DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Arhgef17

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001074585.1 Gene:Arhgef17 / 207212 MGIID:2673002 Length:2057 Species:Mus musculus


Alignment Length:2395 Identity:440/2395 - (18%)
Similarity:732/2395 - (30%) Gaps:879/2395 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 GSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRS------------- 554
            |.|.|.....|::...:|       |....|:   :...:.|:|...||.|:             
Mouse   134 GGPSSRRPSMDSEALGST-------SPDRVSW---EPPTRDPRQPPTPPPRTCFPLAGLRSARPL 188

  Fly   555 -------SRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSM 612
                   .|.:.|.||.....|..|           :|              |.|:|    ||..
Mouse   189 SGPGIEGRRRRQHQQQERAQRPADG-----------LH--------------SWHSF----SQPQ 224

  Fly   613 ENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERE 677
            ..   |.:...|:..|.||:.|..|.||:                 :.:.:|..|...       
Mouse   225 AG---ARASSSSSIASSYPVSRSRAASSS-----------------EEEEEGPQSQLG------- 262

  Fly   678 RERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTI--------------GSGSG 728
             .:...||..|:|......    .||..| :|  ...|.|.|.|.:              |.||.
Mouse   263 -PQSPAYLGGHSSGSDEDP----NGEDGR-RW--RGRGLRPGRSQLVHGCSQDSDELNPGGLGSA 319

  Fly   729 HGMMTQQIPGSGH-KRSPWDS-----LP----SLRQDSSLNDSGYKSARADSLEQRAEFIRQDSL 783
            .|:.:.:.|.|.. ....|.:     ||    |||..|....:.::.|:...             
Mouse   320 GGVGSPEPPTSPRTSMDEWGTGTQPCLPGPQESLRPMSDTGGAPFRVAKVSF------------- 371

  Fly   784 RSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKA 848
             ..||:......|..:.:|.|:            :.|||..|..::|     |..|..||.....
Mouse   372 -PAYLASPAGSRGSSRYSSTET------------LKDDDLWSSRSSV-----GWGVYRSPSFGTG 418

  Fly   849 TG------TAASSFNCTGAVR--KAGFLSVKKWLLRKK---------------------HQIELA 884
            .|      |.:.|....|..|  :.|.|.:.|...||.                     .::.:.
Mouse   419 DGLLLRPQTRSRSKGPVGTARPLRDGGLDLDKNRQRKSLSNPDIASETLTLLSFLRSDLSELRVR 483

  Fly   885 RKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFG 949
            :..|..|.           .|.|.|:..|.           |:.|:.                 .
Mouse   484 KPSGGPGN-----------RPLDGRDSPSA-----------GSPMEQ-----------------S 509

  Fly   950 DAYLFQAP----CQVELENWVNSIHSA----CA-AAFARHRGKTGTLHLLQEEIFRLEKAIESD- 1004
            ::.|.|:|    .:..|::...::..|    |: ...||...:|..|.....|:.......|.| 
Mouse   510 ESTLSQSPTSPTTRPTLKDLTATLRRAKSFSCSEKPMARRLLRTSALKPSSSELLLAGSGAEEDP 574

  Fly  1005 ----------HKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGE 1059
                      .:.:.:.|..|.:...|:..:.:......|..::.:.|..|            .|
Mouse   575 LPLVVQDQYVQEARQVFEKIQRMGAQQDDGNDVCPTSPDWAGDMTQGHRSQ------------EE 627

  Fly  1060 LPNPKSLLTH---------------------VSRPTKNTL----NKLGVFTVSSF--HAFICARS 1097
            |..|:|.||.                     |.||..:|.    :.||..|..|.  .|.:...:
Mouse   628 LSGPESNLTDEGIGADPEPLGAAFCSLDPAGVWRPLSSTSAQTNHHLGAGTEDSLGGRALVSPET 692

  Fly  1098 PSLLNNLLAGRGATKRR---PPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDA 1159
            |..       .||.:||   ||      ||.:...:......|            ||        
Mouse   693 PPT-------PGALRRRRKVPP------SGPNGTELSNGEASE------------AY-------- 724

  Fly  1160 MSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQV 1224
                                        |.:.|.   :|.|:                       
Mouse   725 ----------------------------RSLSDP---IPQRH----------------------- 735

  Fly  1225 ELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLD 1289
              :..|.|:..||||::.|:.:...:..|        ..:.||..|:..|..    :.::||:.:
Mouse   736 --RAATSEEPSGFSVDSNLLGSLNSKTGL--------PVTPAMDEGLTSGHS----DWSVVSEEN 786

  Fly  1290 MMY---LESVLQ------------------EEQSLSMMMRSSRTEPPDLVG----IMRVTDDMID 1329
            ..|   ::|::|                  :::|||...|......|...|    .:|..:.|: 
Mouse   787 KDYQEVIQSIVQGPGALGRMGEDRIAGKTPKKKSLSDPSRRGELTGPGFEGPGGEPIREVEPML- 850

  Fly  1330 SLVCPPPPTDPPVMSEEMITGLIVPAP--GWNGTSKDLYSPEAESSPATSF-VDP---AAMAAQL 1388
                 ||.:..|:::|:. |....|||  |...:.:.|.:|.|.|:....| :||   :.::.:|
Mouse   851 -----PPSSSEPILAEQW-TEPEDPAPARGRAQSERSLPAPPASSTAHHDFHLDPKLTSVLSPRL 909

  Fly  1389 AVGG--------------------------------------------------------VGGVV 1397
            ...|                                                        ||..|
Mouse   910 TRRGSKKRPARSSHQELRREEGNQDQTGSLTQTRSSSKHVRHASVPATFTPIVVPEPAMSVGPPV 974

  Fly  1398 VGGLGVAKPTSRTSSFEIENLLKTAEQETRK-----------------------SSPTGSVTSSV 1439
            .....|..|.....:.:..:|    |..|::                       |:|..:.|...
Mouse   975 AAPEPVGFPVRGHPALQAPSL----EDVTKRYMLTLHSGDVPAPGPVDLPCLPPSAPPSTETKPS 1035

  Fly  1440 STTALTP----------SRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKR--ETFLS 1492
            .....||          |:...|..|  .|.|.|:|||::||:.|..|::.|::|:|:  .:.|.
Mouse  1036 GAARATPDEPAPASKCCSKPQVDMRK--HVTMTLLDTEQSYVESLRTLMQGYMQPLKQPENSLLC 1098

  Fly  1493 NAE-INALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF-- 1554
            :.. ::.:|..|.|::....|||:.:             .||.|..:....:|:..   |..|  
Mouse  1099 DPSLVDEIFDQIPELLEHHEQFLEQV-------------RHCVQTWHAQQKVGALL---VQSFSK 1147

  Fly  1555 ----KLYSSFCASHSKAQKVLH-PNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLL 1614
                .:||::..:...|:..:. ..|...|..:||.....:.:....|...:|||:|||.:|.||
Mouse  1148 DVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELL 1212

  Fly  1615 LQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSP 1679
            ::.:...|.....:|..|.:|.:.:::|||.||:..|..||         .:......|.|:   
Mouse  1213 VKDLLKHTPEDHPDHPLLLDAQRNIKQVAERINKGVRSAEE---------AERHARVLQEIE--- 1265

  Fly  1680 GDLLYYGGVEWLN--ISDFL------------GKIKKGLELHAMCFVFKSAVVFLCKERLRQKKK 1730
               .:..|:|.|.  :..||            ||..:.|      |:|...:|  | ..|::|..
Mouse  1266 ---AHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSL------FLFTDLIV--C-TTLKRKSG 1318

  Fly  1731 LMGVSSKNATNEVEII----RYQVL--IPV--TEVQVRASSAKDMDSHFLWELIHLRSQLQRRSE 1787
            .:..||.:......:|    :|::|  :|:  |::...||.|.:.::        ::..:.|..|
Mouse  1319 SLRRSSMSLYTAASVIDTASKYKMLWKLPLEDTDIIKGASQATNRET--------IQKAISRLDE 1375

  Fly  1788 KVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMG-------SMGY 1845
            .               |.|:.|:.:.| .::..|.::...:...:|....:.:.       |:.:
Mouse  1376 D---------------LATLGQMSKLS-ESLGFPHQSLDDALRDLSAAMHRDLSEKQALCCSLAF 1424

  Fly  1846 PGNSQTL--ERPKQQITIV----HGSHTLG------KPKKKSGSQRHSAGNIDYDNL-------- 1890
            |.....|  .||:...:.:    |....||      :.|:|..|   |...:|.:.|        
Mouse  1425 PPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLAS---SKSCLDPEFLKAIPIMKT 1486

  Fly  1891 -SGSQEADDLPPSVGVVHYASGHTHGQQMQPA---------GFRG-------RSKTVGDVTEITC 1938
             ||.|.:...|            |.....:||         |:.|       |::...:.....|
Mouse  1487 RSGMQFSCAAP------------TFSSCPEPAPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVC 1539

  Fly  1939 SSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPH-PREPPPPPIRQPHLHHHSSDIERIDPGTKS 2002
            |:               :::..|   |.|...|. ||| .|.|:|.|                  
Mouse  1540 SA---------------RILCIG---AVPGLQPRCPRE-QPEPLRNP------------------ 1567

  Fly  2003 EGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGST----GSQARL-IQSSHPPASYQPVLMKD 2062
                        |:.||..|...|.:..|:.....:|    |.|..| |..|......:|...| 
Mouse  1568 ------------PETTLESTGPELDVEATAEEEAATTLAEPGPQPCLHISISGSGLEMEPGPAK- 1619

  Fly  2063 LGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSP 2127
             |.|.|:....:|:|:..::. :.|..|...:|.|..:|...:.:|.|..::...:......|.|
Mouse  1620 -GDPQPELVPFDSDSDDESSP-SPSGTLQSQASQSTISSSFGNEETPSSKEATAETTSSEEEQEP 1682

  Fly  2128 -------------------------RQSPRQS-PKQDIEVIEIFESEAERLAA--SQQVAVVHQH 2164
                                     |:|.|.| .:..:|.:...:.||.:.:.  ..:...||.:
Mouse  1683 GFLSLSGSFGPGGPCGTSPMDGRALRRSSRGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY 1747

  Fly  2165 PSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLRE--KAFDP 2227
            .|..:       .|||..:.....|.:.....:|::....:|.:|  ::|.|.   ||  :.:||
Mouse  1748 QSSDS-------IRDRRNSMKLQHAASVTCILYLNNKVFVSLANG--ELVVYQ---REAGRFWDP 1800

  Fly  2228 QDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNT--TGPSER----S 2286
            |:....|                            :.|...|.|:..|.|..  .|...|    |
Mouse  1801 QNFKSMT----------------------------LGSQGSPITKMVSVGGRLWCGCQNRVLVLS 1837

  Fly  2287 GDETEEEAT----TSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISPDRCKSQGSS 2347
            .|..:.|.|    ..|..|...::|..:.           ....:||........||..:.....
Mouse  1838 PDTLQLEHTFYVGQDSSRSVACMVDSSLG-----------VWVTLKGSAHVCLYHPDTFEQLAEV 1891

  Fly  2348 PVR--IIKIKSPRTSLSDQGK-------RLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHT 2403
            .|.  :.::.:...::..|.|       .|.||:      :.|..|         :..|.:|...
Mouse  1892 DVTPPVHRMLAGSDAIIRQHKAACLRITALLVCA------ELLWVG---------TSAGVVLTIP 1941

  Fly  2404 TGPDPGILKPPSSPAKSKSPDRSCLKKGGPSHV---------------CSVETLSPRVSPR--GS 2451
            |.|     ...|.|....||...|  :|...||               ||.....|...|.  .|
Mouse  1942 TSP-----STVSCPRAPLSPAGLC--QGHTGHVRFLAAVQLPEGFNLLCSTPPPPPDTGPEKLPS 1999

  Fly  2452 MDHL-SP-DRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSRKRSMSAHGSFET 2504
            :||. || .||.||:     .|:....|.|:...:.       :.|....||.||
Mouse  2000 LDHRDSPRRRGPTSA-----RPKMLVISGGDGSEDF-------RLSSGGGGSSET 2042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 23/156 (15%)
PH 873..974 CDD:278594 15/129 (12%)
TIAM1_RBD 1141..1219 CDD:176413 6/77 (8%)
PDZ_signaling 1221..1308 CDD:238492 20/107 (19%)
RhoGEF 1456..1647 CDD:238091 50/200 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/194 (19%)
PH 1693..1812 CDD:278594 26/138 (19%)
Arhgef17NP_001074585.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..361 60/300 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..461 23/102 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..559 18/116 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..647 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 663..952 65/396 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1054 5/38 (13%)
RhoGEF 1067..1246 CDD:279015 49/194 (25%)
PH-like 1279..>1425 CDD:302622 30/178 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1713 37/191 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1983..2050 21/72 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.