Protein Alignment sif and prhg-1

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_001122556.1
• Gene: prhg-1 / 190810
• WormBaseID: WBGene00022391
• Length: 628
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 119/524 - (22%)
• Similarity: 192/524 - (36%)
• Gaps: 159/524 - (30%)

  Fly  1414 EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYV-KHLNNL 1477
            |:|.||..:.:|......|.::.||              ..|..:.|.||..||..:: :.|..|
 Worm   165 ELEKLLPVSFEEMFMGDETTTIPSS--------------KHKYLQAVWELFHTELVFLYRQLFVL 215

  Fly  1478 LEHYLEPMKR---ETFLSNAEINALFGNIHEIVTFQRQFLQ---NLEESLDLEPDFNKFEHCGQF 1536
            .:.|.||:||   |..|...|.:.||||:.::....|.|.|   :|..::|.|.     ..|.|.
 Worm   216 RDVYKEPLKRCQVEGCLLLVEPDLLFGNLDQLCRISRTFCQSFLSLLSTVDKEN-----WDCTQL 275

  Fly  1537 RNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSS------ 1595
            ...||   ..|....:....|.::|.::.             |..|:|.:...|::..:
 Worm   276 VVDLF---ERFSKGPSTISAYQAYCINYK-------------ATMEYLGSIRQKEERFTEFERIC 324

  Fly  1596 ---------TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKG-MEKVAEHINEMQ 1650
                     .||..||.|:|||.:.|:||:::..    |::|     |..|| :|||.:.:.|..
 Worm   325 LADERCFRLQLEDLLIAPLQRITRLPILLREIHK----RSEE-----EESKGKVEKVIDTMTESL 380

  Fly  1651 RIHEEYGAIFD-----HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDF-------------- 1696
            |      :|.|     |.|.:.|:...|              |.|.||||.
 Worm   381 R------SIDDSVQWLHNFERLQQLQTQ--------------VVWPNISDLEPKSYVPDFLRVAL 425

  Fly  1697 ---------------------LGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNAT 1740
                                 |..::.|..:....|:|....|....::...|.|:.||..  ..
 Worm   426 SRQFCENLLAHPRRKLIHEGPLELVENGRTVDMYAFLFNDMFVLTKTKKCASKLKVKGVPI--GK 488

  Fly  1741 NEVEIIRYQVLIPVTEVQVRASSAKD----MDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRN 1801
            :|..|::.|. :|:.......:.:.|    |...|.:.:||    |.|..:.|.:.:...||
 Worm   489 SEHYIVQRQP-VPLDSCVFCDADSNDQATPMSLKFAFVIIH----LTRYYQVVGIYTLQAAD--- 545

  Fly  1802 AFLKTIRQI----IRESVRNM-SIPMKN-------FGGSSGSVSGHSSQGMGSMGYPGNSQTLER 1854
               |..:::    .:||:.|. ||.:|:       |  ||.|:...||..:.|.. ..||..|.:
 Worm   546 ---KADKELWIEKFQESIENYESIQLKDMLKCTPLF--SSLSLRRCSSSRLMSKS-ESNSPQLPK 604

  Fly  1855 PKQQ 1858
            .|::
 Worm   605 EKEK 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	55/213 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	42/221 (19%)
		PH	1693..1812	CDD:278594	27/161 (17%)
prhg-1	NP_001122556.1	RhoGEF	196..385	CDD:279015	58/224 (26%)
		PH_PLEKHG7	440..557	CDD:270065	24/129 (19%)
		PH	441..561	CDD:278594	26/132 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910