DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and sma-1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_741632.2 Gene:sma-1 / 179629 WormBaseID:WBGene00004855 Length:4166 Species:Caenorhabditis elegans


Alignment Length:2592 Identity:446/2592 - (17%)
Similarity:758/2592 - (29%) Gaps:990/2592 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   553 RSSRH-----QHH-------HQQAPNVTPT-----------PGSPTSRL-----LLEYEM-HLRN 588
            |..:|     |||       |...|.:...           ||....::     .||.|. .|:|
 Worm  2010 RDVKHVHSLWQHHEALDKEIHNSQPRLAKLVEEAERLKKTYPGGNAEQIGGRQQTLEQEWEELKN 2074

  Fly   589 TL--AKGMDAESYSLHTFEA----LLS---------QS---MENLEFAESLPGSNQRSPYPLRRP 635
            ..  .|.|...::.||||..    ||:         ||   :.:|:.||.|...:.|..:.:...
 Worm  2075 ATDDRKDMLRAAFDLHTFNGKVRDLLAWTDLTISDIQSDLHINDLQQAEWLQTEHSRLSHEMDAR 2139

  Fly   636 NAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSD----RNELIRER-ERERD-----RGYLSDHNS 690
            ..:.:.|          :.|.|:......|.|:    :..|::.. ||.|.     .|:||.   
 Worm  2140 EPEFARL----------VNDGEKMITAQHYASEEIKNKTHLLKSALERLRSEWALRNGFLSQ--- 2191

  Fly   691 SFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMM---TQQIPGSGHKRSPWDSLPSL 752
                           ..||                   |...   .|.|...|.||:   :|.||
 Worm  2192 ---------------AVQW-------------------HAFQREAKQIIASIGSKRT---TLRSL 2219

  Fly   753 RQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSE 817
            ....|:.|...::.|.|:.|:                            ::.:.|.|        
 Worm  2220 AVGGSVADVESQTKRLDTFEK----------------------------ALSTLDER-------- 2248

  Fly   818 ISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIE 882
                      ||..|....|.:.|...::|                     ::..|......:::
 Worm  2249 ----------TATLDHTANELMKARHMESK---------------------NISMWQSNVHEELK 2282

  Fly   883 LARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTA 947
            |.|                          :.:||  :|.::.|.               |.|::.
 Worm  2283 LLR--------------------------QDIEA--RHAMLKDA---------------FALASF 2304

  Fly   948 FGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAE 1012
            ..|.        .::|.|::.              ||..:...|:   ...::|..|.|:|.: :
 Worm  2305 DSDV--------AQIEAWIDE--------------KTNGVRKAQD---LSSESISIDEKMKRL-Q 2343

  Fly  1013 LQQSVVTDQETRHQIQTQILQWEENLERLH--------CEQFRLR-------CYMASLQSGELP- 1061
            ..|::..:......:..||||....|:.||        |::...:       |...||...|.. 
 Worm  2344 THQALEAEVTANKPVVDQILQRGNQLKNLHRNPKIANRCDELSYKWNQLSGACADQSLALEEARD 2408

  Fly  1062 ---------------NPKSLLTH--------------------------VSRPTKNTLNKLGVFT 1085
                           |.|.:|..                          |...|.:.:|:||...
 Worm  2409 LLRFKQLVENVLAWINEKEVLVSTADMGKDMEHCRLLLERLDGTRSDSIVDEQTLDEINRLGEKL 2473

  Fly  1086 VSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNA 1150
            |..                  ||                |||..:|...:...|| :::.:...|
 Worm  2474 VKQ------------------GR----------------SSRDQVQKEQQHLNEK-WRLLLGQLA 2503

  Fly  1151 YSTVYLRDAMSVEEF-----------------LASACARRNLNPMEHFVRVKK--RRDMED-HNY 1195
            :....|..||.|..|                 :.|....::...:|..||.:.  .|||.. |..
 Worm  2504 HYRTELLAAMEVHTFNRDVEDTDERIHEKVAAMKSDDYGKDFASVELLVRKQSALERDMSAIHQK 2568

  Fly  1196 FVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTT-------LEQMW-GFSVEAEL-IENAERQD 1251
            .:.|..|              ..|||.:....|.|       ||:.| ..|..||| .|...|..
 Worm  2569 LIAHDKD--------------AQKILEKRPPLRETVLDSLKKLEESWEQLSKAAELRNEKLNRSF 2619

  Fly  1252 ELCCY---VSRVEDKSVAMHNGIIKGDEIMVINGA--IV-------SDLDMMYLESVLQEEQSLS 1304
            :|..|   |.:||..:..:.|.:.........|||  |:       :::|....|..|..|:..:
 Worm  2620 KLYKYLDDVKKVEQWANQVRNKMTSHQTPKDSNGARKILEQHHERKAEIDGRSEELRLLHEEGQA 2684

  Fly  1305 MMMRSSRTEPPDLVGIMRVTDDMIDS----------------------LVCPPPPTDPPVMSEEM 1347
            :    ::.:|.....:.|....:.:|                      |.|     |..|..|:.
 Worm  2685 L----NQEQPEHKAEVQRAHKRVQNSEHQLRQTWESEKGTLQKLLEWMLWC-----DEAVQCEQW 2740

  Fly  1348 ITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSS 1412
            :            :.|:......|....|..|:               :::.|....:.|.|..|
 Worm  2741 L------------SDKETQVARGELGDTTDAVE---------------MLIKGHSAFEETVRKQS 2778

  Fly  1413 FEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVME-----LVDTER--TY 1470
            .:|:.|.|.|:...       |..::.....:|.|.::|....|....||     |.|:::  .:
 Worm  2779 EKIDALTKNADALV-------SGGNNYRADIVTRSEEVTARHALLLKSMEKRGHMLEDSKKYHEF 2836

  Fly  1471 VKHLNNL---LEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEH 1532
            ::....|   :...|:....|:||.:..:.:   .:.:.:.|..:.::|       |...:..|.
 Worm  2837 IRQCGELIIWITAKLQLAYDESFLDHTNLRS---KLQKHMAFDSELVEN-------EKRLSTVER 2891

  Fly  1533 CGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTL 1597
            .|:           .|...||      |.:...||| ::....|...|:...|.:..:.:.:..|
 Worm  2892 QGE-----------QLVTDNH------FMSEQVKAQ-LVELRSGWDELRTKSALKTQRLREAFEL 2938

  Fly  1598 ESY--LIKPIQR-----------------ILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVA 1643
            .|.  .::.|::                 ||...||::::    ||...|.....:|      |.
 Worm  2939 HSLQRKVEDIEKWLDKVEGELSSDDHGRDILSTELLIKKL----DTLQTEIAGRSDA------VV 2993

  Fly  1644 EHINEMQRIHEEYGAIFDHLFRQHQK------SCKQPIDLSPGDLL----YYGGV-------EWL 1691
            |.:.:.:.:..:..|..|...:|.::      ...:|:.:...:|:    ::..|       |||
 Worm  2994 EMMKKARELRVQGSAAADDCLKQAEQVEARYSGLDEPVQIRRENLVDAQAFFQWVKAAEEDLEWL 3058

  Fly  1692 NISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTE 1756
              ||.:.....|                   |.....:..:.:..|:||.|.|:...|..:..||
 Worm  3059 --SDRMMLASSG-------------------ESGDSLQSALSLQKKHATLEKELDTRQSAMNDTE 3102

  Fly  1757 VQVRASSAKDM--DSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTI------------ 1807
                 ...|||  ..||  ...|::..|.|.|..:..|..|....|:...:.|            
 Worm  3103 -----QRGKDMIRQRHF--ASTHIQKILDRLSSAMLTLKESCGLRRDLLQEAIDAHEYYTEETEA 3160

  Fly  1808 RQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHG-----SHT 1867
            .|.:||   .|.:.|              ||.||.     :....|...:::|::..     .:.
 Worm  3161 EQWLRE---QMPLAM--------------SQEMGR-----DQAGAESHLRRLTVLDKEVELFKNE 3203

  Fly  1868 LGKPKKKS----GSQRHSAGNI-----DYDNLSGS----------------------QEADDLPP 1901
            :.:.||::    ..:.|.|.:|     ..:.|.|.                      ::||||..
 Worm  3204 IDRLKKRADGLLAREHHDAMSIAAKQRKLEALFGDLCRECARRRTQIVDASKYHKFVRQADDLSD 3268

  Fly  1902 SV-GVVHYASGHTHGQQMQPAGFRGRSKTV----GDVTEITCSSPEPHQQQQQQQQQQQQLMQQG 1961
            .: .....||...:||.::..     .:.:    ..|.|:..:.    ::....|:.|:.|::.|
 Worm  3269 WLREKERSASAEDYGQDLEDC-----QQIIEQFESTVRELAAAG----ERVAAVQRAQEDLLRSG 3324

  Fly  1962 HAH---------------AHPHPHPHPREPPPPPIRQPHLHHHSSD------IERIDPGTKSEGE 2005
            |.:               .|.:...:.|:......||.|.....:|      .::...|...|.|
 Worm  3325 HPYGASITAKGADVQRLWTHVNEVANERKQALNGARQVHRFDQEADQILNWLQDKEATGVAMEQE 3389

  Fly  2006 EDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDE 2070
            :.|:......||.|.|....:.........|.....:|..:.:|.|...:...:.:         
 Worm  3390 DLSRADLASVKAQLQRHDEFMHGMKAVEKQVAELCHEAERLWNSFPDTRHHLEVRR--------- 3445

  Fly  2071 SELESESEVHAAQVAASFNLS----LGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSP 2131
              |:.|.::.....||..:|.    :.|..|.|.......|.....||.:.|     .|.||...
 Worm  3446 --LDMEEQLKDILEAAKKHLEKLRHMQSLQSYFQEYREMMQWMKNMQSTMTS-----EQLPRDVA 3503

  Fly  2132 ------RQSPKQDIEV------IEIFESEAERLAASQQV----------------AVVHQHPSDQ 2168
                  |:..:.::|:      ::.|..:..|:..|..|                |::.:...|:
 Worm  3504 SCESLVRRHDEYNLEMQGRKPFVDDFARQGRRMIQSSHVLSQEIQEKVDILEKSWAMLCEIWKDR 3568

  Fly  2169 ARESGHKQRRDRDR---NPTETDA-----------------TARFMDKHLSDLEQENLT----DG 2209
            |..  :::..|..:   |..:.|:                 :....:.||.|.:...:|    ..
 Worm  3569 AEL--YEENMDVQKWKQNAEQLDSWLEERAGLLGDDWRMVDSVEMAETHLRDFDDFLVTLEAQSE 3631

  Fly  2210 TCDIVAYM-------ESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQ------TVVV 2261
            .||:|..:       ..||.|..|...:|||  |.::.|:....|...|:.|.:|      |..:
 Worm  3632 KCDMVKRLTLVEQNFSRLRSKEIDRARIAED--DQKRRDTIKIVEKGNILANRRQERERRKTQEI 3694

  Fly  2262 DIESPSRPATESDSTGNTTGPSERS----------------GDETEEEATTSSLASHIVVI---- 2306
            .:..|| |:.|..|| :|....||.                ||.....:|.:.|.|.:.:.    
 Worm  3695 SLLRPS-PSGEEFST-HTMPRKERKDRAKTTADLAPGAIQIGDILASSSTVAPLQSGVEMTKTPS 3757

  Fly  2307 --DKKVDKIFKAKSPERPASTKVK-----------GGRR-------------------------- 2332
              .::...|.|....|...:..:|           ||:|                          
 Worm  3758 FNTRRTQSIRKGSRWEDMGAIDMKGFFDRKQCQQSGGKRATIRSWKNYYGILCGQLLCFFKDEQQ 3822

  Fly  2333 ---------QIYISPDRCKSQGSSPVR---------------------------IIKIK------ 2355
                     .:||...:|:.......|                           :.|||      
 Worm  3823 FLENVAAAPPVYIYGAQCEQYPEYAKRKNSFRLLLQDGSEFIFSCPDERQMLEWVAKIKFHAHLT 3887

  Fly  2356 ------------------------SPRTSLS--DQGKRLSVCS-----SRDNSQDRLSAGRRTPS 2389
                                    :||.::.  |...|:|..|     |.|..|..|...||..|
 Worm  3888 PSNQLKSYAYNDDLFQSPDQPPMVAPRRNIGGHDVANRMSHASSVFTTSDDLEQHELDYSRRCSS 3952

  Fly  2390 PRRSSEGGGI-------LKHTTGPD-----PGILKPPSSPAKSKSPDRSCLKKGGPSHVCSVETL 2442
            ..|....|.|       |....|.|     |....|||.|..: :|  |.|.....|...:|   
 Worm  3953 LPRGKHSGQITMRDCATLPRGFGSDVMEQQPTAFFPPSGPLLA-TP--SVLTMSSSSMTANV--- 4011

  Fly  2443 SPRVSPR--------------------GSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDV 2487
            .|.|..|                    |.::....:....|:|      |.:.| |.|..|.:.|
 Worm  4012 MPTVVTRKIGVVRRASRRQSVYAESIYGEVEQAIAEANRVSTS------RPNGD-HAELRHTIQV 4069

  Fly  2488 PHGS---------RKRSMSAHGSFETGTRPRAQETYQYYP-VYDNQTCSDHYVAAAPTGRYGGGT 2542
            ..||         ::.:.|.:...|....||.|:..::.. |..||   .:.....|.|      
 Worm  4070 HPGSSGYTETLMYKEHTSSNYQPMERSVSPRNQQNGEFITWVESNQ---QNQPMNTPDG------ 4125

  Fly  2543 SSRSRLSKSLERSTSRDSTTTSSSYGHRAYGVSPDRNYVVFSSGPLRSQSAENTFSS 2599
                       ||||....:|.|:|.               .|..::|.|....|.|
 Worm  4126 -----------RSTSASVVSTPSNYD---------------DSDSIKSSSKRKGFGS 4156

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 13/124 (10%)
PH 873..974 CDD:278594 12/100 (12%)
TIAM1_RBD 1141..1219 CDD:176413 16/97 (16%)
PDZ_signaling 1221..1308 CDD:238492 26/107 (24%)
RhoGEF 1456..1647 CDD:238091 38/219 (17%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/203 (19%)
PH 1693..1812 CDD:278594 26/132 (20%)
sma-1NP_741632.2 CH 155..258 CDD:237981
CH 276..379 CDD:237981
SPEC 524..735 CDD:238103
SPEC 737..916 CDD:238103
SH3 928..979 CDD:214620
SPEC 1039..1237 CDD:238103
SPEC 1242..1450 CDD:238103
SPEC 1453..1553 CDD:197544
SPEC 1562..1762 CDD:238103
SPEC 1664..1874 CDD:238103
SPEC 1770..1980 CDD:238103
SCP-1 1967..2724 CDD:114219 161/952 (17%)
SPEC 1982..2192 CDD:238103 41/209 (20%)
SPEC 2194..2407 CDD:238103 56/370 (15%)
SPEC 2408..2618 CDD:238103 46/258 (18%)
SPEC 2620..2830 CDD:238103 42/252 (17%)
SPEC 2832..3041 CDD:238103 38/246 (15%)
SPEC 3044..3253 CDD:238103 47/258 (18%)
SPEC 3255..3466 CDD:238103 38/230 (17%)
SPEC 3361..3574 CDD:238103 39/230 (17%)
SPEC 3472..3689 CDD:238103 41/225 (18%)
PH_beta_spectrin 3780..3883 CDD:269975 11/102 (11%)
PH 3780..3881 CDD:278594 9/100 (9%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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