DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and vav-1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001359918.1 Gene:vav-1 / 181153 WormBaseID:WBGene00006887 Length:1007 Species:Caenorhabditis elegans


Alignment Length:909 Identity:180/909 - (19%)
Similarity:307/909 - (33%) Gaps:267/909 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1407 TSRTSSFE------------IENL---------LKTAEQETRKSSPTGSVTSSVSTTALTPSRQL 1450
            ||..|.||            |||:         :.:|:.|.::|.   .:...:.|.. .||...
 Worm   170 TSNGSEFEDDVEIYQSLHDNIENVDPNRTIYGPITSADPEEQQSE---QLYDRIVTNR-KPSMNE 230

  Fly  1451 TDAE-----KLRKVVMELVDTERTYV-KHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTF 1509
            .|.:     |..:.:.||.|||:.|| :.|..:::.:.||:|  ..:..::.|.:||||.||...
 Worm   231 NDLQNTPTLKRNRCIRELYDTEKNYVAQALVTIIKTFYEPLK--GIIPTSDYNIIFGNIEEINVL 293

  Fly  1510 QRQFLQNLEESLDL--------EPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCA---- 1562
            ....|.:||..:.:        .|.......|     |...||..|:.|.:.|..|..:|:    
 Worm   294 HTALLADLEYPVKVALGLSDATPPRPISLNEC-----VPQTIGEVFIKYRDQFLAYGKYCSNLPD 353

  Fly  1563 SHSKAQKVLHPNEG-NHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRA 1626
            |...:.::|..||. :..:.|..|..|.|    ..:...|..|.||:.||||||::::..||..:
 Worm   354 SRKLSNELLKTNEFISRNINELTAQGNCK----FGMNDLLCVPFQRLTKYPLLLKELQKKTDLAS 414

  Fly  1627 DEHVHLCEALKGMEKVAEHINEMQRIHEEYGAI--FDHLFRQHQKSCKQPIDLSPGDLLYYGGVE 1689
            .:...|.||::.||.|..:|||..|   :..||  .|.: .|.......|:::...|   ||.| 
 Worm   415 PDRKSLEEAVEVMEDVCNYINEESR---DTNAIKVIDEI-EQSITDLSMPLNVKLHD---YGRV- 471

  Fly  1690 WLNISDFLGKIK--------KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEII 1746
              |:.   |::|        .|.......|:|...:| :||    ...|:|...:..|:......
 Worm   472 --NLD---GEVKMAESTLTQAGKPKQRYIFLFDKVIV-VCK----AANKVMAAKTTGASARTNTF 526

  Fly  1747 RYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQII 1811
            .|:....::|:.:..:::.|:.|         ...:.||::.|.:::....: .|...:......
 Worm   527 TYKNAYVMSELTIDKNASLDVKS---------GGTITRRTQYVIIMTRDRNE-NNEITQLTFYFK 581

  Fly  1812 RESVRNMSI-----------PMKNFGGSSGSVSGHS-----------------SQGMGSMGYPGN 1848
            .|:.||..:           |......::..|:.||                 .:|:...||...
 Worm   582 NEATRNNWMTALLLSKSNVSPTDYLRDTNHKVAFHSFRVDVKNPATCDVCDKLMKGLQYQGYKCE 646

  Fly  1849 SQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHT 1913
            |..:...|:.:.:           ||..:.|.|                               |
 Worm   647 SCNMSMHKECLGL-----------KKCEAVRKS-------------------------------T 669

  Fly  1914 HGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGH---AHAHPHPHPHPRE 1975
            |..:...:              ..|:.|..|             :.:|.   |:::..|      
 Worm   670 HETRSSQS--------------FNCNRPRFH-------------IHEGDIVVANSNSTP------ 701

  Fly  1976 PPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTG 2040
                           ||:..:........|....||..|....|....|...|.....:|...|.
 Worm   702 ---------------SDLSYLQFAKGDRIEVIKMQGHNRFTGCLINNRNRTGLVHLDHVSQSRTT 751

  Fly  2041 SQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSL---FASD 2102
            |...|.....|..|..|.::::.....|::.                  ||.|||.||   ..|.
 Worm   752 SMIGLSPIDSPAGSIAPRVVRNESTVLPNKL------------------LSDGSSRSLSGPHGSR 798

  Fly  2103 ARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEI--FESEAERLAASQQVAVVHQHP 2165
            :..|.:.|.....:.|:           |||....:.|:.|.  :..|.||..|...:       
 Worm   799 SSRNSSSSTINGSMDSV-----------PRQQDYVNTEISEFLWYMGEMERAKAESTL------- 845

  Fly  2166 SDQARESG-HKQRRDRDRNPTETDATARFMDKHL-----SD----LEQENLTDGTCDIVAYMES 2219
              :...:| ...|..::|..|....:.:...||:     ||    |:::.:.:.|.::|.|..|
 Worm   846 --KGTPNGTFLVRYSKNRKQTAISLSYKNDVKHMIIEQNSDGKVYLDEDYIFNSTVELVQYYRS 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 57/204 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 34/193 (18%)
PH 1693..1812 CDD:278594 19/126 (15%)
vav-1NP_001359918.1 CH 38..149 CDD:237981
RhoGEF 241..435 CDD:238091 57/204 (28%)
PH_Vav 453..602 CDD:269930 28/172 (16%)
C1 616..657 CDD:237996 7/40 (18%)
SH3 693..746 CDD:388381 11/73 (15%)
SH2_Vav_family 825..925 CDD:198193 19/92 (21%)
SH3 927..987 CDD:214620
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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