMRETWLSENQR---LVSQDNFGFDLPAVEAATKKHEAIETDIA 472

  Fly   819 SDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLL------RK 877
            :.::|:....||:.|.:.|:     |......||          ||...:.:.::||      |:
Mouse   473 AYEERVQAVVAVARELEAEN-----YHDIKRITA----------RKDNVIRLWEYLLELLRARRQ 522

  Fly   878 KHQIELARKR---------GW----------KGYWVCLKGTTLLF---------YPCDSREGRSV 914
            :.::.|..::         .|          :.|...|.|...|.         ....:...|.|
Mouse   523 RLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGV 587

  Fly   915 EAAPKHLIIVDGAIMQPIPEHPKRDYI----FCLSTAFGDAYLFQAPCQV--------------- 960
            .|:.:. ...||...:|......||.:    ||          :|..||:               
Mouse   588 NASAQK-FATDGEGYKPCDPQVIRDRVAHMEFC----------YQELCQLAAERRARLEESRRLW 641

  Fly   961 -------ELENWVNSIHSACAAAFARHRGK--TGTLHLL-QEEIFRLEKAIESDHKLKHMAELQQ 1015
                   |.|.|:.......:   :...||  |..:.|| :...|..|.:..|.|..:.:.|.:.
Mouse   642 KFFWEMAEEEGWIREKEKILS---SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 703

  Fly  1016 SVVTDQETRHQIQTQIL----QWEENLERLHC------------EQFR-----LRCYMASL---- 1055
            .:..:.....:|:.:|:    || .|||:|..            .||:     :..:|..:    
Mouse   704 MIAEEHFGSEKIRERIIYIREQW-ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIV 767

  Fly  1056 QSGELPNP-----------KSLLTHVS--RPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAG 1107
            .|.::.:.           |.:...::  |||.:||:: ....:...|    |.||.:...|   
Mouse   768 SSNDVGHDEYSTQSLVKKHKDVAEEITNYRPTIDTLHE-QASALPQAH----AESPDVKGRL--- 824

  Fly  1108 RGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASAC-- 1170
                           :|...|..:|   .|..:..|.|:.|    |:.|....|.    |.||  
Mouse   825 ---------------AGIEERCKEM---AELTRLRKQALQD----TLALYKMFSE----ADACEL 863

  Fly  1171 ----ARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHE-----FVEVCMKILY---- 1222
                ..:.||.|:   ..:|..|:|    .:.||.:.:|..::|..     ..::..::::    
Mouse   864 WIDEKEQWLNNMQ---IPEKLEDLE----VIQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHP 921

  Fly  1223 ---QVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAI 1284
               ::..|:..|...|  |...||::  .::|.|.        .::::.|..::.:|        
Mouse   922 SEKEIRAQQDKLNTRW--SQFRELVD--RKKDALL--------SALSIQNYHLECNE-------- 966

  Fly  1285 VSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMIT 1349
                    .:|.::|:   :.::.|::....||.|:|.:                     :..:|
Mouse   967 --------TKSWIREK---TKVIESTQDLGNDLAGVMAL---------------------QRKLT 999

  Fly  1350 GLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFE 1414
            |:          .:||.:.||:.|                            .:.|...:..|..
Mouse  1000 GM----------ERDLVAIEAKLS----------------------------DLQKEAEKLESEH 1026

  Fly  1415 IENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVD-------------- 1465
            .:.    |:....:.:....|...:.||.......|.:|.||::.:.:|.|              
Mouse  1027 PDQ----AQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIAS 1087

  Fly  1466 ---------TERTYVKHLN--NLLEHYLEPMKRETFLSNAEINALFGNIHEIVT---------FQ 1510
                     .|:...:|.|  |.:::|.|..::            ..::.|:||         |.
Mouse  1088 EDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK------------MRDMGEMVTQGQTDAQYMFL 1140

  Fly  1511 RQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNE 1575
            ||.||.|:..      :|:.....:.|..|.:...|:..::...|...:|.   :..:.||...|
Mouse  1141 RQRLQALDTG------WNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL---NNQEYVLAHTE 1196

  Fly  1576 GNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHV---------- 1630
            ....|:...||...::...:|:::...| |..:::....|....|:...|..|.|          
Mouse  1197 MPTTLEGAEAAIKKQEDFMTTMDANEEK-INAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN 1260

  Fly  1631 ---------------HLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPG 1680
                           .|.:.|:..::::..|||.....::..  :|.....|.|..|....::  
Mouse  1261 REAASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMS--YDEARNLHSKWLKHQAFMA-- 1321

  Fly  1681 DLLYYGGVEWLNISDFLGKI-KKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVE 1744
                    |..:..::|.|| |:|::|.:.    |.....:.||:|....|:..|.......:. 
Mouse  1322 --------ELASNKEWLDKIEKEGMQLISE----KPETEAVVKEKLTGLHKMWEVLESTTQTKA- 1373

  Fly  1745 IIRYQVLIPVTEVQVRASSAKDMDSHFLWELIH-LRSQLQRRSEKVYVLSNSTADFRNAFLKTIR 1808
                |.|....:.::...|..|:|.   |  :| |.||:|             :|.....|.::.
Mouse  1374 ----QRLFDANKAELFTQSCADLDK---W--LHGLESQIQ-------------SDDYGKDLTSVN 1416

  Fly  1809 QIIRES---VRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGK 1870
            .::::.   ...|.:..|............|.:|         ..|.|...:::|:......|.:
Mouse  1417 ILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG---------KSTDEVDSKRLTVQTKFMELLE 1472

  Fly  1871 PKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTE 1935
            |..:   ::|        ||..|:|          :|..:.....:.:          .||:...
Mouse  1473 PLSE---RKH--------NLLASKE----------IHQFNRDVEDEIL----------WVGERMP 1506

  Fly  1936 ITCSSPEPHQQQQQQ----QQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERI 1996
            :..|:...|..|..|    :.|..|...|||                    ||.:.......:.|
Mouse  1507 LATSTDHGHNLQTVQLLIKKNQTLQKEIQGH--------------------QPRIDDIFERSQNI 1551

  Fly  1997 DPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASY------ 2055
            ...:.|...|..:|.....|...|             |.:..|..:.|.::.:|....|      
Mouse  1552 ITDSSSLNAEAIRQRLADLKQLWG-------------LLIEETEKRHRRLEEAHKAQQYYFDAAE 1603

  Fly  2056 -------QPVLMKDLGKPSPDESE---------LESESEVHAAQVAASFNLSLGSSGSLFASDAR 2104
                   |.:.|....|...::|.         ||...|.:|..|   ..|| .:|.:|.|....
Mouse  1604 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETV---HQLS-KTSRALVADSHP 1664

  Fly  2105 DNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPK--------QDIEVIEIFESEAERLAASQQVAVV 2161
            :::..|..||::..|:...:....:...:..:        ::::.:|.:.:|.|.:|.|.::...
Mouse  1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729

  Fly  2162 HQHPS-------DQARESGH--KQRRDRDRNPTE-------TDAT-------------------- 2190
            ::|.:       :.||::|:  ::|.|...|..:       :||.                    
Mouse  1730 YEHVTMLQERFREFARDTGNIGQERVDTVNNMADELINSGHSDAATIAEWKDGLNEAWADLLELI 1794

  Fly  2191 ------------------------ARFMDKHL---SDLEQENLTDGTC---------DIVAYMES 2219
                                    .|..|||.   .:|.::..|..|.         ||.|....
Mouse  1795 DTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ 1859

  Fly  2220 LR---------------EKAFDPQ--------------DLAE-------DTGDH----------- 2237
            :|               :||.|.|              |..|       ||||.           
Mouse  1860 VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACEGRRVRLVDTGDKFRFFSMVRDLM 1924

  Fly  2238 -------QQNDSSLSPEPQTIVE---NTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEE 2292
                   :|.::...|...:.||   |..|.:..:|::.:...|.....|.:....:....|..:
Mouse  1925 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKSLLARKHYASEEIK 1989

  Fly  2293 EATTSSLASHIVVIDKKVDK------IFKAKSPERPASTK---VKGGRRQIYISPDRCKSQGSSP 2348
            |...........:|||..|:      |.:.....|.||..   :.|  ::.|:|   .:..|.|.
Mouse  1990 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLG--QEPYLS---SREIGQSV 2049

  Fly  2349 VRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGILKP 2413
            ..:.|:.....:..   |..:....|.::.:||:. ......||..|.....:....|||.  ..
Mouse  2050 DEVEKLIKRHEAFE---KSAATWDERFSALERLTT-LELLEVRRQQEEEERKRRPPSPDPN--TK 2108

  Fly  2414 PSSPAKSKSPDRS----CLKKGGPSHVCSVETLSPRVSPRGSMDHLSPDRG----MTSSSCLRHS 2470
            .|..|:|:..|.|    ..:.|.|:     |..|||::  |:|:......|    .|||......
Mouse  2109 VSEEAESQQWDTSKGDQVSQNGLPA-----EQGSPRMA--GTMETSEMVNGAAEQRTSSKESSPV 2166

  Fly  2471 PRSSFDSHGES-----------DHNLDVPHG------SRKRSMSAHGSFETGTRPRAQETYQYYP 2518
            |..:.|...:|           ...|:.|..      :||....||..     :..::..:..|.
Mouse  2167 PSPTLDRKAKSALPAQSAATLPARTLETPAAQMEGFLNRKHEWEAHNK-----KASSRSWHNVYC 2226

  Fly  2519 VYDNQ 2523
            |.:||
Mouse  2227 VINNQ 2231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 29/186 (16%)
PH 873..974 CDD:278594 25/160 (16%)
TIAM1_RBD 1141..1219 CDD:176413 19/88 (22%)
PDZ_signaling 1221..1308 CDD:238492 12/93 (13%)
RhoGEF 1456..1647 CDD:238091 40/249 (16%)
PH2_Tiam1_2 1650..1823 CDD:269957 31/177 (18%)
PH 1693..1812 CDD:278594 25/120 (21%)
Sptbn1NP_787030.2 Actin-binding 2..275 40/233 (17%)
SAC6 48..>530 CDD:227401 105/591 (18%)
Spectrin 1. /evidence=ECO:0000255 303..411 30/170 (18%)
Spectrin 2. /evidence=ECO:0000255 423..525 22/119 (18%)
SPEC 530..743 CDD:238103 39/227 (17%)
Spectrin 3. /evidence=ECO:0000255 530..636 18/116 (16%)
Spectrin 4. /evidence=ECO:0000255 639..742 21/106 (20%)
SPEC 642..849 CDD:238103 43/240 (18%)
Spectrin 5. /evidence=ECO:0000255 745..847 21/127 (17%)
Spectrin 6. /evidence=ECO:0000255 850..952 22/116 (19%)
SPEC 851..1061 CDD:238103 46/314 (15%)
Spectrin 7. /evidence=ECO:0000255 957..1060 23/184 (13%)
SPEC 958..1169 CDD:238103 46/310 (15%)
Spectrin 8. /evidence=ECO:0000255 1063..1166 22/120 (18%)
Spectrin 9. /evidence=ECO:0000255 1170..1259 17/92 (18%)
SPEC 1171..1380 CDD:238103 40/233 (17%)
Spectrin 10. /evidence=ECO:0000255 1276..1376 23/120 (19%)
SPEC 1381..1592 CDD:238103 48/301 (16%)
Spectrin 11. /evidence=ECO:0000255 1381..1482 22/138 (16%)
Spectrin 12. /evidence=ECO:0000255 1486..1590 24/156 (15%)
Interaction with ANK2. /evidence=ECO:0000250 1563..2093 92/555 (17%)
SPEC 1593..1805 CDD:238103 33/215 (15%)
SPEC 1806..2027 CDD:238103 38/220 (17%)
Spectrin 2017..>2075 CDD:334073 11/65 (17%)
Spectrin 17. /evidence=ECO:0000255 2018..2097 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2193 25/112 (22%)
Mediates interaction with CAMSAP1. /evidence=ECO:0000250 2148..2176 6/27 (22%)
PH_beta_spectrin 2199..2304 CDD:269975 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2308..2363
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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